Reflux nephropathy and hypertension: COrrelation with the progression of renal damage
The aim of this study was to evaluate the relationship between blood pressure (BP), measured with ambulatory blood pressure monitoring (ABPM), and the progression of renal damage in 100 (70 females, 30 males) normotensive children with reflux nephropathy (RN). The patients, mean age of 13.5+/-5 year...
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| Veröffentlicht in: | Pediatric nephrology (Berlin, West) West), 2003-03, Vol.18 (3), p.241-245 |
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| creator | LAMA, Giuliana ADOLFO TEDESCO, Michele GRAZIANO, Luisa CALABRESE, Elvira GRASSIA, Carolina NATALE, Francesco PACILEO, Giuseppe RAMBALDI, Pier Francesco ESPOSITO-SALSANO, Maria |
| description | The aim of this study was to evaluate the relationship between blood pressure (BP), measured with ambulatory blood pressure monitoring (ABPM), and the progression of renal damage in 100 (70 females, 30 males) normotensive children with reflux nephropathy (RN). The patients, mean age of 13.5+/-5 years and almost 5 years of follow-up, were divided according to degree of RN into group A (I/II) and group B (III/IV). For each subject, 24-h systolic and diastolic BP (SBP-DBP), load (percentage of BP readings that exceeded the age- and sex-specific 95th percentile), and biochemical parameters were recorded. There was no significant difference in casual BP between the groups. The mean 24-h SBP-DBP and load were significantly higher in group B than A. There was a significant difference in creatinine (Cr) levels between the groups, and Cr correlated with BP in both groups. In group B, microalbuminuria correlated with ambulatory BP, and plasma renin activity failed to decrease with chronological age. Elevated load was shown in 8 of 50 patients in group A and in 21 of 50 in group B. In 3 of 12 patients of group B, with increased load BP, left ventricular geometry, by integrated backscatter, was abnormal. ABPM was useful in selected children at risk of hypertension. |
| doi_str_mv | 10.1007/s00467-003-1068-6 |
| format | Article |
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The patients, mean age of 13.5+/-5 years and almost 5 years of follow-up, were divided according to degree of RN into group A (I/II) and group B (III/IV). For each subject, 24-h systolic and diastolic BP (SBP-DBP), load (percentage of BP readings that exceeded the age- and sex-specific 95th percentile), and biochemical parameters were recorded. There was no significant difference in casual BP between the groups. The mean 24-h SBP-DBP and load were significantly higher in group B than A. There was a significant difference in creatinine (Cr) levels between the groups, and Cr correlated with BP in both groups. In group B, microalbuminuria correlated with ambulatory BP, and plasma renin activity failed to decrease with chronological age. Elevated load was shown in 8 of 50 patients in group A and in 21 of 50 in group B. In 3 of 12 patients of group B, with increased load BP, left ventricular geometry, by integrated backscatter, was abnormal. ABPM was useful in selected children at risk of hypertension.</description><identifier>ISSN: 0931-041X</identifier><identifier>EISSN: 1432-198X</identifier><identifier>DOI: 10.1007/s00467-003-1068-6</identifier><identifier>PMID: 12644916</identifier><identifier>CODEN: PENED3</identifier><language>eng</language><publisher>Heidelberg: Springer</publisher><subject>Adolescent ; Age ; Albuminuria - epidemiology ; Albuminuria - physiopathology ; Biological and medical sciences ; Blood pressure ; Blood Pressure Monitoring, Ambulatory ; Child ; Creatinine ; Creatinine - blood ; Female ; Follow-Up Studies ; Glomerular Filtration Rate ; Humans ; Hypertension ; Hypertension, Renal - diagnosis ; Hypertension, Renal - epidemiology ; Hypertension, Renal - physiopathology ; Kidneys ; Male ; Medical sciences ; Nephrology. Urinary tract diseases ; Pediatrics ; Retrospective Studies ; Risk Factors ; Scars ; Urinary system involvement in other diseases. 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The patients, mean age of 13.5+/-5 years and almost 5 years of follow-up, were divided according to degree of RN into group A (I/II) and group B (III/IV). For each subject, 24-h systolic and diastolic BP (SBP-DBP), load (percentage of BP readings that exceeded the age- and sex-specific 95th percentile), and biochemical parameters were recorded. There was no significant difference in casual BP between the groups. The mean 24-h SBP-DBP and load were significantly higher in group B than A. There was a significant difference in creatinine (Cr) levels between the groups, and Cr correlated with BP in both groups. In group B, microalbuminuria correlated with ambulatory BP, and plasma renin activity failed to decrease with chronological age. Elevated load was shown in 8 of 50 patients in group A and in 21 of 50 in group B. In 3 of 12 patients of group B, with increased load BP, left ventricular geometry, by integrated backscatter, was abnormal. ABPM was useful in selected children at risk of hypertension.</description><subject>Adolescent</subject><subject>Age</subject><subject>Albuminuria - epidemiology</subject><subject>Albuminuria - physiopathology</subject><subject>Biological and medical sciences</subject><subject>Blood pressure</subject><subject>Blood Pressure Monitoring, Ambulatory</subject><subject>Child</subject><subject>Creatinine</subject><subject>Creatinine - blood</subject><subject>Female</subject><subject>Follow-Up Studies</subject><subject>Glomerular Filtration Rate</subject><subject>Humans</subject><subject>Hypertension</subject><subject>Hypertension, Renal - diagnosis</subject><subject>Hypertension, Renal - epidemiology</subject><subject>Hypertension, Renal - physiopathology</subject><subject>Kidneys</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Nephrology. Urinary tract diseases</subject><subject>Pediatrics</subject><subject>Retrospective Studies</subject><subject>Risk Factors</subject><subject>Scars</subject><subject>Urinary system involvement in other diseases. 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Urinary tract diseases</topic><topic>Pediatrics</topic><topic>Retrospective Studies</topic><topic>Risk Factors</topic><topic>Scars</topic><topic>Urinary system involvement in other diseases. 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The patients, mean age of 13.5+/-5 years and almost 5 years of follow-up, were divided according to degree of RN into group A (I/II) and group B (III/IV). For each subject, 24-h systolic and diastolic BP (SBP-DBP), load (percentage of BP readings that exceeded the age- and sex-specific 95th percentile), and biochemical parameters were recorded. There was no significant difference in casual BP between the groups. The mean 24-h SBP-DBP and load were significantly higher in group B than A. There was a significant difference in creatinine (Cr) levels between the groups, and Cr correlated with BP in both groups. In group B, microalbuminuria correlated with ambulatory BP, and plasma renin activity failed to decrease with chronological age. Elevated load was shown in 8 of 50 patients in group A and in 21 of 50 in group B. In 3 of 12 patients of group B, with increased load BP, left ventricular geometry, by integrated backscatter, was abnormal. ABPM was useful in selected children at risk of hypertension.</abstract><cop>Heidelberg</cop><pub>Springer</pub><pmid>12644916</pmid><doi>10.1007/s00467-003-1068-6</doi><tpages>5</tpages></addata></record> |
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| identifier | ISSN: 0931-041X |
| ispartof | Pediatric nephrology (Berlin, West), 2003-03, Vol.18 (3), p.241-245 |
| issn | 0931-041X 1432-198X |
| language | eng |
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| source | MEDLINE; Springer Nature - Complete Springer Journals |
| subjects | Adolescent Age Albuminuria - epidemiology Albuminuria - physiopathology Biological and medical sciences Blood pressure Blood Pressure Monitoring, Ambulatory Child Creatinine Creatinine - blood Female Follow-Up Studies Glomerular Filtration Rate Humans Hypertension Hypertension, Renal - diagnosis Hypertension, Renal - epidemiology Hypertension, Renal - physiopathology Kidneys Male Medical sciences Nephrology. Urinary tract diseases Pediatrics Retrospective Studies Risk Factors Scars Urinary system involvement in other diseases. Miscellaneous Vesico-Ureteral Reflux - epidemiology Vesico-Ureteral Reflux - physiopathology |
| title | Reflux nephropathy and hypertension: COrrelation with the progression of renal damage |
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