Global Anticoagulant Effects of a Synthetic Anti-Factor Xa Inhibitor (DX-9065a): Implications for Interventional Use

Heparin has been conventionally used as an anticoagulant for medical and surgical indications. Because factor Xa is an essential component of the prothrombinase complex and leads to the generation of thrombin, its inhibition has become a focus of newer antithrombotic drug development. The in vitro a...

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Veröffentlicht in:	Clinical and applied thrombosis/hemostasis 2003-01, Vol.9 (1), p.1-17
Hauptverfasser:	Tobu, Mahmut, Iqbal, Omer, Ma, Qing, Schultz, Christopher, Jeske, Walter, Hoppensteadt, Debra, Lewis, Bruce, Fareed, Daniel, Fareed, Jawed
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine Diphosphate - pharmacology Animals Anticoagulants Anticoagulants - pharmacology Anticoagulants - therapeutic use Calibration Drug development Factor Xa Inhibitors Female Humans Macaca mulatta Male Naphthalenes - pharmacokinetics Naphthalenes - pharmacology Naphthalenes - therapeutic use Partial Thromboplastin Time Platelet Aggregation - drug effects Propionates - pharmacokinetics Propionates - pharmacology Propionates - therapeutic use Prothrombin Time Thrombin - metabolism Tissue Distribution
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