Antioxidant activity of different dihydropyridines

Lacidipine, a dihydropyridine-based calcium antagonist (DHP), has already been demonstrated to possess antioxidant activity and to reduce the intracellular production of reactive oxygen species (ROS). To verify if this effect is a peculiarity of this molecule, or belongs to other DHPs, the activity...

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Veröffentlicht in:	Biochemical and biophysical research communications 2003-03, Vol.302 (4), p.679-684
Hauptverfasser:	Cominacini, Luciano, Fratta Pasini, Anna, Garbin, Ulisse, Pastorino, Antonio M, Davoli, Anna, Nava, Cristina, Campagnola, Mario, Rossato, Paolo, Lo Cascio, V
Format:	Artikel
Sprache:	eng
Schlagworte:	Amlodipine - chemistry Amlodipine - metabolism Amlodipine - pharmacology Animals Antioxidants - chemistry Antioxidants - metabolism Antioxidants - pharmacology Atherosclerosis Cattle Cells, Cultured Dihydropyridines Dihydropyridines - chemistry Dihydropyridines - metabolism Dihydropyridines - pharmacology Endothelial cells Endothelium, Vascular - cytology Endothelium, Vascular - drug effects Endothelium, Vascular - metabolism Fluoresceins - metabolism Humans Lipoproteins, LDL - metabolism Molecular Structure Nifedipine - chemistry Nifedipine - metabolism Nifedipine - pharmacology Nimodipine - chemistry Nimodipine - metabolism Nimodipine - pharmacology Oxidized low density lipoprotein Reactive oxygen species Reactive Oxygen Species - metabolism
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