Study on protolytic equilibria of lorazepam and oxazepam by UV and NMR spectroscopy

Protolytic equilibria in homogeneous and heterogeneous systems of lorazepam and oxazepam, which are sparingly soluble ampholytes from the class of 1,4-benzodiazepines, were studied at 25 °C and ionic strength of 0.1 M. Acidity constants and equilibrium constants in a heterogeneous system were determ...

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Veröffentlicht in:	Journal of pharmaceutical and biomedical analysis 2003-03, Vol.31 (4), p.693-699
Hauptverfasser:	Popović, G.V, Sladić, D.M, Stefanović, V.M, Pfendt, L.B
Format:	Artikel
Sprache:	eng
Schlagworte:	Acidity constants Analysis Biological and medical sciences General pharmacology Lorazepam Lorazepam - analysis Lorazepam - chemistry Magnetic Resonance Spectroscopy - methods Medical sciences Oxazepam Oxazepam - analysis Oxazepam - chemistry Pharmacology. Drug treatments Solubility Spectrophotometry, Ultraviolet - methods
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