Preparation and structure-activity relationships of simplified analogs of the antifungal agent cilofungin: a total synthesis approach

The echinocandins are a well-known class of lipopeptides characterized by their potent antifungal activity against Candida species. The mechanism of action of the echinocandins is generally thought to be the inhibition of beta-1,3-glucan synthesis, an important structural component in the cell wall...

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Veröffentlicht in:	Journal of medicinal chemistry 1992-07, Vol.35 (15), p.2843-2855
Hauptverfasser:	Zambias, Robert A, Hammond, Milton L, Heck, James V, Bartizal, Ken, Trainor, Charlotte, Abruzzo, George, Schmatz, Dennis M, Nollstadt, Karl M
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Antifungal Agents - chemical synthesis Antifungal Agents - pharmacology beta-Glucans Candida - drug effects Chemistry Echinocandins Exact sciences and technology Glucans - biosynthesis Molecular Sequence Data Organic chemistry Peptides Peptides - chemical synthesis Peptides - pharmacology Peptides, Cyclic Preparations and properties Structure-Activity Relationship
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