In vivo anti-nociceptive and anti-inflammatory effect of the two triterpenes, ursolic acid and 23-hydroxyursolic acid, from Cussonia bancoensis
Triterpenoids, ursolic acid (1) and 23-hydroxyursolic acid (2) were obtained from the hydrolysis of BuOH fraction of Cussonia bancoensis extract to test antinociceptive and anti-inflammatory effect of C. bancoensis (Araliaceae). Compound 1 and 2 exhibited anti-nociceptive effects, which were determi...
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| Veröffentlicht in: | Archives of pharmacal research 2003-02, Vol.26 (2), p.143-146 |
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| container_title | Archives of pharmacal research |
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| creator | Tapondjou, L A Lontsi, David Sondengam, Beibam Luc Choi, Jongwon Lee, Kyung-Tae Jung, Hyun-Ju Park, Hee-Juhn |
| description | Triterpenoids, ursolic acid (1) and 23-hydroxyursolic acid (2) were obtained from the hydrolysis of BuOH fraction of Cussonia bancoensis extract to test antinociceptive and anti-inflammatory effect of C. bancoensis (Araliaceae). Compound 1 and 2 exhibited anti-nociceptive effects, which were determined by acetic acid-induced writhing test and hot plate test. The effect of 2 was much more potent in acetic acid-induced writhing test than in hot plate test. Compound 1 and 2 significantly inhibited 1%-carrageenan-induced edema in the rat. These results suggest that the two triterpenes, ursolic acid and 23-hydroxyursolic acid, are responsible for the anti-nociceptive and anti-inflammatory effect of C. bancoesnsis. |
| doi_str_mv | 10.1007/BF02976660 |
| format | Article |
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Compound 1 and 2 exhibited anti-nociceptive effects, which were determined by acetic acid-induced writhing test and hot plate test. The effect of 2 was much more potent in acetic acid-induced writhing test than in hot plate test. Compound 1 and 2 significantly inhibited 1%-carrageenan-induced edema in the rat. 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Compound 1 and 2 exhibited anti-nociceptive effects, which were determined by acetic acid-induced writhing test and hot plate test. The effect of 2 was much more potent in acetic acid-induced writhing test than in hot plate test. Compound 1 and 2 significantly inhibited 1%-carrageenan-induced edema in the rat. 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Compound 1 and 2 exhibited anti-nociceptive effects, which were determined by acetic acid-induced writhing test and hot plate test. The effect of 2 was much more potent in acetic acid-induced writhing test than in hot plate test. Compound 1 and 2 significantly inhibited 1%-carrageenan-induced edema in the rat. These results suggest that the two triterpenes, ursolic acid and 23-hydroxyursolic acid, are responsible for the anti-nociceptive and anti-inflammatory effect of C. bancoesnsis.</abstract><cop>Korea (South)</cop><pmid>12643591</pmid><doi>10.1007/BF02976660</doi><tpages>4</tpages></addata></record> |
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| ispartof | Archives of pharmacal research, 2003-02, Vol.26 (2), p.143-146 |
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| source | MEDLINE; SpringerNature Journals |
| subjects | Analgesics - chemistry Analgesics - isolation & purification Analgesics - therapeutic use Animals Anti-Inflammatory Agents, Non-Steroidal - chemistry Anti-Inflammatory Agents, Non-Steroidal - isolation & purification Anti-Inflammatory Agents, Non-Steroidal - therapeutic use Araliaceae - chemistry Disease Models, Animal Edema - drug therapy Korea Male Medicine, East Asian Traditional Mice Mice, Inbred ICR Molecular Structure Pain - drug therapy Plant Bark - chemistry Plant Extracts Plant Leaves - chemistry Rats Rats, Sprague-Dawley Triterpenes - chemistry Triterpenes - isolation & purification Triterpenes - therapeutic use Ursolic Acid |
| title | In vivo anti-nociceptive and anti-inflammatory effect of the two triterpenes, ursolic acid and 23-hydroxyursolic acid, from Cussonia bancoensis |
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