Antizyme is a target of sex-lethal in the drosophila germline and appears to act downstream of hedgehog to regulate sex-lethal and cyclin B
The sex determination master switch, Sex-lethal, has been shown to regulate the mitosis of early germ cells in Drosophila melanogaster. Sex-lethal is an RNA binding protein that regulates splicing and translation of specific targets in the soma, but the germline targets are unknown. In an experiment...
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| Veröffentlicht in: | Developmental biology 2003-01, Vol.253 (2), p.214-229 |
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| creator | Vied, Cynthia Halachmi, Naomi Salzberg, Adi Horabin, Jamila I |
| description | The sex determination master switch,
Sex-lethal, has been shown to regulate the mitosis of early germ cells in
Drosophila melanogaster. Sex-lethal is an RNA binding protein that regulates splicing and translation of specific targets in the soma, but the germline targets are unknown. In an experiment aimed at identifying targets of Sex-lethal in early germ cells, the RNA encoded by
gutfeeling, the
Drosophila homolog of Ornithine Decarboxylase Antizyme, was isolated.
gutfeeling interacts genetically with
Sex-lethal. It is not only a target of Sex-lethal, but also appears to regulate the nuclear entry and overall levels of Sex-lethal in early germ cells. This regulation of Sex-lethal by
gutfeeling appears to occur downstream of the Hedgehog signal. We also show that Hedgehog, Gutfeeling, and Sex-lethal function to regulate Cyclin B, providing a link between Sex-lethal and mitosis. |
| doi_str_mv | 10.1016/S0012-1606(02)00012-X |
| format | Article |
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Sex-lethal, has been shown to regulate the mitosis of early germ cells in
Drosophila melanogaster. Sex-lethal is an RNA binding protein that regulates splicing and translation of specific targets in the soma, but the germline targets are unknown. In an experiment aimed at identifying targets of Sex-lethal in early germ cells, the RNA encoded by
gutfeeling, the
Drosophila homolog of Ornithine Decarboxylase Antizyme, was isolated.
gutfeeling interacts genetically with
Sex-lethal. It is not only a target of Sex-lethal, but also appears to regulate the nuclear entry and overall levels of Sex-lethal in early germ cells. This regulation of Sex-lethal by
gutfeeling appears to occur downstream of the Hedgehog signal. We also show that Hedgehog, Gutfeeling, and Sex-lethal function to regulate Cyclin B, providing a link between Sex-lethal and mitosis.</description><identifier>ISSN: 0012-1606</identifier><identifier>EISSN: 1095-564X</identifier><identifier>DOI: 10.1016/S0012-1606(02)00012-X</identifier><identifier>PMID: 12645926</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Animals ; Animals, Genetically Modified ; Antizyme ; Base Sequence ; Cyclin B ; Cyclin B - genetics ; Drosophila ; Drosophila melanogaster - embryology ; Drosophila melanogaster - genetics ; Drosophila Proteins - genetics ; Female ; Gene Expression Regulation, Developmental ; Genes, Insect ; Germ Cells - cytology ; Germ Cells - metabolism ; Hedgehog ; Hedgehog Proteins ; Hot Temperature ; Male ; Models, Biological ; Mutation ; Oogenesis ; Oogenesis - genetics ; Proteins - genetics ; RNA - genetics ; RNA-Binding Proteins - genetics ; Sex Determination Processes ; Sex Differentiation - genetics ; Sex-lethal</subject><ispartof>Developmental biology, 2003-01, Vol.253 (2), p.214-229</ispartof><rights>2003 Elsevier Science (USA)</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c439t-281349872dfd06ef9a6ee01f5f5a0ae0e06f17b16b35ae317b2680379f54037f3</citedby><cites>FETCH-LOGICAL-c439t-281349872dfd06ef9a6ee01f5f5a0ae0e06f17b16b35ae317b2680379f54037f3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/S0012-1606(02)00012-X$$EHTML$$P50$$Gelsevier$$Hfree_for_read</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/12645926$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Vied, Cynthia</creatorcontrib><creatorcontrib>Halachmi, Naomi</creatorcontrib><creatorcontrib>Salzberg, Adi</creatorcontrib><creatorcontrib>Horabin, Jamila I</creatorcontrib><title>Antizyme is a target of sex-lethal in the drosophila germline and appears to act downstream of hedgehog to regulate sex-lethal and cyclin B</title><title>Developmental biology</title><addtitle>Dev Biol</addtitle><description>The sex determination master switch,
Sex-lethal, has been shown to regulate the mitosis of early germ cells in
Drosophila melanogaster. Sex-lethal is an RNA binding protein that regulates splicing and translation of specific targets in the soma, but the germline targets are unknown. In an experiment aimed at identifying targets of Sex-lethal in early germ cells, the RNA encoded by
gutfeeling, the
Drosophila homolog of Ornithine Decarboxylase Antizyme, was isolated.
gutfeeling interacts genetically with
Sex-lethal. It is not only a target of Sex-lethal, but also appears to regulate the nuclear entry and overall levels of Sex-lethal in early germ cells. This regulation of Sex-lethal by
gutfeeling appears to occur downstream of the Hedgehog signal. We also show that Hedgehog, Gutfeeling, and Sex-lethal function to regulate Cyclin B, providing a link between Sex-lethal and mitosis.</description><subject>Animals</subject><subject>Animals, Genetically Modified</subject><subject>Antizyme</subject><subject>Base Sequence</subject><subject>Cyclin B</subject><subject>Cyclin B - genetics</subject><subject>Drosophila</subject><subject>Drosophila melanogaster - embryology</subject><subject>Drosophila melanogaster - genetics</subject><subject>Drosophila Proteins - genetics</subject><subject>Female</subject><subject>Gene Expression Regulation, Developmental</subject><subject>Genes, Insect</subject><subject>Germ Cells - cytology</subject><subject>Germ Cells - metabolism</subject><subject>Hedgehog</subject><subject>Hedgehog Proteins</subject><subject>Hot Temperature</subject><subject>Male</subject><subject>Models, Biological</subject><subject>Mutation</subject><subject>Oogenesis</subject><subject>Oogenesis - genetics</subject><subject>Proteins - genetics</subject><subject>RNA - genetics</subject><subject>RNA-Binding Proteins - genetics</subject><subject>Sex Determination Processes</subject><subject>Sex Differentiation - genetics</subject><subject>Sex-lethal</subject><issn>0012-1606</issn><issn>1095-564X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2003</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkU2LFDEQhoMo7rj6E5ScRA-tlaQ73X2SdfELFjyoMLeQSSrdkf4yyajjX_BPm54Z1NueKqGeegrqJeQxgxcMmHz5CYDxgkmQz4A_h-Nve4dsGLRVUclye5ds_iIX5EGMXzMkmkbcJxeMy7JqudyQ31dT8r8OI1IfqaZJhw4TnR2N-LMYMPV6oH6iqUdqwxznpfeDph2GcfATUj1ZqpcFdYg0zVSbRO38Y4opoB5XTY-2w37u1m7Abj_ohP-7V4E5mCyjrx-Se04PER-d6yX58vbN5-v3xc3Hdx-ur24KU4o2FbxhomybmltnQaJrtUQE5ipXadAICNKxesfkTlQaRX5y2YCoW1eVuThxSZ6evEuYv-0xJjX6aHAY9ITzPqpaMMZ42d4KskbWwEFmsDqBJt8oBnRqCX7U4aAYqDUudYxLrVko4OoYl9rmuSfnBfvdiPbf1DmfDLw6AZjv8d1jUNF4nAxaH9AkZWd_y4o_MsKlqg</recordid><startdate>20030115</startdate><enddate>20030115</enddate><creator>Vied, Cynthia</creator><creator>Halachmi, Naomi</creator><creator>Salzberg, Adi</creator><creator>Horabin, Jamila I</creator><general>Elsevier Inc</general><scope>6I.</scope><scope>AAFTH</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7SS</scope><scope>7TM</scope><scope>7X8</scope></search><sort><creationdate>20030115</creationdate><title>Antizyme is a target of sex-lethal in the drosophila germline and appears to act downstream of hedgehog to regulate sex-lethal and cyclin B</title><author>Vied, Cynthia ; Halachmi, Naomi ; Salzberg, Adi ; Horabin, Jamila I</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c439t-281349872dfd06ef9a6ee01f5f5a0ae0e06f17b16b35ae317b2680379f54037f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2003</creationdate><topic>Animals</topic><topic>Animals, Genetically Modified</topic><topic>Antizyme</topic><topic>Base Sequence</topic><topic>Cyclin B</topic><topic>Cyclin B - genetics</topic><topic>Drosophila</topic><topic>Drosophila melanogaster - embryology</topic><topic>Drosophila melanogaster - genetics</topic><topic>Drosophila Proteins - genetics</topic><topic>Female</topic><topic>Gene Expression Regulation, Developmental</topic><topic>Genes, Insect</topic><topic>Germ Cells - cytology</topic><topic>Germ Cells - metabolism</topic><topic>Hedgehog</topic><topic>Hedgehog Proteins</topic><topic>Hot Temperature</topic><topic>Male</topic><topic>Models, Biological</topic><topic>Mutation</topic><topic>Oogenesis</topic><topic>Oogenesis - genetics</topic><topic>Proteins - genetics</topic><topic>RNA - genetics</topic><topic>RNA-Binding Proteins - genetics</topic><topic>Sex Determination Processes</topic><topic>Sex Differentiation - genetics</topic><topic>Sex-lethal</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Vied, Cynthia</creatorcontrib><creatorcontrib>Halachmi, Naomi</creatorcontrib><creatorcontrib>Salzberg, Adi</creatorcontrib><creatorcontrib>Horabin, Jamila I</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Entomology Abstracts (Full archive)</collection><collection>Nucleic Acids Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Developmental biology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Vied, Cynthia</au><au>Halachmi, Naomi</au><au>Salzberg, Adi</au><au>Horabin, Jamila I</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Antizyme is a target of sex-lethal in the drosophila germline and appears to act downstream of hedgehog to regulate sex-lethal and cyclin B</atitle><jtitle>Developmental biology</jtitle><addtitle>Dev Biol</addtitle><date>2003-01-15</date><risdate>2003</risdate><volume>253</volume><issue>2</issue><spage>214</spage><epage>229</epage><pages>214-229</pages><issn>0012-1606</issn><eissn>1095-564X</eissn><abstract>The sex determination master switch,
Sex-lethal, has been shown to regulate the mitosis of early germ cells in
Drosophila melanogaster. Sex-lethal is an RNA binding protein that regulates splicing and translation of specific targets in the soma, but the germline targets are unknown. In an experiment aimed at identifying targets of Sex-lethal in early germ cells, the RNA encoded by
gutfeeling, the
Drosophila homolog of Ornithine Decarboxylase Antizyme, was isolated.
gutfeeling interacts genetically with
Sex-lethal. It is not only a target of Sex-lethal, but also appears to regulate the nuclear entry and overall levels of Sex-lethal in early germ cells. This regulation of Sex-lethal by
gutfeeling appears to occur downstream of the Hedgehog signal. We also show that Hedgehog, Gutfeeling, and Sex-lethal function to regulate Cyclin B, providing a link between Sex-lethal and mitosis.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>12645926</pmid><doi>10.1016/S0012-1606(02)00012-X</doi><tpages>16</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Developmental biology, 2003-01, Vol.253 (2), p.214-229 |
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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Access via ScienceDirect (Elsevier) |
| subjects | Animals Animals, Genetically Modified Antizyme Base Sequence Cyclin B Cyclin B - genetics Drosophila Drosophila melanogaster - embryology Drosophila melanogaster - genetics Drosophila Proteins - genetics Female Gene Expression Regulation, Developmental Genes, Insect Germ Cells - cytology Germ Cells - metabolism Hedgehog Hedgehog Proteins Hot Temperature Male Models, Biological Mutation Oogenesis Oogenesis - genetics Proteins - genetics RNA - genetics RNA-Binding Proteins - genetics Sex Determination Processes Sex Differentiation - genetics Sex-lethal |
| title | Antizyme is a target of sex-lethal in the drosophila germline and appears to act downstream of hedgehog to regulate sex-lethal and cyclin B |
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