Innervation of the paralyzed laryngeal muscles by phrenic motoneurons. A quantitative study by light and electron microscopy
In the cat, inspiratory opening of the paralyzed glottis recovered after unilateral or bilateral reinnervation of the posterior cricoarytenoid (PCA) muscles by phrenic axons. The morphometric analysis of the regenerated recurrent laryngeal nerves (RLNs), showed that proliferation was abundant; 4 mon...
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| Veröffentlicht in: | The Laryngoscope 1992-08, Vol.102 (8), p.907-916 |
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| container_title | The Laryngoscope |
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| creator | Baldissera, F. Tredici, G. Marini, G. Fiori, M. G. Cantarella, G. Ottaviani, F. Zanoni, R. |
| description | In the cat, inspiratory opening of the paralyzed glottis recovered after unilateral or bilateral reinnervation of the posterior cricoarytenoid (PCA) muscles by phrenic axons. The morphometric analysis of the regenerated recurrent laryngeal nerves (RLNs), showed that proliferation was abundant; 4 months after the nerve anastomosis, more than 500 myelinated axonal branches repopulated the RLNs. The mean diameter of motor axons (3.5 to 5.0 μm) was lower than in normal phrenic and RLN (8 to 10 μm), and the mean internode length was about half that of the normal RLN. Histochemical examination of the PCA muscle revealed that muscle fiber composition (44% type I and 56% type II muscle fiber) was fairly similar to that of normal PCA. The contraction time of the reinnervated muscles was as long as 60 msec at the time of movement recovery, but it shortened to 25 to 30 msec when the reinnervation time increased. These anatomical and functional results support the choice of the phrenic nerve for laryngeal reinnervation. |
| doi_str_mv | 10.1288/00005537-199208000-00011 |
| format | Article |
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A quantitative study by light and electron microscopy</title><source>MEDLINE</source><source>Journals@Ovid Ovid Autoload</source><creator>Baldissera, F. ; Tredici, G. ; Marini, G. ; Fiori, M. G. ; Cantarella, G. ; Ottaviani, F. ; Zanoni, R.</creator><creatorcontrib>Baldissera, F. ; Tredici, G. ; Marini, G. ; Fiori, M. G. ; Cantarella, G. ; Ottaviani, F. ; Zanoni, R.</creatorcontrib><description>In the cat, inspiratory opening of the paralyzed glottis recovered after unilateral or bilateral reinnervation of the posterior cricoarytenoid (PCA) muscles by phrenic axons. The morphometric analysis of the regenerated recurrent laryngeal nerves (RLNs), showed that proliferation was abundant; 4 months after the nerve anastomosis, more than 500 myelinated axonal branches repopulated the RLNs. The mean diameter of motor axons (3.5 to 5.0 μm) was lower than in normal phrenic and RLN (8 to 10 μm), and the mean internode length was about half that of the normal RLN. Histochemical examination of the PCA muscle revealed that muscle fiber composition (44% type I and 56% type II muscle fiber) was fairly similar to that of normal PCA. The contraction time of the reinnervated muscles was as long as 60 msec at the time of movement recovery, but it shortened to 25 to 30 msec when the reinnervation time increased. These anatomical and functional results support the choice of the phrenic nerve for laryngeal reinnervation.</description><identifier>ISSN: 0023-852X</identifier><identifier>EISSN: 1531-4995</identifier><identifier>DOI: 10.1288/00005537-199208000-00011</identifier><identifier>PMID: 1386642</identifier><identifier>CODEN: LARYA8</identifier><language>eng</language><publisher>Hoboken, NJ: John Wiley & Sons, Inc</publisher><subject>Adenosine Triphosphatases - analysis ; Anastomosis, Surgical ; Animals ; Axons - physiology ; Axons - ultrastructure ; Biological and medical sciences ; Cats ; Electromyography ; Laryngeal Muscles - innervation ; Laryngeal Muscles - pathology ; Medical sciences ; Microscopy, Electron ; Motor Neurons - cytology ; Motor Neurons - physiology ; Myofibrils - ultrastructure ; Nerve Endings - ultrastructure ; Nerve Fibers - ultrastructure ; Nerve Fibers, Myelinated - ultrastructure ; Nerve Regeneration ; Neuromuscular Junction - physiology ; Neuromuscular Junction - ultrastructure ; Non tumoral diseases ; Otorhinolaryngology. Stomatology ; Oxidoreductases - analysis ; Phrenic Nerve - pathology ; Phrenic Nerve - physiopathology ; Phrenic Nerve - surgery ; Reaction Time ; Recurrent Laryngeal Nerve - pathology ; Recurrent Laryngeal Nerve - physiopathology ; Recurrent Laryngeal Nerve - surgery ; Upper respiratory tract, upper alimentary tract, paranasal sinuses, salivary glands: diseases, semeiology ; Vocal Cord Paralysis - pathology ; Vocal Cord Paralysis - surgery</subject><ispartof>The Laryngoscope, 1992-08, Vol.102 (8), p.907-916</ispartof><rights>Copyright © 1992 The Triological Society</rights><rights>1992 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5831-3d50ad45ef9ff9394d4afcaf8bb0aea1717ac1cafbd1291bb2af9d94ffd7a58a3</citedby><cites>FETCH-LOGICAL-c5831-3d50ad45ef9ff9394d4afcaf8bb0aea1717ac1cafbd1291bb2af9d94ffd7a58a3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27903,27904</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=5506290$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/1386642$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Baldissera, F.</creatorcontrib><creatorcontrib>Tredici, G.</creatorcontrib><creatorcontrib>Marini, G.</creatorcontrib><creatorcontrib>Fiori, M. G.</creatorcontrib><creatorcontrib>Cantarella, G.</creatorcontrib><creatorcontrib>Ottaviani, F.</creatorcontrib><creatorcontrib>Zanoni, R.</creatorcontrib><title>Innervation of the paralyzed laryngeal muscles by phrenic motoneurons. A quantitative study by light and electron microscopy</title><title>The Laryngoscope</title><addtitle>The Laryngoscope</addtitle><description>In the cat, inspiratory opening of the paralyzed glottis recovered after unilateral or bilateral reinnervation of the posterior cricoarytenoid (PCA) muscles by phrenic axons. The morphometric analysis of the regenerated recurrent laryngeal nerves (RLNs), showed that proliferation was abundant; 4 months after the nerve anastomosis, more than 500 myelinated axonal branches repopulated the RLNs. The mean diameter of motor axons (3.5 to 5.0 μm) was lower than in normal phrenic and RLN (8 to 10 μm), and the mean internode length was about half that of the normal RLN. Histochemical examination of the PCA muscle revealed that muscle fiber composition (44% type I and 56% type II muscle fiber) was fairly similar to that of normal PCA. The contraction time of the reinnervated muscles was as long as 60 msec at the time of movement recovery, but it shortened to 25 to 30 msec when the reinnervation time increased. These anatomical and functional results support the choice of the phrenic nerve for laryngeal reinnervation.</description><subject>Adenosine Triphosphatases - analysis</subject><subject>Anastomosis, Surgical</subject><subject>Animals</subject><subject>Axons - physiology</subject><subject>Axons - ultrastructure</subject><subject>Biological and medical sciences</subject><subject>Cats</subject><subject>Electromyography</subject><subject>Laryngeal Muscles - innervation</subject><subject>Laryngeal Muscles - pathology</subject><subject>Medical sciences</subject><subject>Microscopy, Electron</subject><subject>Motor Neurons - cytology</subject><subject>Motor Neurons - physiology</subject><subject>Myofibrils - ultrastructure</subject><subject>Nerve Endings - ultrastructure</subject><subject>Nerve Fibers - ultrastructure</subject><subject>Nerve Fibers, Myelinated - ultrastructure</subject><subject>Nerve Regeneration</subject><subject>Neuromuscular Junction - physiology</subject><subject>Neuromuscular Junction - ultrastructure</subject><subject>Non tumoral diseases</subject><subject>Otorhinolaryngology. Stomatology</subject><subject>Oxidoreductases - analysis</subject><subject>Phrenic Nerve - pathology</subject><subject>Phrenic Nerve - physiopathology</subject><subject>Phrenic Nerve - surgery</subject><subject>Reaction Time</subject><subject>Recurrent Laryngeal Nerve - pathology</subject><subject>Recurrent Laryngeal Nerve - physiopathology</subject><subject>Recurrent Laryngeal Nerve - surgery</subject><subject>Upper respiratory tract, upper alimentary tract, paranasal sinuses, salivary glands: diseases, semeiology</subject><subject>Vocal Cord Paralysis - pathology</subject><subject>Vocal Cord Paralysis - surgery</subject><issn>0023-852X</issn><issn>1531-4995</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1992</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkFGP1CAQx4nRnOvpRzDhwfjWE9rSwuNmPfcubjQxGvWJTCncVintAT2t8cPLXtf1VRJCmPnNf2b-CGFKLmjO-SuSDmNFnVEhcsLTL0uX0gdoRVlBs1II9hCtCMmLjLP8y2P0JIRviagLRs7QGS14VZX5Cv2-dk77O4jd4PBgcNxrPIIHO__SLbbgZ3ejweJ-CsrqgJsZj3uvXadwP8TB6ckPLlzgNb6dwMUuJqU7jUOc2vkA2-5mHzG4FmurVUww7jvlh6CGcX6KHhmwQT87vufo05vLj5urbPd-e71Z7zLFeFqmaBmBtmTaCGNEIcq2BKPA8KYhoIHWtAZFU6BpaS5o0-RgRCtKY9oaGIfiHL1cdEc_3E46RNl3QWlrwelhCrIuKCXJyATyBTxMGLw2cvRdn0yQlMiD8fKv8fJkvLw3PpU-P_aYml63_woXp1P-xTEPQYE1HpzqwgljjFS5IAl7vWA_Oqvn_24vd-sPXxkrKUnR-2myRaYLUf88yYD_Lqu6qJn8_G4rN9Xbqy2jPO3_B2b_sMQ</recordid><startdate>199208</startdate><enddate>199208</enddate><creator>Baldissera, F.</creator><creator>Tredici, G.</creator><creator>Marini, G.</creator><creator>Fiori, M. G.</creator><creator>Cantarella, G.</creator><creator>Ottaviani, F.</creator><creator>Zanoni, R.</creator><general>John Wiley & Sons, Inc</general><general>Wiley-Blackwell</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>8BM</scope></search><sort><creationdate>199208</creationdate><title>Innervation of the paralyzed laryngeal muscles by phrenic motoneurons. A quantitative study by light and electron microscopy</title><author>Baldissera, F. ; Tredici, G. ; Marini, G. ; Fiori, M. G. ; Cantarella, G. ; Ottaviani, F. ; Zanoni, R.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5831-3d50ad45ef9ff9394d4afcaf8bb0aea1717ac1cafbd1291bb2af9d94ffd7a58a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1992</creationdate><topic>Adenosine Triphosphatases - analysis</topic><topic>Anastomosis, Surgical</topic><topic>Animals</topic><topic>Axons - physiology</topic><topic>Axons - ultrastructure</topic><topic>Biological and medical sciences</topic><topic>Cats</topic><topic>Electromyography</topic><topic>Laryngeal Muscles - innervation</topic><topic>Laryngeal Muscles - pathology</topic><topic>Medical sciences</topic><topic>Microscopy, Electron</topic><topic>Motor Neurons - cytology</topic><topic>Motor Neurons - physiology</topic><topic>Myofibrils - ultrastructure</topic><topic>Nerve Endings - ultrastructure</topic><topic>Nerve Fibers - ultrastructure</topic><topic>Nerve Fibers, Myelinated - ultrastructure</topic><topic>Nerve Regeneration</topic><topic>Neuromuscular Junction - physiology</topic><topic>Neuromuscular Junction - ultrastructure</topic><topic>Non tumoral diseases</topic><topic>Otorhinolaryngology. Stomatology</topic><topic>Oxidoreductases - analysis</topic><topic>Phrenic Nerve - pathology</topic><topic>Phrenic Nerve - physiopathology</topic><topic>Phrenic Nerve - surgery</topic><topic>Reaction Time</topic><topic>Recurrent Laryngeal Nerve - pathology</topic><topic>Recurrent Laryngeal Nerve - physiopathology</topic><topic>Recurrent Laryngeal Nerve - surgery</topic><topic>Upper respiratory tract, upper alimentary tract, paranasal sinuses, salivary glands: diseases, semeiology</topic><topic>Vocal Cord Paralysis - pathology</topic><topic>Vocal Cord Paralysis - surgery</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Baldissera, F.</creatorcontrib><creatorcontrib>Tredici, G.</creatorcontrib><creatorcontrib>Marini, G.</creatorcontrib><creatorcontrib>Fiori, M. G.</creatorcontrib><creatorcontrib>Cantarella, G.</creatorcontrib><creatorcontrib>Ottaviani, F.</creatorcontrib><creatorcontrib>Zanoni, R.</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>ComDisDome</collection><jtitle>The Laryngoscope</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Baldissera, F.</au><au>Tredici, G.</au><au>Marini, G.</au><au>Fiori, M. G.</au><au>Cantarella, G.</au><au>Ottaviani, F.</au><au>Zanoni, R.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Innervation of the paralyzed laryngeal muscles by phrenic motoneurons. A quantitative study by light and electron microscopy</atitle><jtitle>The Laryngoscope</jtitle><addtitle>The Laryngoscope</addtitle><date>1992-08</date><risdate>1992</risdate><volume>102</volume><issue>8</issue><spage>907</spage><epage>916</epage><pages>907-916</pages><issn>0023-852X</issn><eissn>1531-4995</eissn><coden>LARYA8</coden><abstract>In the cat, inspiratory opening of the paralyzed glottis recovered after unilateral or bilateral reinnervation of the posterior cricoarytenoid (PCA) muscles by phrenic axons. The morphometric analysis of the regenerated recurrent laryngeal nerves (RLNs), showed that proliferation was abundant; 4 months after the nerve anastomosis, more than 500 myelinated axonal branches repopulated the RLNs. The mean diameter of motor axons (3.5 to 5.0 μm) was lower than in normal phrenic and RLN (8 to 10 μm), and the mean internode length was about half that of the normal RLN. Histochemical examination of the PCA muscle revealed that muscle fiber composition (44% type I and 56% type II muscle fiber) was fairly similar to that of normal PCA. The contraction time of the reinnervated muscles was as long as 60 msec at the time of movement recovery, but it shortened to 25 to 30 msec when the reinnervation time increased. These anatomical and functional results support the choice of the phrenic nerve for laryngeal reinnervation.</abstract><cop>Hoboken, NJ</cop><pub>John Wiley & Sons, Inc</pub><pmid>1386642</pmid><doi>10.1288/00005537-199208000-00011</doi><tpages>10</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | The Laryngoscope, 1992-08, Vol.102 (8), p.907-916 |
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| language | eng |
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| source | MEDLINE; Journals@Ovid Ovid Autoload |
| subjects | Adenosine Triphosphatases - analysis Anastomosis, Surgical Animals Axons - physiology Axons - ultrastructure Biological and medical sciences Cats Electromyography Laryngeal Muscles - innervation Laryngeal Muscles - pathology Medical sciences Microscopy, Electron Motor Neurons - cytology Motor Neurons - physiology Myofibrils - ultrastructure Nerve Endings - ultrastructure Nerve Fibers - ultrastructure Nerve Fibers, Myelinated - ultrastructure Nerve Regeneration Neuromuscular Junction - physiology Neuromuscular Junction - ultrastructure Non tumoral diseases Otorhinolaryngology. Stomatology Oxidoreductases - analysis Phrenic Nerve - pathology Phrenic Nerve - physiopathology Phrenic Nerve - surgery Reaction Time Recurrent Laryngeal Nerve - pathology Recurrent Laryngeal Nerve - physiopathology Recurrent Laryngeal Nerve - surgery Upper respiratory tract, upper alimentary tract, paranasal sinuses, salivary glands: diseases, semeiology Vocal Cord Paralysis - pathology Vocal Cord Paralysis - surgery |
| title | Innervation of the paralyzed laryngeal muscles by phrenic motoneurons. A quantitative study by light and electron microscopy |
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