Expression of the interleukin-2 receptor on human fibroblasts and its biological significance

In this study, we have investigated the expression of the α and β chains of the IL-2 receptor (IL-2Rα, IL-2Rβ) both at the membrane and at transcrlptlonal levels during the lifespan of human embryonic fibroblasts. Here we show that the mAbs I0T14 and MIKβ1 directed against the IL-2 binding sites of...

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Veröffentlicht in:	International immunology 1992-07, Vol.4 (7), p.739-746
Hauptverfasser:	Plaisance, Stéphane, Rubinstein, Eric, Allleche, Abdelkrim, Sahraoui, Yasmina, Krief, Patricia, Augery-Bourget, Yvette, Jasmine, Claude, Suarez, Horacio, Azzarone, Bruno
Format:	Artikel
Sprache:	eng
Schlagworte:	aging Analysis of the immune response. Humoral and cellular immunity Biological and medical sciences Cell Adhesion Molecules - metabolism Cell Line Down-Regulation fibroblasts Fibroblasts - immunology Fundamental and applied biological sciences. Psychology Fundamental immunology Gene Expression Humans ICAM-1 IL-2 IL-2R IL-2Rα IL-2Rβ Immunobiology Intercellular Adhesion Molecule-1 Kinetics Lymphokines, interleukins ( function, expression) Receptors, Interleukin-2 - genetics Receptors, Interleukin-2 - metabolism Regulatory factors and their cellular receptors RNA - genetics RNA - metabolism
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