Nonbenzamidine isoxazoline derivatives as factor Xa inhibitors

Factor Xa (fXa) is an important serine protease in the blood coagulation cascade. Inhibition of fXa has emerged as an attractive target for potential therapeutic applications in the treatments of both arterial and venous thrombosis. Herein, we describe a series of non-benzamidine isoxazoline derivat...

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Veröffentlicht in:	Bioorganic & medicinal chemistry letters 2003-03, Vol.13 (6), p.1023-1028
Hauptverfasser:	Quan, Mimi L., Ellis, Christopher D., He, Ming Y., Liauw, Ann Y., Lam, Patrick Y.S., Rossi, Karen A., Knabb, Robert M., Luettgen, Joseph M., Wright, Matthew R., Wong, Pancras C., Wexler, Ruth R.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Biological Availability Blood. Blood coagulation. Reticuloendothelial system Chromatography, High Pressure Liquid Dogs Factor Xa Inhibitors Fibrinolytic Agents - chemical synthesis Fibrinolytic Agents - pharmacokinetics Fibrinolytic Agents - pharmacology Half-Life Humans In Vitro Techniques Indicators and Reagents Isoxazoles - chemical synthesis Isoxazoles - pharmacokinetics Isoxazoles - pharmacology Kinetics Medical sciences Models, Molecular Pharmacology. Drug treatments Rabbits
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