Role of the smoking-induced cytochrome P450 (CYP)1A2 and polymorphic CYP2D6 in steady-state concentration of olanzapine

This study investigated whether the smokinginducible cytochrome P450 (CYP) 1A2 and the polymorphic CYP2D6 play significant roles in the metabolism of olanzapine and its clinical effects at steady-state treatment. Caffeine and debrisoquine were used as measures of CYP1A2 and CYP2D6, respectively. Aft...

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Veröffentlicht in:	Journal of clinical psychopharmacology 2003-04, Vol.23 (2), p.119-127
Hauptverfasser:	CARRILLO, Juan Antonio, HERRAIZ, Angustias G, RAMOS, Sara Isabel, GERVASINI, Guillermo, VIZCAINO, Sonia, BENITEZ, Julio
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Antipsychotic Agents - blood Antipsychotic Agents - pharmacokinetics Antipsychotic Agents - therapeutic use Benzodiazepines Biological and medical sciences Caffeine - metabolism Caffeine - pharmacology Chromatography, High Pressure Liquid Cytochrome P-450 CYP1A2 - metabolism Cytochrome P-450 CYP2D6 - genetics Cytochrome P-450 CYP2D6 - metabolism Female Humans Male Medical sciences Middle Aged Neuropharmacology Olanzapine Pharmacology. Drug treatments Pirenzepine - analogs & derivatives Pirenzepine - blood Pirenzepine - pharmacokinetics Pirenzepine - therapeutic use Polymorphism, Genetic Psycholeptics: tranquillizer, neuroleptic Psychology. Psychoanalysis. Psychiatry Psychopharmacology Schizophrenia - drug therapy Schizophrenia - metabolism Sex Factors Smoking Spectrometry, Mass, Electrospray Ionization Tobacco, tobacco smoking Toxicology
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