Neuropeptide Y paradoxically increases food intake yet causes conditioned flavor aversions
Neuropeptides have been implicated in the short-term regulation of food intake and the long-term control of body weight. Previous studies have shown that central administration of neuropeptide Y (NPY), the most abundant of these peptides in the brain, produces robust increases of food intake. We now...
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Veröffentlicht in: | Physiology & behavior 1992-06, Vol.51 (6), p.1257-1260 |
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creator | Sipols, Alfred J. Brief, Deborah J. Ginter, Kari L. Saghafi, Saman Woods, Stephen C. |
description | Neuropeptides have been implicated in the short-term regulation of food intake and the long-term control of body weight. Previous studies have shown that central administration of neuropeptide Y (NPY), the most abundant of these peptides in the brain, produces robust increases of food intake. We now report that NPY, at doses that stimulate food intake when administered intraventricularly, also causes the formation of robust conditioned flavor aversions when given via the same cannula and at the same dose. This apparently paradoxical effect may be indicative of different populations of central NPY receptors having dissimilar effects on ingestive behaviors. The results also suggest that the use of conditioned aversions to investigate drug-induced malaise may not be appropriate when applied to ingestive behaviors. |
doi_str_mv | 10.1016/0031-9384(92)90317-U |
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Previous studies have shown that central administration of neuropeptide Y (NPY), the most abundant of these peptides in the brain, produces robust increases of food intake. We now report that NPY, at doses that stimulate food intake when administered intraventricularly, also causes the formation of robust conditioned flavor aversions when given via the same cannula and at the same dose. This apparently paradoxical effect may be indicative of different populations of central NPY receptors having dissimilar effects on ingestive behaviors. 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Previous studies have shown that central administration of neuropeptide Y (NPY), the most abundant of these peptides in the brain, produces robust increases of food intake. We now report that NPY, at doses that stimulate food intake when administered intraventricularly, also causes the formation of robust conditioned flavor aversions when given via the same cannula and at the same dose. This apparently paradoxical effect may be indicative of different populations of central NPY receptors having dissimilar effects on ingestive behaviors. The results also suggest that the use of conditioned aversions to investigate drug-induced malaise may not be appropriate when applied to ingestive behaviors.</description><subject>Animals</subject><subject>Behavioral psychophysiology</subject><subject>Biological and medical sciences</subject><subject>Conditioned flavor aversion</subject><subject>Conditioning, Operant - drug effects</subject><subject>Eating - drug effects</subject><subject>Food intake</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Injections, Intraventricular</subject><subject>Long-Evans rats</subject><subject>Male</subject><subject>Neuropeptide Y</subject><subject>Neuropeptide Y - pharmacology</subject><subject>Neurotransmission and behavior</subject><subject>Psychology. Psychoanalysis. Psychiatry</subject><subject>Psychology. 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Psychophysiology</topic><topic>Rats</topic><topic>Taste - drug effects</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Sipols, Alfred J.</creatorcontrib><creatorcontrib>Brief, Deborah J.</creatorcontrib><creatorcontrib>Ginter, Kari L.</creatorcontrib><creatorcontrib>Saghafi, Saman</creatorcontrib><creatorcontrib>Woods, Stephen C.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Animal Behavior Abstracts</collection><collection>Chemoreception Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Physiology & behavior</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Sipols, Alfred J.</au><au>Brief, Deborah J.</au><au>Ginter, Kari L.</au><au>Saghafi, Saman</au><au>Woods, Stephen C.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Neuropeptide Y paradoxically increases food intake yet causes conditioned flavor aversions</atitle><jtitle>Physiology & behavior</jtitle><addtitle>Physiol Behav</addtitle><date>1992-06-01</date><risdate>1992</risdate><volume>51</volume><issue>6</issue><spage>1257</spage><epage>1260</epage><pages>1257-1260</pages><issn>0031-9384</issn><eissn>1873-507X</eissn><abstract>Neuropeptides have been implicated in the short-term regulation of food intake and the long-term control of body weight. Previous studies have shown that central administration of neuropeptide Y (NPY), the most abundant of these peptides in the brain, produces robust increases of food intake. We now report that NPY, at doses that stimulate food intake when administered intraventricularly, also causes the formation of robust conditioned flavor aversions when given via the same cannula and at the same dose. This apparently paradoxical effect may be indicative of different populations of central NPY receptors having dissimilar effects on ingestive behaviors. The results also suggest that the use of conditioned aversions to investigate drug-induced malaise may not be appropriate when applied to ingestive behaviors.</abstract><cop>Cambridge</cop><cop>New York, NY</cop><pub>Elsevier Inc</pub><pmid>1641427</pmid><doi>10.1016/0031-9384(92)90317-U</doi><tpages>4</tpages></addata></record> |
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subjects | Animals Behavioral psychophysiology Biological and medical sciences Conditioned flavor aversion Conditioning, Operant - drug effects Eating - drug effects Food intake Fundamental and applied biological sciences. Psychology Injections, Intraventricular Long-Evans rats Male Neuropeptide Y Neuropeptide Y - pharmacology Neurotransmission and behavior Psychology. Psychoanalysis. Psychiatry Psychology. Psychophysiology Rats Taste - drug effects |
title | Neuropeptide Y paradoxically increases food intake yet causes conditioned flavor aversions |
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