Neuropeptide Y paradoxically increases food intake yet causes conditioned flavor aversions

Neuropeptides have been implicated in the short-term regulation of food intake and the long-term control of body weight. Previous studies have shown that central administration of neuropeptide Y (NPY), the most abundant of these peptides in the brain, produces robust increases of food intake. We now...

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Veröffentlicht in:Physiology & behavior 1992-06, Vol.51 (6), p.1257-1260
Hauptverfasser: Sipols, Alfred J., Brief, Deborah J., Ginter, Kari L., Saghafi, Saman, Woods, Stephen C.
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container_end_page 1260
container_issue 6
container_start_page 1257
container_title Physiology & behavior
container_volume 51
creator Sipols, Alfred J.
Brief, Deborah J.
Ginter, Kari L.
Saghafi, Saman
Woods, Stephen C.
description Neuropeptides have been implicated in the short-term regulation of food intake and the long-term control of body weight. Previous studies have shown that central administration of neuropeptide Y (NPY), the most abundant of these peptides in the brain, produces robust increases of food intake. We now report that NPY, at doses that stimulate food intake when administered intraventricularly, also causes the formation of robust conditioned flavor aversions when given via the same cannula and at the same dose. This apparently paradoxical effect may be indicative of different populations of central NPY receptors having dissimilar effects on ingestive behaviors. The results also suggest that the use of conditioned aversions to investigate drug-induced malaise may not be appropriate when applied to ingestive behaviors.
doi_str_mv 10.1016/0031-9384(92)90317-U
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source MEDLINE; Elsevier ScienceDirect Journals
subjects Animals
Behavioral psychophysiology
Biological and medical sciences
Conditioned flavor aversion
Conditioning, Operant - drug effects
Eating - drug effects
Food intake
Fundamental and applied biological sciences. Psychology
Injections, Intraventricular
Long-Evans rats
Male
Neuropeptide Y
Neuropeptide Y - pharmacology
Neurotransmission and behavior
Psychology. Psychoanalysis. Psychiatry
Psychology. Psychophysiology
Rats
Taste - drug effects
title Neuropeptide Y paradoxically increases food intake yet causes conditioned flavor aversions
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