The endothelin ETB receptor mediates both vasodilation and vasoconstriction in vivo
It has been suggested that the endothelin (ET) ETB receptor could mediate endothelium-dependent vasodilation to ET-1 or ET-3, but its in vivo role is still largely unknown. We used sarafotoxin S6C, a selective agonist of the ETB receptor, to study the in vivo effects of ETB stimulation. SRTX S6C ind...
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| Veröffentlicht in: | Biochemical and biophysical research communications 1992-07, Vol.186 (2), p.867-873 |
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| container_title | Biochemical and biophysical research communications |
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| creator | CLOZEL, M GRAY, G. A BREU, V LÖFFLER, B.-M OSTERWALDER, R |
| description | It has been suggested that the endothelin (ET) ETB receptor could mediate endothelium-dependent vasodilation to ET-1 or ET-3, but its in vivo role is still largely unknown. We used sarafotoxin S6C, a selective agonist of the ETB receptor, to study the in vivo effects of ETB stimulation. SRTX S6C induced a transient decrease in blood pressure, followed by a long-lasting pressor response accompanied by a marked renal and mesenteric vasoconstriction. No constriction was observed in isolated mesenteric arteries in vitro, indicating that the in vivo vasoconstrictor effect is most likely indirect. The pressor effect of SRTX S6C was not dependent on central stimulation of ETB receptors and was not mediated by catecholamines from the adrenal medulla, prostanoids or ET-1. |
| doi_str_mv | 10.1016/0006-291x(92)90826-7 |
| format | Article |
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The pressor effect of SRTX S6C was not dependent on central stimulation of ETB receptors and was not mediated by catecholamines from the adrenal medulla, prostanoids or ET-1.</description><identifier>ISSN: 0006-291X</identifier><identifier>EISSN: 1090-2104</identifier><identifier>DOI: 10.1016/0006-291x(92)90826-7</identifier><identifier>PMID: 1323294</identifier><identifier>CODEN: BBRCA9</identifier><language>eng</language><publisher>San Diego, CA: Elsevier</publisher><subject>Animals ; Biological and medical sciences ; Blood Pressure - drug effects ; Blood vessels and receptors ; Decerebrate State ; Endothelins - pharmacology ; Endothelium, Vascular - physiology ; Fundamental and applied biological sciences. 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A</creatorcontrib><creatorcontrib>BREU, V</creatorcontrib><creatorcontrib>LÖFFLER, B.-M</creatorcontrib><creatorcontrib>OSTERWALDER, R</creatorcontrib><title>The endothelin ETB receptor mediates both vasodilation and vasoconstriction in vivo</title><title>Biochemical and biophysical research communications</title><addtitle>Biochem Biophys Res Commun</addtitle><description>It has been suggested that the endothelin (ET) ETB receptor could mediate endothelium-dependent vasodilation to ET-1 or ET-3, but its in vivo role is still largely unknown. We used sarafotoxin S6C, a selective agonist of the ETB receptor, to study the in vivo effects of ETB stimulation. SRTX S6C induced a transient decrease in blood pressure, followed by a long-lasting pressor response accompanied by a marked renal and mesenteric vasoconstriction. No constriction was observed in isolated mesenteric arteries in vitro, indicating that the in vivo vasoconstrictor effect is most likely indirect. The pressor effect of SRTX S6C was not dependent on central stimulation of ETB receptors and was not mediated by catecholamines from the adrenal medulla, prostanoids or ET-1.</description><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Blood Pressure - drug effects</subject><subject>Blood vessels and receptors</subject><subject>Decerebrate State</subject><subject>Endothelins - pharmacology</subject><subject>Endothelium, Vascular - physiology</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Heart Rate - drug effects</subject><subject>In Vitro Techniques</subject><subject>Male</subject><subject>Mesenteric Arteries - drug effects</subject><subject>Mesenteric Arteries - physiology</subject><subject>Methoxamine - pharmacology</subject><subject>Muscle, Smooth, Vascular - drug effects</subject><subject>Muscle, Smooth, Vascular - physiology</subject><subject>Rats</subject><subject>Rats, Inbred Strains</subject><subject>Receptors, Cell Surface - drug effects</subject><subject>Receptors, Cell Surface - physiology</subject><subject>Receptors, Endothelin</subject><subject>Regional Blood Flow - drug effects</subject><subject>Renal Circulation - drug effects</subject><subject>Vasoconstriction - drug effects</subject><subject>Vasoconstrictor Agents - pharmacology</subject><subject>Vasodilation - drug effects</subject><subject>Vertebrates: cardiovascular system</subject><subject>Viper Venoms - pharmacology</subject><issn>0006-291X</issn><issn>1090-2104</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1992</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkEtLAzEUhYMotVb_gcIsRHQxmpukmclSS31AwYUV3IU0cwcj00lNpkX_velDXR2455wL5yPkFOg1UJA3lFKZMwVfl4pdKVoymRd7pA9U0ZwBFfuk_xt5OyRHMX5QCiCk6pEecMaZEn3yMn3HDNvKd-_YuDYbT--ygBYXnQ_ZHCtnOozZLNnZykRfucZ0zreZaavNwfo2dsHZzTH1V27lj8lBbZqIJzsdkNf78XT0mE-eH55Gt5Pccsm7fCjkzBai5lDKpEaWvKilrFgaB6bE0kKFQHEoy0KUFRpboRoqCdYWylLJB-Ri-3cR_OcSY6fnLlpsGtOiX0ZdcKBcCJaCYhu0wccYsNaL4OYmfGuges1Sr0HpNSitmN6wTO0BOdv9X84Siv_SFl7yz3e-idY0dTCtdfEvlvYJCYL_AIOWfGg</recordid><startdate>19920731</startdate><enddate>19920731</enddate><creator>CLOZEL, M</creator><creator>GRAY, G. A</creator><creator>BREU, V</creator><creator>LÖFFLER, B.-M</creator><creator>OSTERWALDER, R</creator><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19920731</creationdate><title>The endothelin ETB receptor mediates both vasodilation and vasoconstriction in vivo</title><author>CLOZEL, M ; GRAY, G. A ; BREU, V ; LÖFFLER, B.-M ; OSTERWALDER, R</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c363t-546bc74f3186c74a6837f66d20161a8e8c1de10e568748deacde95961cc79c063</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1992</creationdate><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Blood Pressure - drug effects</topic><topic>Blood vessels and receptors</topic><topic>Decerebrate State</topic><topic>Endothelins - pharmacology</topic><topic>Endothelium, Vascular - physiology</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Heart Rate - drug effects</topic><topic>In Vitro Techniques</topic><topic>Male</topic><topic>Mesenteric Arteries - drug effects</topic><topic>Mesenteric Arteries - physiology</topic><topic>Methoxamine - pharmacology</topic><topic>Muscle, Smooth, Vascular - drug effects</topic><topic>Muscle, Smooth, Vascular - physiology</topic><topic>Rats</topic><topic>Rats, Inbred Strains</topic><topic>Receptors, Cell Surface - drug effects</topic><topic>Receptors, Cell Surface - physiology</topic><topic>Receptors, Endothelin</topic><topic>Regional Blood Flow - drug effects</topic><topic>Renal Circulation - drug effects</topic><topic>Vasoconstriction - drug effects</topic><topic>Vasoconstrictor Agents - pharmacology</topic><topic>Vasodilation - drug effects</topic><topic>Vertebrates: cardiovascular system</topic><topic>Viper Venoms - pharmacology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>CLOZEL, M</creatorcontrib><creatorcontrib>GRAY, G. A</creatorcontrib><creatorcontrib>BREU, V</creatorcontrib><creatorcontrib>LÖFFLER, B.-M</creatorcontrib><creatorcontrib>OSTERWALDER, R</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Biochemical and biophysical research communications</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>CLOZEL, M</au><au>GRAY, G. A</au><au>BREU, V</au><au>LÖFFLER, B.-M</au><au>OSTERWALDER, R</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The endothelin ETB receptor mediates both vasodilation and vasoconstriction in vivo</atitle><jtitle>Biochemical and biophysical research communications</jtitle><addtitle>Biochem Biophys Res Commun</addtitle><date>1992-07-31</date><risdate>1992</risdate><volume>186</volume><issue>2</issue><spage>867</spage><epage>873</epage><pages>867-873</pages><issn>0006-291X</issn><eissn>1090-2104</eissn><coden>BBRCA9</coden><abstract>It has been suggested that the endothelin (ET) ETB receptor could mediate endothelium-dependent vasodilation to ET-1 or ET-3, but its in vivo role is still largely unknown. We used sarafotoxin S6C, a selective agonist of the ETB receptor, to study the in vivo effects of ETB stimulation. SRTX S6C induced a transient decrease in blood pressure, followed by a long-lasting pressor response accompanied by a marked renal and mesenteric vasoconstriction. No constriction was observed in isolated mesenteric arteries in vitro, indicating that the in vivo vasoconstrictor effect is most likely indirect. The pressor effect of SRTX S6C was not dependent on central stimulation of ETB receptors and was not mediated by catecholamines from the adrenal medulla, prostanoids or ET-1.</abstract><cop>San Diego, CA</cop><pub>Elsevier</pub><pmid>1323294</pmid><doi>10.1016/0006-291x(92)90826-7</doi><tpages>7</tpages></addata></record> |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Animals Biological and medical sciences Blood Pressure - drug effects Blood vessels and receptors Decerebrate State Endothelins - pharmacology Endothelium, Vascular - physiology Fundamental and applied biological sciences. Psychology Heart Rate - drug effects In Vitro Techniques Male Mesenteric Arteries - drug effects Mesenteric Arteries - physiology Methoxamine - pharmacology Muscle, Smooth, Vascular - drug effects Muscle, Smooth, Vascular - physiology Rats Rats, Inbred Strains Receptors, Cell Surface - drug effects Receptors, Cell Surface - physiology Receptors, Endothelin Regional Blood Flow - drug effects Renal Circulation - drug effects Vasoconstriction - drug effects Vasoconstrictor Agents - pharmacology Vasodilation - drug effects Vertebrates: cardiovascular system Viper Venoms - pharmacology |
| title | The endothelin ETB receptor mediates both vasodilation and vasoconstriction in vivo |
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