Effects of Blocking Platelet-Derived Growth Factor-Receptor Signaling in a Mouse Model of Experimental Prostate Cancer Bone Metastases

Background: Expression of platelet-derived growth factor (PDGF) and activation (by autophosphorylation) of its receptor (PDGF-R), a tyrosine kinase, are associated with the growth of metastatic prostate tumor cells in the bone parenchyma. The tyrosine kinase inhibitor STI571 blocks the PDGF signalin...

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Veröffentlicht in:	JNCI : Journal of the National Cancer Institute 2003-03, Vol.95 (6), p.458-470
Hauptverfasser:	Uehara, Hisanori, Kim, Sun Jin, Karashima, Takashi, Shepherd, David L., Fan, Dominic, Tsan, Rachel, Killion, Jerald J., Logothetis, Christopher, Mathew, Paul, Fidler, Isaiah J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Administration, Oral Animals Antineoplastic Agents - administration & dosage Antineoplastic Agents - pharmacology Antineoplastic Agents, Phytogenic - administration & dosage Antineoplastic Combined Chemotherapy Protocols - therapeutic use Apoptosis - drug effects Benzamides Blotting, Western Bone Neoplasms - blood supply Bone Neoplasms - diagnostic imaging Bone Neoplasms - drug therapy Bone Neoplasms - enzymology Bone Neoplasms - metabolism Bone Neoplasms - secondary Bones Cell Division - drug effects Disease Models, Animal Enzyme Inhibitors - administration & dosage Enzyme Inhibitors - pharmacology Fluorescent Antibody Technique Gene Expression Regulation, Neoplastic - drug effects Humans Imatinib Mesylate Immunohistochemistry In Situ Nick-End Labeling Male Medical research Mice Mice, Nude Microcirculation - drug effects Neoplasms, Experimental Paclitaxel - administration & dosage Phosphorylation - drug effects Piperazines - administration & dosage Piperazines - pharmacology Platelet-Derived Growth Factor - drug effects Platelet-Derived Growth Factor - metabolism Prostate cancer Prostatic Neoplasms - metabolism Prostatic Neoplasms - pathology Protein-Tyrosine Kinases - antagonists & inhibitors Pyrimidines - administration & dosage Pyrimidines - pharmacology Radiographic Image Enhancement Receptors, Platelet-Derived Growth Factor - drug effects Receptors, Platelet-Derived Growth Factor - metabolism Rodents Signal Transduction - drug effects Tumor Cells, Cultured Tumors
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