Cerebral function in posttraumatic stress disorder during verbal working memory updating: a positron emission tomography study
This study examined cerebral function in posttraumatic stress disorder (PTSD) during the updating of working memory to trauma-neutral, verbal information. Ten PTSD and matched control subjects completed a visuoverbal target detection task involving continuous updating (Variable target condition) or...
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| Veröffentlicht in: | Biological psychiatry (1969) 2003-03, Vol.53 (6), p.474-481 |
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| container_title | Biological psychiatry (1969) |
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| creator | Clark, C.Richard McFarlane, Alexander C Morris, Philip Weber, Darren L Sonkkilla, Cynon Shaw, Marnie Marcina, Jackie Tochon-Danguy, H.J Egan, Gary F |
| description | This study examined cerebral function in posttraumatic stress disorder (PTSD) during the updating of working memory to trauma-neutral, verbal information.
Ten PTSD and matched control subjects completed a visuoverbal target detection task involving continuous updating (Variable target condition) or no updating (Fixed target condition) of target identity, with updating activity estimated by condition comparison.
Normal updating activity using this paradigm involved bilateral activation of the dorsolateral prefrontal cortex (DLPFC) and inferior parietal lobe. The PTSD group lacked this activation in the left hemisphere and was significantly different from control subjects in this regard, but showed additional activation in the superior parietal lobe, bilaterally.
The pattern of parietal activation suggests a dependence on visuospatial coding for working memory representation of trauma-neutral, verbal information. Group differences in the relative involvement of the DLPFC indicate less dependence in PTSD on the executive role normally attributed to the left DLPFC for monitoring and manipulation of working memory content in posterior regions of the brain. |
| doi_str_mv | 10.1016/S0006-3223(02)01505-6 |
| format | Article |
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Ten PTSD and matched control subjects completed a visuoverbal target detection task involving continuous updating (Variable target condition) or no updating (Fixed target condition) of target identity, with updating activity estimated by condition comparison.
Normal updating activity using this paradigm involved bilateral activation of the dorsolateral prefrontal cortex (DLPFC) and inferior parietal lobe. The PTSD group lacked this activation in the left hemisphere and was significantly different from control subjects in this regard, but showed additional activation in the superior parietal lobe, bilaterally.
The pattern of parietal activation suggests a dependence on visuospatial coding for working memory representation of trauma-neutral, verbal information. Group differences in the relative involvement of the DLPFC indicate less dependence in PTSD on the executive role normally attributed to the left DLPFC for monitoring and manipulation of working memory content in posterior regions of the brain.</description><identifier>ISSN: 0006-3223</identifier><identifier>EISSN: 1873-2402</identifier><identifier>DOI: 10.1016/S0006-3223(02)01505-6</identifier><identifier>PMID: 12644352</identifier><identifier>CODEN: BIPCBF</identifier><language>eng</language><publisher>New York, NY: Elsevier Inc</publisher><subject>Adult and adolescent clinical studies ; Anxiety disorders. Neuroses ; Biological and medical sciences ; cortical networks ; Female ; frontal-parietal axis ; Humans ; Male ; Medical sciences ; Memory Disorders - diagnosis ; Memory Disorders - etiology ; Middle Aged ; Neuropsychological Tests ; Parietal Lobe - blood supply ; Parietal Lobe - metabolism ; Parietal Lobe - physiopathology ; positron emission tomography ; Post-traumatic stress disorder ; Posttraumatic stress disorder ; Prefrontal Cortex - blood supply ; Prefrontal Cortex - metabolism ; Prefrontal Cortex - physiopathology ; Psychology. Psychoanalysis. Psychiatry ; Psychopathology. Psychiatry ; Severity of Illness Index ; Stress Disorders, Post-Traumatic - metabolism ; Stress Disorders, Post-Traumatic - physiopathology ; Stress Disorders, Post-Traumatic - psychology ; Tomography, Emission-Computed ; Tropical medicine ; Visual Perception - physiology ; working memory</subject><ispartof>Biological psychiatry (1969), 2003-03, Vol.53 (6), p.474-481</ispartof><rights>2002 Society of Biological Psychiatry</rights><rights>2003 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c486t-339bb61c32423a3244537ca20916780fdbaf16a0f5ccf32fb8d112cbb96dc24e3</citedby><cites>FETCH-LOGICAL-c486t-339bb61c32423a3244537ca20916780fdbaf16a0f5ccf32fb8d112cbb96dc24e3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/S0006-3223(02)01505-6$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>315,781,785,3551,27929,27930,46000</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=14652699$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/12644352$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Clark, C.Richard</creatorcontrib><creatorcontrib>McFarlane, Alexander C</creatorcontrib><creatorcontrib>Morris, Philip</creatorcontrib><creatorcontrib>Weber, Darren L</creatorcontrib><creatorcontrib>Sonkkilla, Cynon</creatorcontrib><creatorcontrib>Shaw, Marnie</creatorcontrib><creatorcontrib>Marcina, Jackie</creatorcontrib><creatorcontrib>Tochon-Danguy, H.J</creatorcontrib><creatorcontrib>Egan, Gary F</creatorcontrib><title>Cerebral function in posttraumatic stress disorder during verbal working memory updating: a positron emission tomography study</title><title>Biological psychiatry (1969)</title><addtitle>Biol Psychiatry</addtitle><description>This study examined cerebral function in posttraumatic stress disorder (PTSD) during the updating of working memory to trauma-neutral, verbal information.
Ten PTSD and matched control subjects completed a visuoverbal target detection task involving continuous updating (Variable target condition) or no updating (Fixed target condition) of target identity, with updating activity estimated by condition comparison.
Normal updating activity using this paradigm involved bilateral activation of the dorsolateral prefrontal cortex (DLPFC) and inferior parietal lobe. The PTSD group lacked this activation in the left hemisphere and was significantly different from control subjects in this regard, but showed additional activation in the superior parietal lobe, bilaterally.
The pattern of parietal activation suggests a dependence on visuospatial coding for working memory representation of trauma-neutral, verbal information. Group differences in the relative involvement of the DLPFC indicate less dependence in PTSD on the executive role normally attributed to the left DLPFC for monitoring and manipulation of working memory content in posterior regions of the brain.</description><subject>Adult and adolescent clinical studies</subject><subject>Anxiety disorders. Neuroses</subject><subject>Biological and medical sciences</subject><subject>cortical networks</subject><subject>Female</subject><subject>frontal-parietal axis</subject><subject>Humans</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Memory Disorders - diagnosis</subject><subject>Memory Disorders - etiology</subject><subject>Middle Aged</subject><subject>Neuropsychological Tests</subject><subject>Parietal Lobe - blood supply</subject><subject>Parietal Lobe - metabolism</subject><subject>Parietal Lobe - physiopathology</subject><subject>positron emission tomography</subject><subject>Post-traumatic stress disorder</subject><subject>Posttraumatic stress disorder</subject><subject>Prefrontal Cortex - blood supply</subject><subject>Prefrontal Cortex - metabolism</subject><subject>Prefrontal Cortex - physiopathology</subject><subject>Psychology. Psychoanalysis. Psychiatry</subject><subject>Psychopathology. Psychiatry</subject><subject>Severity of Illness Index</subject><subject>Stress Disorders, Post-Traumatic - metabolism</subject><subject>Stress Disorders, Post-Traumatic - physiopathology</subject><subject>Stress Disorders, Post-Traumatic - psychology</subject><subject>Tomography, Emission-Computed</subject><subject>Tropical medicine</subject><subject>Visual Perception - physiology</subject><subject>working memory</subject><issn>0006-3223</issn><issn>1873-2402</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2003</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkE1v1DAQhi1ERZfCTwDlQgWHgL_ibLigasVHpUocgLPl2OPFkMRh7BTthd-O013RIxePRnre16OHkGeMvmaUqTdfKKWqFpyLl5S_oqyhTa0ekA3btqLmkvKHZPMPOSePU_pR1pZz9oicM66kFA3fkD87QOjRDJVfJptDnKowVXNMOaNZRpODrVJGSKlyIUV0gJVbMEz76hawL7nfEX-u6whjxEO1zK6Epv3byqw1IWOphDGktHbnOMY9mvn7obQu7vCEnHkzJHh6mhfk24f3X3ef6pvPH693Vze1lVuVayG6vlfMCi65MOWVjWit4bRjqt1S73rjmTLUN9Z6wX2_dYxx2_edcpZLEBfk8tg7Y_y1QMq6XGRhGMwEcUm6FYxy2cgCNkfQYkwJwesZw2jwoBnVq3h9J16vVjXl-k68ViX3_PTB0o_g7lMn0wV4cQJMsmbwaCYb0j0nVcNV1xXu3ZGDouM2AOpkA0wWXECwWbsY_nPKX-uwor4</recordid><startdate>20030315</startdate><enddate>20030315</enddate><creator>Clark, C.Richard</creator><creator>McFarlane, Alexander C</creator><creator>Morris, Philip</creator><creator>Weber, Darren L</creator><creator>Sonkkilla, Cynon</creator><creator>Shaw, Marnie</creator><creator>Marcina, Jackie</creator><creator>Tochon-Danguy, H.J</creator><creator>Egan, Gary F</creator><general>Elsevier Inc</general><general>Elsevier Science</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20030315</creationdate><title>Cerebral function in posttraumatic stress disorder during verbal working memory updating: a positron emission tomography study</title><author>Clark, C.Richard ; McFarlane, Alexander C ; Morris, Philip ; Weber, Darren L ; Sonkkilla, Cynon ; Shaw, Marnie ; Marcina, Jackie ; Tochon-Danguy, H.J ; Egan, Gary F</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c486t-339bb61c32423a3244537ca20916780fdbaf16a0f5ccf32fb8d112cbb96dc24e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2003</creationdate><topic>Adult and adolescent clinical studies</topic><topic>Anxiety disorders. Neuroses</topic><topic>Biological and medical sciences</topic><topic>cortical networks</topic><topic>Female</topic><topic>frontal-parietal axis</topic><topic>Humans</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Memory Disorders - diagnosis</topic><topic>Memory Disorders - etiology</topic><topic>Middle Aged</topic><topic>Neuropsychological Tests</topic><topic>Parietal Lobe - blood supply</topic><topic>Parietal Lobe - metabolism</topic><topic>Parietal Lobe - physiopathology</topic><topic>positron emission tomography</topic><topic>Post-traumatic stress disorder</topic><topic>Posttraumatic stress disorder</topic><topic>Prefrontal Cortex - blood supply</topic><topic>Prefrontal Cortex - metabolism</topic><topic>Prefrontal Cortex - physiopathology</topic><topic>Psychology. Psychoanalysis. Psychiatry</topic><topic>Psychopathology. Psychiatry</topic><topic>Severity of Illness Index</topic><topic>Stress Disorders, Post-Traumatic - metabolism</topic><topic>Stress Disorders, Post-Traumatic - physiopathology</topic><topic>Stress Disorders, Post-Traumatic - psychology</topic><topic>Tomography, Emission-Computed</topic><topic>Tropical medicine</topic><topic>Visual Perception - physiology</topic><topic>working memory</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Clark, C.Richard</creatorcontrib><creatorcontrib>McFarlane, Alexander C</creatorcontrib><creatorcontrib>Morris, Philip</creatorcontrib><creatorcontrib>Weber, Darren L</creatorcontrib><creatorcontrib>Sonkkilla, Cynon</creatorcontrib><creatorcontrib>Shaw, Marnie</creatorcontrib><creatorcontrib>Marcina, Jackie</creatorcontrib><creatorcontrib>Tochon-Danguy, H.J</creatorcontrib><creatorcontrib>Egan, Gary F</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Biological psychiatry (1969)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Clark, C.Richard</au><au>McFarlane, Alexander C</au><au>Morris, Philip</au><au>Weber, Darren L</au><au>Sonkkilla, Cynon</au><au>Shaw, Marnie</au><au>Marcina, Jackie</au><au>Tochon-Danguy, H.J</au><au>Egan, Gary F</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Cerebral function in posttraumatic stress disorder during verbal working memory updating: a positron emission tomography study</atitle><jtitle>Biological psychiatry (1969)</jtitle><addtitle>Biol Psychiatry</addtitle><date>2003-03-15</date><risdate>2003</risdate><volume>53</volume><issue>6</issue><spage>474</spage><epage>481</epage><pages>474-481</pages><issn>0006-3223</issn><eissn>1873-2402</eissn><coden>BIPCBF</coden><abstract>This study examined cerebral function in posttraumatic stress disorder (PTSD) during the updating of working memory to trauma-neutral, verbal information.
Ten PTSD and matched control subjects completed a visuoverbal target detection task involving continuous updating (Variable target condition) or no updating (Fixed target condition) of target identity, with updating activity estimated by condition comparison.
Normal updating activity using this paradigm involved bilateral activation of the dorsolateral prefrontal cortex (DLPFC) and inferior parietal lobe. The PTSD group lacked this activation in the left hemisphere and was significantly different from control subjects in this regard, but showed additional activation in the superior parietal lobe, bilaterally.
The pattern of parietal activation suggests a dependence on visuospatial coding for working memory representation of trauma-neutral, verbal information. Group differences in the relative involvement of the DLPFC indicate less dependence in PTSD on the executive role normally attributed to the left DLPFC for monitoring and manipulation of working memory content in posterior regions of the brain.</abstract><cop>New York, NY</cop><pub>Elsevier Inc</pub><pmid>12644352</pmid><doi>10.1016/S0006-3223(02)01505-6</doi><tpages>8</tpages></addata></record> |
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| subjects | Adult and adolescent clinical studies Anxiety disorders. Neuroses Biological and medical sciences cortical networks Female frontal-parietal axis Humans Male Medical sciences Memory Disorders - diagnosis Memory Disorders - etiology Middle Aged Neuropsychological Tests Parietal Lobe - blood supply Parietal Lobe - metabolism Parietal Lobe - physiopathology positron emission tomography Post-traumatic stress disorder Posttraumatic stress disorder Prefrontal Cortex - blood supply Prefrontal Cortex - metabolism Prefrontal Cortex - physiopathology Psychology. Psychoanalysis. Psychiatry Psychopathology. Psychiatry Severity of Illness Index Stress Disorders, Post-Traumatic - metabolism Stress Disorders, Post-Traumatic - physiopathology Stress Disorders, Post-Traumatic - psychology Tomography, Emission-Computed Tropical medicine Visual Perception - physiology working memory |
| title | Cerebral function in posttraumatic stress disorder during verbal working memory updating: a positron emission tomography study |
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