GASTRODUODENAL DYSFUNCTION AS A CAUSE OF GASTRIC BACTERIAL OVERGROWTH IN PATIENTS UNDERGOING MECHANICAL VENTILATION OF THE LUNGS
We have studied 15 patients undergoing mechanical ventilation of the lungs for evidence of a relationship between gastroduodenal dysfunction and gastric bacterial overgrowth. Duodenal reflux was detected by quantitative measurement of conjugated bilirubin in gastric aspirate specimens. The pH and ba...
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| Veröffentlicht in: | British journal of anaesthesia : BJA 1992-05, Vol.68 (5), p.499-502 |
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| container_title | British journal of anaesthesia : BJA |
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| creator | INGLIS, T.J.J. SPROAT, L.J. SHERRATT, M.J. HAWKEY, P.M. GIBSON, J.S. SHAH, M.V. |
| description | We have studied 15 patients undergoing mechanical ventilation of the lungs for evidence of a relationship between gastroduodenal dysfunction and gastric bacterial overgrowth. Duodenal reflux was detected by quantitative measurement of conjugated bilirubin in gastric aspirate specimens. The pH and bacterial content of these specimens were analysed. A minority of specimens with pH < 3.5 contained measurable numbers of viable bacteria. The total bacterial count and the count of Gram negative bacteria correlated significantly with specimen pH in both cases (P < 0.001, in both). In the 72 specimens of gastric aspirate with pH > 3.5, the presence of Gram negative bacteria was associated significantly with detectable bilirubin (P < 0.001). The total bacterial count was greater also in specimens containing bilirubin (P = 0.009). These results suggest that gastroduodenal dysfunction may promote gastric bacterial overgrowth, contributing to the development of ventilator-associated pneumonia. |
| doi_str_mv | 10.1093/bja/68.5.499 |
| format | Article |
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Duodenal reflux was detected by quantitative measurement of conjugated bilirubin in gastric aspirate specimens. The pH and bacterial content of these specimens were analysed. A minority of specimens with pH < 3.5 contained measurable numbers of viable bacteria. The total bacterial count and the count of Gram negative bacteria correlated significantly with specimen pH in both cases (P < 0.001, in both). In the 72 specimens of gastric aspirate with pH > 3.5, the presence of Gram negative bacteria was associated significantly with detectable bilirubin (P < 0.001). The total bacterial count was greater also in specimens containing bilirubin (P = 0.009). These results suggest that gastroduodenal dysfunction may promote gastric bacterial overgrowth, contributing to the development of ventilator-associated pneumonia.</description><identifier>ISSN: 0007-0912</identifier><identifier>EISSN: 1471-6771</identifier><identifier>DOI: 10.1093/bja/68.5.499</identifier><identifier>PMID: 1642939</identifier><identifier>CODEN: BJANAD</identifier><language>eng</language><publisher>Oxford: Elsevier Ltd</publisher><subject>Adult ; Aged ; Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy ; Bacterial Infections - etiology ; Bilirubin - analysis ; Biological and medical sciences ; Colony Count, Microbial ; Duodenogastric Reflux - complications ; Emergency and intensive respiratory care ; Female ; Gastric Acidity Determination ; Gastrointestinal tract: gastric bacterial overgrowth ; Humans ; Hydrogen-Ion Concentration ; Intensive care medicine ; Intensive care: mechanical ventilation ; Male ; Medical sciences ; Middle Aged ; Pneumonia - etiology ; Respiration, Artificial - adverse effects ; Stomach Diseases - microbiology</subject><ispartof>British journal of anaesthesia : BJA, 1992-05, Vol.68 (5), p.499-502</ispartof><rights>1992</rights><rights>1992 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c438t-c20d92fc7937d6bcc3caefc19dac678b4cd051c32e74d9fba74ae51b05dc50103</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=5250264$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/1642939$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>INGLIS, T.J.J.</creatorcontrib><creatorcontrib>SPROAT, L.J.</creatorcontrib><creatorcontrib>SHERRATT, M.J.</creatorcontrib><creatorcontrib>HAWKEY, P.M.</creatorcontrib><creatorcontrib>GIBSON, J.S.</creatorcontrib><creatorcontrib>SHAH, M.V.</creatorcontrib><title>GASTRODUODENAL DYSFUNCTION AS A CAUSE OF GASTRIC BACTERIAL OVERGROWTH IN PATIENTS UNDERGOING MECHANICAL VENTILATION OF THE LUNGS</title><title>British journal of anaesthesia : BJA</title><addtitle>Br J Anaesth</addtitle><description>We have studied 15 patients undergoing mechanical ventilation of the lungs for evidence of a relationship between gastroduodenal dysfunction and gastric bacterial overgrowth. Duodenal reflux was detected by quantitative measurement of conjugated bilirubin in gastric aspirate specimens. The pH and bacterial content of these specimens were analysed. A minority of specimens with pH < 3.5 contained measurable numbers of viable bacteria. The total bacterial count and the count of Gram negative bacteria correlated significantly with specimen pH in both cases (P < 0.001, in both). In the 72 specimens of gastric aspirate with pH > 3.5, the presence of Gram negative bacteria was associated significantly with detectable bilirubin (P < 0.001). The total bacterial count was greater also in specimens containing bilirubin (P = 0.009). These results suggest that gastroduodenal dysfunction may promote gastric bacterial overgrowth, contributing to the development of ventilator-associated pneumonia.</description><subject>Adult</subject><subject>Aged</subject><subject>Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy</subject><subject>Bacterial Infections - etiology</subject><subject>Bilirubin - analysis</subject><subject>Biological and medical sciences</subject><subject>Colony Count, Microbial</subject><subject>Duodenogastric Reflux - complications</subject><subject>Emergency and intensive respiratory care</subject><subject>Female</subject><subject>Gastric Acidity Determination</subject><subject>Gastrointestinal tract: gastric bacterial overgrowth</subject><subject>Humans</subject><subject>Hydrogen-Ion Concentration</subject><subject>Intensive care medicine</subject><subject>Intensive care: mechanical ventilation</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Pneumonia - etiology</subject><subject>Respiration, Artificial - adverse effects</subject><subject>Stomach Diseases - microbiology</subject><issn>0007-0912</issn><issn>1471-6771</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1992</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpt0M1v0zAABXALMY2yceOK5APiRDrbieP4GNI0CYQENck6uFiO40gZ_Rhxi-DGnz5vqcZlJ0t-Pz9ZD4C3GM0x4u5Veyuv_GBO5x7nL8AMeww7PmP4JZghhJiDOCavwGtjbhHCjHB6Ds6x7xHu8hn4l4RVvSoXTbmIizCHi-_VsimiOisLGFYwhFHYVDEsl_ARZhH8FEZ1vMqsLa_jVbIq13UKswJ-C-ssLuoKNsXC3pdZkcCvcZSGRRZZfG2zLA8fi21bncYwb4qkugRnvdwY_eZ0XoBmGddR6uRl8vDQUZ4bHBxFUMdJrxh3Wee3SrlK6l5h3knls6D1VIcoVi7RzOt430rmSU1xi2inKMLIvQAfpt67cf_rqM1BbAej9GYjd3p_NIK5GBHicQs_TlCNe2NG3Yu7cdjK8a_ASDwMLuzgwg8EFXZwy9-deo_tVnf_8bSwzd-fcmmU3PSj3KnBPDFKKCK-Z5kzscEc9J-nWI4_hc9cRkV680PcrD8HX9aYitx6f_LabvZ70KMwatA7pbth1Ooguv3w_H_vAQrBoLY</recordid><startdate>19920501</startdate><enddate>19920501</enddate><creator>INGLIS, T.J.J.</creator><creator>SPROAT, L.J.</creator><creator>SHERRATT, M.J.</creator><creator>HAWKEY, P.M.</creator><creator>GIBSON, J.S.</creator><creator>SHAH, M.V.</creator><general>Elsevier Ltd</general><general>Oxford University Press</general><scope>6I.</scope><scope>AAFTH</scope><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19920501</creationdate><title>GASTRODUODENAL DYSFUNCTION AS A CAUSE OF GASTRIC BACTERIAL OVERGROWTH IN PATIENTS UNDERGOING MECHANICAL VENTILATION OF THE LUNGS</title><author>INGLIS, T.J.J. ; SPROAT, L.J. ; SHERRATT, M.J. ; HAWKEY, P.M. ; GIBSON, J.S. ; SHAH, M.V.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c438t-c20d92fc7937d6bcc3caefc19dac678b4cd051c32e74d9fba74ae51b05dc50103</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1992</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy</topic><topic>Bacterial Infections - etiology</topic><topic>Bilirubin - analysis</topic><topic>Biological and medical sciences</topic><topic>Colony Count, Microbial</topic><topic>Duodenogastric Reflux - complications</topic><topic>Emergency and intensive respiratory care</topic><topic>Female</topic><topic>Gastric Acidity Determination</topic><topic>Gastrointestinal tract: gastric bacterial overgrowth</topic><topic>Humans</topic><topic>Hydrogen-Ion Concentration</topic><topic>Intensive care medicine</topic><topic>Intensive care: mechanical ventilation</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Pneumonia - etiology</topic><topic>Respiration, Artificial - adverse effects</topic><topic>Stomach Diseases - microbiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>INGLIS, T.J.J.</creatorcontrib><creatorcontrib>SPROAT, L.J.</creatorcontrib><creatorcontrib>SHERRATT, M.J.</creatorcontrib><creatorcontrib>HAWKEY, P.M.</creatorcontrib><creatorcontrib>GIBSON, J.S.</creatorcontrib><creatorcontrib>SHAH, M.V.</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>British journal of anaesthesia : BJA</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>INGLIS, T.J.J.</au><au>SPROAT, L.J.</au><au>SHERRATT, M.J.</au><au>HAWKEY, P.M.</au><au>GIBSON, J.S.</au><au>SHAH, M.V.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>GASTRODUODENAL DYSFUNCTION AS A CAUSE OF GASTRIC BACTERIAL OVERGROWTH IN PATIENTS UNDERGOING MECHANICAL VENTILATION OF THE LUNGS</atitle><jtitle>British journal of anaesthesia : BJA</jtitle><addtitle>Br J Anaesth</addtitle><date>1992-05-01</date><risdate>1992</risdate><volume>68</volume><issue>5</issue><spage>499</spage><epage>502</epage><pages>499-502</pages><issn>0007-0912</issn><eissn>1471-6771</eissn><coden>BJANAD</coden><abstract>We have studied 15 patients undergoing mechanical ventilation of the lungs for evidence of a relationship between gastroduodenal dysfunction and gastric bacterial overgrowth. Duodenal reflux was detected by quantitative measurement of conjugated bilirubin in gastric aspirate specimens. The pH and bacterial content of these specimens were analysed. A minority of specimens with pH < 3.5 contained measurable numbers of viable bacteria. The total bacterial count and the count of Gram negative bacteria correlated significantly with specimen pH in both cases (P < 0.001, in both). In the 72 specimens of gastric aspirate with pH > 3.5, the presence of Gram negative bacteria was associated significantly with detectable bilirubin (P < 0.001). The total bacterial count was greater also in specimens containing bilirubin (P = 0.009). These results suggest that gastroduodenal dysfunction may promote gastric bacterial overgrowth, contributing to the development of ventilator-associated pneumonia.</abstract><cop>Oxford</cop><pub>Elsevier Ltd</pub><pmid>1642939</pmid><doi>10.1093/bja/68.5.499</doi><tpages>4</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Adult Aged Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy Bacterial Infections - etiology Bilirubin - analysis Biological and medical sciences Colony Count, Microbial Duodenogastric Reflux - complications Emergency and intensive respiratory care Female Gastric Acidity Determination Gastrointestinal tract: gastric bacterial overgrowth Humans Hydrogen-Ion Concentration Intensive care medicine Intensive care: mechanical ventilation Male Medical sciences Middle Aged Pneumonia - etiology Respiration, Artificial - adverse effects Stomach Diseases - microbiology |
| title | GASTRODUODENAL DYSFUNCTION AS A CAUSE OF GASTRIC BACTERIAL OVERGROWTH IN PATIENTS UNDERGOING MECHANICAL VENTILATION OF THE LUNGS |
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