Homologous desensitization of calcitonin gene-related peptide response in rat glomerular mesangial cells in culture

Addition of calcitonin gene-related peptide (CGRP) to rat glomerular mesangial cells in culture resulted in an increase in cyclic adenosine monophosphate (cAMP) accumulation in a concentration-dependent fashion with an EC50 of approximately 3 nM. Inclusion of CGRP8-37, a CGRP1 selective antagonist s...

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Veröffentlicht in:	Molecular and cellular biochemistry 1992-07, Vol.113 (1), p.17-23
Hauptverfasser:	AIYAR, N, GRIFFIN, E, ALBRIGHTSON-WINSLOW, C, FEUERSTEIN, G, NAMBI, P
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Calcitonin Gene-Related Peptide - physiology Cell physiology Cells, Cultured Cyclic AMP - metabolism Fundamental and applied biological sciences. Psychology Glomerular Mesangium - metabolism Molecular and cellular biology Rats Rats, Inbred Strains Receptors, Calcitonin Receptors, Cell Surface - metabolism Responses to growth factors, tumor promotors, other factors Tachyphylaxis
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