Normal B‐1 cell development but defective BCR signaling in LCK–/– mice

Mature B cells are grouped into two major subsets, B‐1 and B‐2, believed to derive from separate lineages. We have recently shown that B‐1 cells, which are characterized by CD5 surface expression, specifically exhibit significant levels of the tyrosine kinase Lck in man. Here we show that also in mi...

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