Paraventricular Nucleus Administration of Calcitonin Gene-Related Peptide Inhibits Food Intake and Stimulates the Hypothalamo-Pituitary-Adrenal Axis

Calcitonin gene-related protein (CGRP) inhibits food intake and stimulates the hypothalamo-pituitary-adrenal (HPA) axis after intracerebroventricular injection in rats. However, the hypothalamic site and mechanism of action are unknown. We investigated the effects of intraparaventricular nucleus adm...

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Veröffentlicht in:	Endocrinology (Philadelphia) 2003-04, Vol.144 (4), p.1420-1425
Hauptverfasser:	Dhillo, Waljit S, Small, Caroline J, Jethwa, Preeti H, Russell, Sabina H, Gardiner, James V, Bewick, Gavin A, Seth, Asha, Murphy, Kevin G, Ghatei, Mohammad A, Bloom, Stephen R
Format:	Artikel
Sprache:	eng
Schlagworte:	Adrenocorticotropic Hormone - blood Agouti-related protein Amphetamines Animals Argipressin Biological and medical sciences Calcitonin Calcitonin gene-related peptide Calcitonin Gene-Related Peptide - genetics Calcitonin Gene-Related Peptide - pharmacology Catheterization Cocaine Corticosterone - blood Corticotropin-releasing hormone Dietary restrictions Eating - drug effects Explants Fasting - physiology Food Food intake Fundamental and applied biological sciences. Psychology Gene Expression - physiology Hypothalamic-pituitary-adrenal axis Hypothalamo-Hypophyseal System - drug effects Hypothalamo-Hypophyseal System - physiology Hypothalamus In Vitro Techniques Injection Intracerebroventricular administration Male Microinjections Neuropeptide Y Neuropeptides - metabolism Paraventricular Hypothalamic Nucleus - drug effects Paraventricular Hypothalamic Nucleus - physiology Paraventricular nucleus Peptide Fragments - genetics Peptide Fragments - pharmacology Pituitary Pituitary-Adrenal System - drug effects Pituitary-Adrenal System - physiology Proteins Rats Rats, Wistar RNA, Messenger - analysis Vasopressin
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