Participation in Normal Immune Responses of a Metastasis-Inducing Splice Variant of CD44
A variant of the glycoprotein CD44 (CD44v) that shares sequences with variants causally involved in metastasis formation is transiently expressed on B and T lymphocytes and macrophages after antigenic stimulation and in the postnatal period. Antibodies to the variant hinder in vivo activation of bot...
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| Veröffentlicht in: | Science (American Association for the Advancement of Science) 1992-07, Vol.257 (5070), p.682-685 |
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| container_issue | 5070 |
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| container_title | Science (American Association for the Advancement of Science) |
| container_volume | 257 |
| creator | Arch, Robert Wirth, Karin Hofmann, Martin Ponta, Helmut Matzku, Siegfried Herrlich, Peter Zöller, Margot |
| description | A variant of the glycoprotein CD44 (CD44v) that shares sequences with variants causally involved in metastasis formation is transiently expressed on B and T lymphocytes and macrophages after antigenic stimulation and in the postnatal period. Antibodies to the variant hinder in vivo activation of both B and T cells. The observation that a protein domain that is expressed on CD44 and required for the lymphatic spread of tumor cells can catalyze an essential step in the process of lymphocyte activation supports the idea that metastasizing tumor cells mimic lymphocyte behavior. |
| doi_str_mv | 10.1126/science.1496383 |
| format | Article |
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Antibodies to the variant hinder in vivo activation of both B and T cells. The observation that a protein domain that is expressed on CD44 and required for the lymphatic spread of tumor cells can catalyze an essential step in the process of lymphocyte activation supports the idea that metastasizing tumor cells mimic lymphocyte behavior.</description><identifier>ISSN: 0036-8075</identifier><identifier>EISSN: 1095-9203</identifier><identifier>DOI: 10.1126/science.1496383</identifier><identifier>PMID: 1496383</identifier><language>eng</language><publisher>United States: American Society for the Advancement of Science</publisher><subject>Animals ; Antibodies ; Antibodies, Monoclonal ; Antigen presenting cells ; B lymphocytes ; B-Lymphocytes - immunology ; Base Sequence ; Blotting, Northern ; Bone marrow cells ; Cancer metastasis ; Cell adhesion molecules ; DNA - chemistry ; Epitopes ; Exons ; Genetic aspects ; Genetic Variation ; Immune response ; Lymph nodes ; Lymphocyte Activation ; Lymphocytes ; Metastasis ; Molecular Sequence Data ; Neoplasm Metastasis - immunology ; Rats ; Receptors, Lymphocyte Homing - analysis ; Receptors, Lymphocyte Homing - genetics ; Receptors, Lymphocyte Homing - immunology ; T lymphocytes ; T-Lymphocytes - immunology ; Tumor Cells, Cultured ; Tumors</subject><ispartof>Science (American Association for the Advancement of Science), 1992-07, Vol.257 (5070), p.682-685</ispartof><rights>Copyright 1992 American Association for the Advancement of Science</rights><rights>COPYRIGHT 1992 American Association for the Advancement of Science</rights><rights>COPYRIGHT 1992 American Association for the Advancement of Science</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c653t-f5554f3a32b7e7449c14de3a909deacb1bf7839b5cf72e541315fcc0208feafc3</citedby><cites>FETCH-LOGICAL-c653t-f5554f3a32b7e7449c14de3a909deacb1bf7839b5cf72e541315fcc0208feafc3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/2877491$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/2877491$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>314,776,780,799,2870,2871,27903,27904,57996,58229</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/1496383$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Arch, Robert</creatorcontrib><creatorcontrib>Wirth, Karin</creatorcontrib><creatorcontrib>Hofmann, Martin</creatorcontrib><creatorcontrib>Ponta, Helmut</creatorcontrib><creatorcontrib>Matzku, Siegfried</creatorcontrib><creatorcontrib>Herrlich, Peter</creatorcontrib><creatorcontrib>Zöller, Margot</creatorcontrib><title>Participation in Normal Immune Responses of a Metastasis-Inducing Splice Variant of CD44</title><title>Science (American Association for the Advancement of Science)</title><addtitle>Science</addtitle><description>A variant of the glycoprotein CD44 (CD44v) that shares sequences with variants causally involved in metastasis formation is transiently expressed on B and T lymphocytes and macrophages after antigenic stimulation and in the postnatal period. Antibodies to the variant hinder in vivo activation of both B and T cells. The observation that a protein domain that is expressed on CD44 and required for the lymphatic spread of tumor cells can catalyze an essential step in the process of lymphocyte activation supports the idea that metastasizing tumor cells mimic lymphocyte behavior.</description><subject>Animals</subject><subject>Antibodies</subject><subject>Antibodies, Monoclonal</subject><subject>Antigen presenting cells</subject><subject>B lymphocytes</subject><subject>B-Lymphocytes - immunology</subject><subject>Base Sequence</subject><subject>Blotting, Northern</subject><subject>Bone marrow cells</subject><subject>Cancer metastasis</subject><subject>Cell adhesion molecules</subject><subject>DNA - chemistry</subject><subject>Epitopes</subject><subject>Exons</subject><subject>Genetic aspects</subject><subject>Genetic Variation</subject><subject>Immune response</subject><subject>Lymph nodes</subject><subject>Lymphocyte Activation</subject><subject>Lymphocytes</subject><subject>Metastasis</subject><subject>Molecular Sequence Data</subject><subject>Neoplasm Metastasis - immunology</subject><subject>Rats</subject><subject>Receptors, Lymphocyte Homing - analysis</subject><subject>Receptors, Lymphocyte Homing - genetics</subject><subject>Receptors, Lymphocyte Homing - immunology</subject><subject>T lymphocytes</subject><subject>T-Lymphocytes - immunology</subject><subject>Tumor Cells, Cultured</subject><subject>Tumors</subject><issn>0036-8075</issn><issn>1095-9203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1992</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqN0s9rFDEUB_AgSl2rZy8KcxIPnTY_JvPjWFddF9auWC3eQibzsqTMJGOSAf3vTdmhsrCHJYFAvp-8HN5D6DXBl4TQ8iooA1bBJSmaktXsCVoQ3PC8oZg9RQuMWZnXuOLP0YsQ7jFOWcPO0NnMF-jXN-mjUWaU0TibGZvdOD_IPlsPw2Qh-w5hdDZAyJzOZPYVogxpm5CvbTcpY3fZ7dgbBdmd9Eba-OCWH4viJXqmZR_g1Xyeo5-fP_1Yfsk329V6eb3JVclZzDXnvNBMMtpWUBVFo0jRAZMNbjqQqiWtrmrWtFzpigIvCCNcK4UprjVIrdg5erevO3r3e4IQxWCCgr6XFtwURMVwU1FKE7zYw53sQRirXfRS7cCCl72zoE26viaUl4TWVeL5EZ5WB4NRx_z7A59IhD9xJ6cQxPr25mS6vTuZflidSuvV5oBeHKPK9T3sQKT-LLcH_GrPlXcheNBi9GaQ_q8gWDxMoZinUMxjlV68nZsytQN0__1j_maf34fo_GOcPquKhrB_rlfeHw</recordid><startdate>19920731</startdate><enddate>19920731</enddate><creator>Arch, Robert</creator><creator>Wirth, Karin</creator><creator>Hofmann, Martin</creator><creator>Ponta, Helmut</creator><creator>Matzku, Siegfried</creator><creator>Herrlich, Peter</creator><creator>Zöller, Margot</creator><general>American Society for the Advancement of Science</general><general>American Association for the Advancement of Science</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>8GL</scope><scope>IBG</scope><scope>IOV</scope><scope>ISN</scope><scope>7X8</scope></search><sort><creationdate>19920731</creationdate><title>Participation in Normal Immune Responses of a Metastasis-Inducing Splice Variant of CD44</title><author>Arch, Robert ; Wirth, Karin ; Hofmann, Martin ; Ponta, Helmut ; Matzku, Siegfried ; Herrlich, Peter ; Zöller, Margot</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c653t-f5554f3a32b7e7449c14de3a909deacb1bf7839b5cf72e541315fcc0208feafc3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1992</creationdate><topic>Animals</topic><topic>Antibodies</topic><topic>Antibodies, Monoclonal</topic><topic>Antigen presenting cells</topic><topic>B lymphocytes</topic><topic>B-Lymphocytes - immunology</topic><topic>Base Sequence</topic><topic>Blotting, Northern</topic><topic>Bone marrow cells</topic><topic>Cancer metastasis</topic><topic>Cell adhesion molecules</topic><topic>DNA - chemistry</topic><topic>Epitopes</topic><topic>Exons</topic><topic>Genetic aspects</topic><topic>Genetic Variation</topic><topic>Immune response</topic><topic>Lymph nodes</topic><topic>Lymphocyte Activation</topic><topic>Lymphocytes</topic><topic>Metastasis</topic><topic>Molecular Sequence Data</topic><topic>Neoplasm Metastasis - immunology</topic><topic>Rats</topic><topic>Receptors, Lymphocyte Homing - analysis</topic><topic>Receptors, Lymphocyte Homing - genetics</topic><topic>Receptors, Lymphocyte Homing - immunology</topic><topic>T lymphocytes</topic><topic>T-Lymphocytes - immunology</topic><topic>Tumor Cells, Cultured</topic><topic>Tumors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Arch, Robert</creatorcontrib><creatorcontrib>Wirth, Karin</creatorcontrib><creatorcontrib>Hofmann, Martin</creatorcontrib><creatorcontrib>Ponta, Helmut</creatorcontrib><creatorcontrib>Matzku, Siegfried</creatorcontrib><creatorcontrib>Herrlich, Peter</creatorcontrib><creatorcontrib>Zöller, Margot</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Gale In Context: High School</collection><collection>Gale In Context: Biography</collection><collection>Gale In Context: Opposing Viewpoints</collection><collection>Gale In Context: Canada</collection><collection>MEDLINE - Academic</collection><jtitle>Science (American Association for the Advancement of Science)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Arch, Robert</au><au>Wirth, Karin</au><au>Hofmann, Martin</au><au>Ponta, Helmut</au><au>Matzku, Siegfried</au><au>Herrlich, Peter</au><au>Zöller, Margot</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Participation in Normal Immune Responses of a Metastasis-Inducing Splice Variant of CD44</atitle><jtitle>Science (American Association for the Advancement of Science)</jtitle><addtitle>Science</addtitle><date>1992-07-31</date><risdate>1992</risdate><volume>257</volume><issue>5070</issue><spage>682</spage><epage>685</epage><pages>682-685</pages><issn>0036-8075</issn><eissn>1095-9203</eissn><abstract>A variant of the glycoprotein CD44 (CD44v) that shares sequences with variants causally involved in metastasis formation is transiently expressed on B and T lymphocytes and macrophages after antigenic stimulation and in the postnatal period. Antibodies to the variant hinder in vivo activation of both B and T cells. The observation that a protein domain that is expressed on CD44 and required for the lymphatic spread of tumor cells can catalyze an essential step in the process of lymphocyte activation supports the idea that metastasizing tumor cells mimic lymphocyte behavior.</abstract><cop>United States</cop><pub>American Society for the Advancement of Science</pub><pmid>1496383</pmid><doi>10.1126/science.1496383</doi><tpages>4</tpages></addata></record> |
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| identifier | ISSN: 0036-8075 |
| ispartof | Science (American Association for the Advancement of Science), 1992-07, Vol.257 (5070), p.682-685 |
| issn | 0036-8075 1095-9203 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_73097222 |
| source | MEDLINE; American Association for the Advancement of Science; Jstor Complete Legacy |
| subjects | Animals Antibodies Antibodies, Monoclonal Antigen presenting cells B lymphocytes B-Lymphocytes - immunology Base Sequence Blotting, Northern Bone marrow cells Cancer metastasis Cell adhesion molecules DNA - chemistry Epitopes Exons Genetic aspects Genetic Variation Immune response Lymph nodes Lymphocyte Activation Lymphocytes Metastasis Molecular Sequence Data Neoplasm Metastasis - immunology Rats Receptors, Lymphocyte Homing - analysis Receptors, Lymphocyte Homing - genetics Receptors, Lymphocyte Homing - immunology T lymphocytes T-Lymphocytes - immunology Tumor Cells, Cultured Tumors |
| title | Participation in Normal Immune Responses of a Metastasis-Inducing Splice Variant of CD44 |
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