Inhibition of Growth Hormone Excess Reduces Insulin Resistance and Ovarian Dysfunction in a Lean Case of Polycystic Ovary Syndrome with a Growth-Hormone-Producing Pituitary Adenoma
A 23-year-old female with polycystic ovary syndrome (PCOS) and a growth-hormone (GH)-producing pituitary adenoma is described. A reduction in the elevated GH levels to normal levels following the administration of dopaminergic agents decreased plasma insulin-like growth factor (IGF)-1 and ovarian dy...
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| Veröffentlicht in: | Hormone research 2003-01, Vol.59 (3), p.149-155 |
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| creator | Hashimoto, Shigeatsu Yatabe, Jun-ichi Midorikawa, Sanae Sanada, Hironobu Watanabe, Tsuyoshi |
| description | A 23-year-old female with polycystic ovary syndrome (PCOS) and a growth-hormone (GH)-producing pituitary adenoma is described. A reduction in the elevated GH levels to normal levels following the administration of dopaminergic agents decreased plasma insulin-like growth factor (IGF)-1 and ovarian dysfunction. Menstrual cycles were therefore restored and the number of ovarian cysts reduced, suggesting that insulin and/or IGF-1, stimulators of theca cell proliferation, may be pathogenetic factors in PCOS. |
| doi_str_mv | 10.1159/000069064 |
| format | Article |
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A reduction in the elevated GH levels to normal levels following the administration of dopaminergic agents decreased plasma insulin-like growth factor (IGF)-1 and ovarian dysfunction. Menstrual cycles were therefore restored and the number of ovarian cysts reduced, suggesting that insulin and/or IGF-1, stimulators of theca cell proliferation, may be pathogenetic factors in PCOS.</description><identifier>ISSN: 1663-2818</identifier><identifier>ISSN: 0301-0163</identifier><identifier>EISSN: 1663-2826</identifier><identifier>DOI: 10.1159/000069064</identifier><identifier>PMID: 12637795</identifier><language>eng</language><publisher>Basel, Switzerland: S. Karger AG</publisher><subject>Acanthosis Nigricans - complications ; Acromegaly - complications ; Adenoma - metabolism ; Adult ; Bromocriptine - therapeutic use ; Case Report ; Dopamine Agents - therapeutic use ; Female ; Glucose Tolerance Test ; Human Growth Hormone - antagonists & inhibitors ; Human Growth Hormone - biosynthesis ; Humans ; Insulin - physiology ; Insulin resistance ; Insulin Resistance - physiology ; Insulin-Like Growth Factor I - physiology ; Lisuride - analogs & derivatives ; Lisuride - therapeutic use ; Magnetic Resonance Imaging ; Menstrual Cycle - drug effects ; Ovary - pathology ; Ovary - physiopathology ; Pancreatic Function Tests ; Pituitary Function Tests ; Pituitary Neoplasms - metabolism ; Polycystic Ovary Syndrome - drug therapy ; Polycystic Ovary Syndrome - pathology ; Polycystic Ovary Syndrome - physiopathology ; Theca Cells - physiology</subject><ispartof>Hormone research, 2003-01, Vol.59 (3), p.149-155</ispartof><rights>2003 S. 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complications</topic><topic>Acromegaly - complications</topic><topic>Adenoma - metabolism</topic><topic>Adult</topic><topic>Bromocriptine - therapeutic use</topic><topic>Case Report</topic><topic>Dopamine Agents - therapeutic use</topic><topic>Female</topic><topic>Glucose Tolerance Test</topic><topic>Human Growth Hormone - antagonists & inhibitors</topic><topic>Human Growth Hormone - biosynthesis</topic><topic>Humans</topic><topic>Insulin - physiology</topic><topic>Insulin resistance</topic><topic>Insulin Resistance - physiology</topic><topic>Insulin-Like Growth Factor I - physiology</topic><topic>Lisuride - analogs & derivatives</topic><topic>Lisuride - therapeutic use</topic><topic>Magnetic Resonance Imaging</topic><topic>Menstrual Cycle - drug effects</topic><topic>Ovary - pathology</topic><topic>Ovary - physiopathology</topic><topic>Pancreatic Function Tests</topic><topic>Pituitary Function Tests</topic><topic>Pituitary Neoplasms - metabolism</topic><topic>Polycystic Ovary Syndrome - drug therapy</topic><topic>Polycystic Ovary Syndrome - pathology</topic><topic>Polycystic Ovary Syndrome - physiopathology</topic><topic>Theca Cells - physiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hashimoto, Shigeatsu</creatorcontrib><creatorcontrib>Yatabe, Jun-ichi</creatorcontrib><creatorcontrib>Midorikawa, Sanae</creatorcontrib><creatorcontrib>Sanada, Hironobu</creatorcontrib><creatorcontrib>Watanabe, Tsuyoshi</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database</collection><collection>Toxicology Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Technology Research Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>Consumer Health Database (Alumni Edition)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Consumer Health Database</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Nursing & Allied Health Premium</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Hormone research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hashimoto, Shigeatsu</au><au>Yatabe, Jun-ichi</au><au>Midorikawa, Sanae</au><au>Sanada, Hironobu</au><au>Watanabe, Tsuyoshi</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Inhibition of Growth Hormone Excess Reduces Insulin Resistance and Ovarian Dysfunction in a Lean Case of Polycystic Ovary Syndrome with a Growth-Hormone-Producing Pituitary Adenoma</atitle><jtitle>Hormone research</jtitle><addtitle>Horm Res Paediatr</addtitle><date>2003-01-01</date><risdate>2003</risdate><volume>59</volume><issue>3</issue><spage>149</spage><epage>155</epage><pages>149-155</pages><issn>1663-2818</issn><issn>0301-0163</issn><eissn>1663-2826</eissn><abstract>A 23-year-old female with polycystic ovary syndrome (PCOS) and a growth-hormone (GH)-producing pituitary adenoma is described. A reduction in the elevated GH levels to normal levels following the administration of dopaminergic agents decreased plasma insulin-like growth factor (IGF)-1 and ovarian dysfunction. Menstrual cycles were therefore restored and the number of ovarian cysts reduced, suggesting that insulin and/or IGF-1, stimulators of theca cell proliferation, may be pathogenetic factors in PCOS.</abstract><cop>Basel, Switzerland</cop><pub>S. Karger AG</pub><pmid>12637795</pmid><doi>10.1159/000069064</doi><tpages>7</tpages></addata></record> |
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| ispartof | Hormone research, 2003-01, Vol.59 (3), p.149-155 |
| issn | 1663-2818 0301-0163 1663-2826 |
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| source | MEDLINE; Karger Journals; Alma/SFX Local Collection |
| subjects | Acanthosis Nigricans - complications Acromegaly - complications Adenoma - metabolism Adult Bromocriptine - therapeutic use Case Report Dopamine Agents - therapeutic use Female Glucose Tolerance Test Human Growth Hormone - antagonists & inhibitors Human Growth Hormone - biosynthesis Humans Insulin - physiology Insulin resistance Insulin Resistance - physiology Insulin-Like Growth Factor I - physiology Lisuride - analogs & derivatives Lisuride - therapeutic use Magnetic Resonance Imaging Menstrual Cycle - drug effects Ovary - pathology Ovary - physiopathology Pancreatic Function Tests Pituitary Function Tests Pituitary Neoplasms - metabolism Polycystic Ovary Syndrome - drug therapy Polycystic Ovary Syndrome - pathology Polycystic Ovary Syndrome - physiopathology Theca Cells - physiology |
| title | Inhibition of Growth Hormone Excess Reduces Insulin Resistance and Ovarian Dysfunction in a Lean Case of Polycystic Ovary Syndrome with a Growth-Hormone-Producing Pituitary Adenoma |
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