The matrix metalloproteinases and their natural inhibitors: prospects for treating degenerative tissue diseases
Uncontrolled matrix metalloproteinase activity is thought to be a cause of the tissue damage observed in many disease processes. None of the drugs currently in use can prevent tissue destruction, and strategies for the development of synthetic inhibitors have been hampered by a poor understanding of...
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| Veröffentlicht in: | Trends in biotechnology (Regular ed.) 1992-06, Vol.10 (6), p.200-207 |
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| container_end_page | 207 |
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| container_issue | 6 |
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| container_title | Trends in biotechnology (Regular ed.) |
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| creator | Docherty, Andrew J.P. O'Connell, James Crabbe, Tom Angal, Sarojani Murphy, Gillian |
| description | Uncontrolled matrix metalloproteinase activity is thought to be a cause of the tissue damage observed in many disease processes. None of the drugs currently in use can prevent tissue destruction, and strategies for the development of synthetic inhibitors have been hampered by a poor understanding of the biochemistry of matrix metalloproteinases. Recent cDNA cloning efforts and characterization of recombinant human matrix metalloproteinases have permitted structure-function analysis of the enzymes and their inhibitors. Progress in this area should help indicate a route to rational strategies for designing lead therapeutic compounds. |
| doi_str_mv | 10.1016/0167-7799(92)90214-G |
| format | Article |
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| fulltext | fulltext |
| identifier | ISSN: 0167-7799 |
| ispartof | Trends in biotechnology (Regular ed.), 1992-06, Vol.10 (6), p.200-207 |
| issn | 0167-7799 1879-3096 |
| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Amino Acid Sequence Analytical, structural and metabolic biochemistry Animals Biological and medical sciences Biotechnology Cloning, Molecular Connective Tissue Diseases - drug therapy Connective Tissue Diseases - enzymology Enzymes and enzyme inhibitors Extracellular Matrix - enzymology Fundamental and applied biological sciences. Psychology Humans Hydrolases Metalloendopeptidases - antagonists & inhibitors Metalloendopeptidases - genetics Metalloendopeptidases - metabolism Molecular Sequence Data |
| title | The matrix metalloproteinases and their natural inhibitors: prospects for treating degenerative tissue diseases |
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