Effect of human airway trypsin-like protease on intracellular free Ca2+ concentration in human bronchial epithelial cells

It has been shown that human airway trypsin-like protease (HAT) is localized in human bronchial epithelial cells (HBEC), and trypsin activates protease-activated receptor-2 (PAR-2). Activation of PAR-2 activates G-protein followed by an increase of intracellular free Ca2+, [Ca2+]in. This study was u...

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Veröffentlicht in:	The journal of medical investigation 2003-02, Vol.50 (1-2), p.95-107
Hauptverfasser:	Miki, Mari, Nakamura, Yoichi, Takahashi, Akira, Nakaya, Yutaka, Eguchi, Hiroshi, Masegi, Tsukio, Yoneda, Kazuo, Yasuoka, Susumu, Sone, Saburo
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Bronchi - cytology Calcium - metabolism Calcium - pharmacology Calcium Signaling - drug effects Calcium Signaling - physiology Cell Line, Transformed - drug effects Cell Line, Transformed - metabolism Cells, Cultured - drug effects Cells, Cultured - metabolism Culture Media - pharmacology Enzyme Induction Epithelial Cells - drug effects Epithelial Cells - metabolism Fibroblasts - drug effects Fibroblasts - metabolism Humans Intracellular Fluid - drug effects Ion Transport - drug effects Lung - cytology Macrophages, Alveolar - drug effects Macrophages, Alveolar - metabolism Peptide Fragments - pharmacology Receptor, PAR-1 Receptor, PAR-2 Receptors, Thrombin - agonists Receptors, Thrombin - biosynthesis Receptors, Thrombin - drug effects Receptors, Thrombin - genetics Receptors, Thrombin - physiology Recombinant Fusion Proteins - pharmacology RNA, Messenger - biosynthesis Serine Endopeptidases - biosynthesis Serine Endopeptidases - genetics Serine Endopeptidases - pharmacology Serine Endopeptidases - physiology
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