Stimulation by food proteins plays a critical role in the maturation of the immune system
The majority of contacts with foreign antigenic materials occur on the gut mucosa, and are represented by food proteins and the autochthonous microbiota. In the present study, we replaced intact dietary proteins by equivalent amounts of amino acids from weaning on and investigated its effects on the...
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Veröffentlicht in: | International immunology 2003-03, Vol.15 (3), p.447-455 |
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creator | da Silva Menezes, Juscilene de Sousa Mucida, Daniel Cara, Denise Carmona Alvarez‐Leite, Jacqueline Isaura Russo, Momtchilo Vaz, Nelson Monteiro de Faria, Ana Maria Caetano |
description | The majority of contacts with foreign antigenic materials occur on the gut mucosa, and are represented by food proteins and the autochthonous microbiota. In the present study, we replaced intact dietary proteins by equivalent amounts of amino acids from weaning on and investigated its effects on the development of the immune system of mice. Adult animals reared on a balanced protein‐free diet (Aa‐mice) have a poorly developed gut‐associated lymphoid tissue resembling suckling mice. They also display low numbers of lamina propria cells and TCRαβ intraepithelial lymphocytes, and low levels of secretory IgA. Levels of circulating IgG and IgA are also reduced in Aa‐mice, whereas IgM levels are normal. In vitro cytokine production by cells from several lymphoid organs shows a predominant Th2 profile with a high concentration of IL‐10 and IL‐4, and a low concentration of IFN‐γ. These parameters also resemble the immunological patterns observed in pre‐weaned mice. Thus, our data clearly show that exposure to food proteins after weaning has a physiological role in the maturation of the immune system both locally and systemically. |
doi_str_mv | 10.1093/intimm/dxg043 |
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In the present study, we replaced intact dietary proteins by equivalent amounts of amino acids from weaning on and investigated its effects on the development of the immune system of mice. Adult animals reared on a balanced protein‐free diet (Aa‐mice) have a poorly developed gut‐associated lymphoid tissue resembling suckling mice. They also display low numbers of lamina propria cells and TCRαβ intraepithelial lymphocytes, and low levels of secretory IgA. Levels of circulating IgG and IgA are also reduced in Aa‐mice, whereas IgM levels are normal. In vitro cytokine production by cells from several lymphoid organs shows a predominant Th2 profile with a high concentration of IL‐10 and IL‐4, and a low concentration of IFN‐γ. These parameters also resemble the immunological patterns observed in pre‐weaned mice. Thus, our data clearly show that exposure to food proteins after weaning has a physiological role in the maturation of the immune system both locally and systemically.</description><identifier>ISSN: 0953-8178</identifier><identifier>ISSN: 1460-2377</identifier><identifier>EISSN: 1460-2377</identifier><identifier>DOI: 10.1093/intimm/dxg043</identifier><identifier>PMID: 12618489</identifier><language>eng</language><publisher>England: Oxford University Press</publisher><subject>Amino Acids - metabolism ; Animals ; Antigens - immunology ; Caseins - immunology ; cytokine ; diet ; Dietary Proteins - immunology ; gut ; Immune System - growth & development ; Immune System - immunology ; Immunoglobulins - blood ; Lymphocytes - immunology ; Lymphocytes - metabolism ; maturation ; Mice ; Receptors, Antigen, T-Cell - immunology ; Receptors, Antigen, T-Cell - metabolism</subject><ispartof>International immunology, 2003-03, Vol.15 (3), p.447-455</ispartof><rights>Copyright Oxford University Press(England) Mar 2003</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c519t-cfcde3ab7c108b3e3a20e283df089c34f2213cd20c7ed7365d11d1f433f8f2253</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/12618489$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>da Silva Menezes, Juscilene</creatorcontrib><creatorcontrib>de Sousa Mucida, Daniel</creatorcontrib><creatorcontrib>Cara, Denise Carmona</creatorcontrib><creatorcontrib>Alvarez‐Leite, Jacqueline Isaura</creatorcontrib><creatorcontrib>Russo, Momtchilo</creatorcontrib><creatorcontrib>Vaz, Nelson Monteiro</creatorcontrib><creatorcontrib>de Faria, Ana Maria Caetano</creatorcontrib><title>Stimulation by food proteins plays a critical role in the maturation of the immune system</title><title>International immunology</title><addtitle>Int. Immunol</addtitle><description>The majority of contacts with foreign antigenic materials occur on the gut mucosa, and are represented by food proteins and the autochthonous microbiota. In the present study, we replaced intact dietary proteins by equivalent amounts of amino acids from weaning on and investigated its effects on the development of the immune system of mice. Adult animals reared on a balanced protein‐free diet (Aa‐mice) have a poorly developed gut‐associated lymphoid tissue resembling suckling mice. They also display low numbers of lamina propria cells and TCRαβ intraepithelial lymphocytes, and low levels of secretory IgA. Levels of circulating IgG and IgA are also reduced in Aa‐mice, whereas IgM levels are normal. In vitro cytokine production by cells from several lymphoid organs shows a predominant Th2 profile with a high concentration of IL‐10 and IL‐4, and a low concentration of IFN‐γ. 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Thus, our data clearly show that exposure to food proteins after weaning has a physiological role in the maturation of the immune system both locally and systemically.</description><subject>Amino Acids - metabolism</subject><subject>Animals</subject><subject>Antigens - immunology</subject><subject>Caseins - immunology</subject><subject>cytokine</subject><subject>diet</subject><subject>Dietary Proteins - immunology</subject><subject>gut</subject><subject>Immune System - growth & development</subject><subject>Immune System - immunology</subject><subject>Immunoglobulins - blood</subject><subject>Lymphocytes - immunology</subject><subject>Lymphocytes - metabolism</subject><subject>maturation</subject><subject>Mice</subject><subject>Receptors, Antigen, T-Cell - immunology</subject><subject>Receptors, Antigen, T-Cell - metabolism</subject><issn>0953-8178</issn><issn>1460-2377</issn><issn>1460-2377</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2003</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkU1vFDEMhiNERbcLR64o4tDbtEk8M0mOqKItqCoHCipcomw-IGVmsiQZqfvvSZlVK3HhZMt-_Mr2i9BrSk4okXAaphLG8dTe_yAtPEMr2vakYcD5c7QisoNGUC4O0VHOd4QQYBJeoEPKeipaIVfo2-c6Pg-6hDjhzQ77GC3eplhcmDLeDnqXscYmhRKMHnCKg8NhwuWnw6Muc1oGo_9bqYvMk8N5l4sbX6IDr4fsXu3jGn05f39zdtlcfbr4cPbuqjEdlaUx3lgHesMNJWIDNWXEMQHWEyENtJ4xCsYyYrizHPrOUmqpbwG8qL0O1uh40a1b_55dLmoM2bhh0JOLc1YciGyB0_-CVPSyf3jZGr39B7yLc5rqEYrKjjDRM1ahZoFMijkn59U2hVGnnaJEPTijFmfU4kzl3-xF583o7BO9t-JJMNTv3T_2dfqleg68U5e339X57cebr9fiQnXwB0EOm2I</recordid><startdate>200303</startdate><enddate>200303</enddate><creator>da Silva Menezes, Juscilene</creator><creator>de Sousa Mucida, Daniel</creator><creator>Cara, Denise Carmona</creator><creator>Alvarez‐Leite, Jacqueline Isaura</creator><creator>Russo, Momtchilo</creator><creator>Vaz, Nelson Monteiro</creator><creator>de Faria, Ana Maria Caetano</creator><general>Oxford University Press</general><general>Oxford Publishing Limited (England)</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QL</scope><scope>7QP</scope><scope>7QR</scope><scope>7T5</scope><scope>7T7</scope><scope>7TK</scope><scope>7U9</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>H94</scope><scope>K9.</scope><scope>M7N</scope><scope>P64</scope><scope>7X8</scope></search><sort><creationdate>200303</creationdate><title>Stimulation by food proteins plays a critical role in the maturation of the immune system</title><author>da Silva Menezes, Juscilene ; 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subjects | Amino Acids - metabolism Animals Antigens - immunology Caseins - immunology cytokine diet Dietary Proteins - immunology gut Immune System - growth & development Immune System - immunology Immunoglobulins - blood Lymphocytes - immunology Lymphocytes - metabolism maturation Mice Receptors, Antigen, T-Cell - immunology Receptors, Antigen, T-Cell - metabolism |
title | Stimulation by food proteins plays a critical role in the maturation of the immune system |
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