The inhibition of phosphatidylinositol 3-kinase by quercetin and analogs

Phosphatidylinositol (Ptdlns) 3-kinase is an enzyme involved in cellular responses to growth factors. Quercetin (2-(3,4-dihydroxyphenyl)-3,5,7-trihydroxy-4H-1-benzopyrano-4-one), a naturally occuring bioflavinoid, was found to inhibit Ptdlns 3-kinase with an IC 50 of 1.3 μg/ml (3.8 μM); inhibition a...

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Veröffentlicht in:	Biochemical and biophysical research communications 1992-07, Vol.186 (2), p.624-631
Hauptverfasser:	Matter, William F., Brown, Raymond F., Vlahos, Chris J.
Format:	Artikel
Sprache:	eng
Schlagworte:	1-phosphatidylinositol 3-kinase Analytical, structural and metabolic biochemistry Animals Biological and medical sciences Brain - enzymology Cattle Enzymes and enzyme inhibitors Flavonoids - pharmacology Fundamental and applied biological sciences. Psychology inhibition Kinetics Molecular Structure Phosphatidylinositol 3-Kinases Phosphotransferases - antagonists & inhibitors Phosphotransferases - isolation & purification Quercetin - analogs & derivatives Quercetin - pharmacology querecetin Structure-Activity Relationship Transferases
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