Allelic variation in the serotonin transporter promoter affects neuromodulatory effects of a selective serotonin transporter reuptake inhibitor (SSRI)
Antidepressant efficacy of selective serotonin reuptake inhibitors (SSRIs) has been shown to depend on functional polymorphisms within the promoter region of the serotonin transporter gene (5-HTTLPR). This gene gives rise to a biallelic polymorphism designated long (l) and short (s). Homozygosity fo...
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| Veröffentlicht in: | Psychopharmacologia 2003-03, Vol.166 (3), p.294-297 |
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| creator | EICHHAMMER, Peter LANGGUTH, Berthold WIEGAND, Rainer KHARRAZ, Alexander FRICK, Ulrich HAJAK, Göran |
| description | Antidepressant efficacy of selective serotonin reuptake inhibitors (SSRIs) has been shown to depend on functional polymorphisms within the promoter region of the serotonin transporter gene (5-HTTLPR). This gene gives rise to a biallelic polymorphism designated long (l) and short (s). Homozygosity for the long variant (ll-genotype) is associated with a two times more efficient 5-HT uptake compared to the s/l- or s/s-genotype. Paired pulse transcranial magnetic stimulation is a feasible tool in detecting changes of motor cortex excitability induced by SSRIs.
Our study aimed to measure neuromodulatory effects of SSRIs on cortical excitability in healthy volunteers characterized by distinct genotypes of the 5-HTTLPR.
Cortical excitability was determined in eight genetically defined subjects pre- and post-ingestion of 60 mg citalopram.
Subjects with the ll-genotype of the 5-HTTLPR showed a significant enhancement of a particular component of motor cortex excitability (intracortical inhibition) as compared to volunteers without the ll-genotype.
Distinct neuromodulatory effects after intake of citalopram based on allelic variations of the 5-HTTLPR may explain variable response of patients treated with SSRIs. |
| doi_str_mv | 10.1007/s00213-002-1370-1 |
| format | Article |
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Our study aimed to measure neuromodulatory effects of SSRIs on cortical excitability in healthy volunteers characterized by distinct genotypes of the 5-HTTLPR.
Cortical excitability was determined in eight genetically defined subjects pre- and post-ingestion of 60 mg citalopram.
Subjects with the ll-genotype of the 5-HTTLPR showed a significant enhancement of a particular component of motor cortex excitability (intracortical inhibition) as compared to volunteers without the ll-genotype.
Distinct neuromodulatory effects after intake of citalopram based on allelic variations of the 5-HTTLPR may explain variable response of patients treated with SSRIs.</description><identifier>ISSN: 0033-3158</identifier><identifier>EISSN: 1432-2072</identifier><identifier>DOI: 10.1007/s00213-002-1370-1</identifier><identifier>PMID: 12563545</identifier><identifier>CODEN: PSYPAG</identifier><language>eng</language><publisher>Berlin: Springer</publisher><subject>Adult ; Alleles ; Biological and medical sciences ; Carrier Proteins - genetics ; Citalopram - blood ; Citalopram - pharmacology ; Electrophysiology ; Genotype ; Humans ; Magnetic Resonance Imaging ; Medical sciences ; Membrane Glycoproteins - genetics ; Membrane Transport Proteins ; Motor Cortex - anatomy & histology ; Motor Cortex - drug effects ; Nerve Tissue Proteins ; Nervous System - drug effects ; Neuropharmacology ; Pharmacology. Drug treatments ; Polymorphism, Genetic - genetics ; Promoter Regions, Genetic - genetics ; Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer..., (alzheimer disease) ; Psychology. Psychoanalysis. Psychiatry ; Psychopharmacology ; Reflex, Startle - drug effects ; Serotonin Plasma Membrane Transport Proteins ; Serotonin Uptake Inhibitors - blood ; Serotonin Uptake Inhibitors - pharmacology</subject><ispartof>Psychopharmacologia, 2003-03, Vol.166 (3), p.294-297</ispartof><rights>2003 INIST-CNRS</rights><rights>Copyright Springer-Verlag 2003</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c385t-bad24c3416307e7c7fd36cbbef4ac5a290a3826252ac8cb7ea5e2631caca27f43</citedby><cites>FETCH-LOGICAL-c385t-bad24c3416307e7c7fd36cbbef4ac5a290a3826252ac8cb7ea5e2631caca27f43</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=14615977$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/12563545$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>EICHHAMMER, Peter</creatorcontrib><creatorcontrib>LANGGUTH, Berthold</creatorcontrib><creatorcontrib>WIEGAND, Rainer</creatorcontrib><creatorcontrib>KHARRAZ, Alexander</creatorcontrib><creatorcontrib>FRICK, Ulrich</creatorcontrib><creatorcontrib>HAJAK, Göran</creatorcontrib><title>Allelic variation in the serotonin transporter promoter affects neuromodulatory effects of a selective serotonin transporter reuptake inhibitor (SSRI)</title><title>Psychopharmacologia</title><addtitle>Psychopharmacology (Berl)</addtitle><description>Antidepressant efficacy of selective serotonin reuptake inhibitors (SSRIs) has been shown to depend on functional polymorphisms within the promoter region of the serotonin transporter gene (5-HTTLPR). This gene gives rise to a biallelic polymorphism designated long (l) and short (s). Homozygosity for the long variant (ll-genotype) is associated with a two times more efficient 5-HT uptake compared to the s/l- or s/s-genotype. Paired pulse transcranial magnetic stimulation is a feasible tool in detecting changes of motor cortex excitability induced by SSRIs.
Our study aimed to measure neuromodulatory effects of SSRIs on cortical excitability in healthy volunteers characterized by distinct genotypes of the 5-HTTLPR.
Cortical excitability was determined in eight genetically defined subjects pre- and post-ingestion of 60 mg citalopram.
Subjects with the ll-genotype of the 5-HTTLPR showed a significant enhancement of a particular component of motor cortex excitability (intracortical inhibition) as compared to volunteers without the ll-genotype.
Distinct neuromodulatory effects after intake of citalopram based on allelic variations of the 5-HTTLPR may explain variable response of patients treated with SSRIs.</description><subject>Adult</subject><subject>Alleles</subject><subject>Biological and medical sciences</subject><subject>Carrier Proteins - genetics</subject><subject>Citalopram - blood</subject><subject>Citalopram - pharmacology</subject><subject>Electrophysiology</subject><subject>Genotype</subject><subject>Humans</subject><subject>Magnetic Resonance Imaging</subject><subject>Medical sciences</subject><subject>Membrane Glycoproteins - genetics</subject><subject>Membrane Transport Proteins</subject><subject>Motor Cortex - anatomy & histology</subject><subject>Motor Cortex - drug effects</subject><subject>Nerve Tissue Proteins</subject><subject>Nervous System - drug effects</subject><subject>Neuropharmacology</subject><subject>Pharmacology. 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Psychiatry</subject><subject>Psychopharmacology</subject><subject>Reflex, Startle - drug effects</subject><subject>Serotonin Plasma Membrane Transport Proteins</subject><subject>Serotonin Uptake Inhibitors - blood</subject><subject>Serotonin Uptake Inhibitors - pharmacology</subject><issn>0033-3158</issn><issn>1432-2072</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2003</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNqFkd1qFTEQgIMo9lh9AG8kCBW9WM3vZs9lKf4UCoLV6zCbM6GpOZtjki30RXxes5yFgiDmYpIZvnxhMoS85Ow9Z8x8KIwJLrsWOy4N6_gjsuFKik4wIx6TDWNSdpLr4YQ8K-WWtaUG9ZSccKF7qZXekN_nMWIMjt5BDlBDmmiYaL1BWjCnmqYlyzCVQ8oVMz3ktE_LAbxHVwudcF5KuzlCTfme4lpPnkJzxJaEu3_ZMs6HCj-xvXkTxtAE9O319bfLd8_JEw-x4It1PyU_Pn38fvGlu_r6-fLi_KpzctC1G2EnlJOK95IZNM74nezdOKJX4DSILQM5iF5oAW5wo0HQKHrJHTgQxit5St4cva2vXzOWavehOIwRJkxzsUayrdRC_xcUbBgEk7yBr_8Cb9Ocp9aEFXzY6oHpxcaPkMuplIzeHnLYQ763nNlltPY4WtuiXUZrF_GrVTyPe9w93Fhn2YCzFYDiIPr2zy6UB071XG-NkX8AvWavjQ</recordid><startdate>20030301</startdate><enddate>20030301</enddate><creator>EICHHAMMER, Peter</creator><creator>LANGGUTH, Berthold</creator><creator>WIEGAND, Rainer</creator><creator>KHARRAZ, Alexander</creator><creator>FRICK, Ulrich</creator><creator>HAJAK, Göran</creator><general>Springer</general><general>Springer Nature B.V</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QG</scope><scope>7QR</scope><scope>7RV</scope><scope>7TK</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88G</scope><scope>8AO</scope><scope>8FD</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>K9.</scope><scope>KB0</scope><scope>M0S</scope><scope>M1P</scope><scope>M2M</scope><scope>NAPCQ</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PSYQQ</scope><scope>Q9U</scope><scope>RC3</scope><scope>7X8</scope></search><sort><creationdate>20030301</creationdate><title>Allelic variation in the serotonin transporter promoter affects neuromodulatory effects of a selective serotonin transporter reuptake inhibitor (SSRI)</title><author>EICHHAMMER, Peter ; LANGGUTH, Berthold ; WIEGAND, Rainer ; KHARRAZ, Alexander ; FRICK, Ulrich ; HAJAK, Göran</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c385t-bad24c3416307e7c7fd36cbbef4ac5a290a3826252ac8cb7ea5e2631caca27f43</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2003</creationdate><topic>Adult</topic><topic>Alleles</topic><topic>Biological and medical sciences</topic><topic>Carrier Proteins - genetics</topic><topic>Citalopram - blood</topic><topic>Citalopram - pharmacology</topic><topic>Electrophysiology</topic><topic>Genotype</topic><topic>Humans</topic><topic>Magnetic Resonance Imaging</topic><topic>Medical sciences</topic><topic>Membrane Glycoproteins - genetics</topic><topic>Membrane Transport Proteins</topic><topic>Motor Cortex - anatomy & histology</topic><topic>Motor Cortex - drug effects</topic><topic>Nerve Tissue Proteins</topic><topic>Nervous System - drug effects</topic><topic>Neuropharmacology</topic><topic>Pharmacology. Drug treatments</topic><topic>Polymorphism, Genetic - genetics</topic><topic>Promoter Regions, Genetic - genetics</topic><topic>Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer..., (alzheimer disease)</topic><topic>Psychology. Psychoanalysis. Psychiatry</topic><topic>Psychopharmacology</topic><topic>Reflex, Startle - drug effects</topic><topic>Serotonin Plasma Membrane Transport Proteins</topic><topic>Serotonin Uptake Inhibitors - blood</topic><topic>Serotonin Uptake Inhibitors - pharmacology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>EICHHAMMER, Peter</creatorcontrib><creatorcontrib>LANGGUTH, Berthold</creatorcontrib><creatorcontrib>WIEGAND, Rainer</creatorcontrib><creatorcontrib>KHARRAZ, Alexander</creatorcontrib><creatorcontrib>FRICK, Ulrich</creatorcontrib><creatorcontrib>HAJAK, Göran</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Animal Behavior Abstracts</collection><collection>Chemoreception Abstracts</collection><collection>ProQuest Nursing & Allied Health Database</collection><collection>Neurosciences Abstracts</collection><collection>ProQuest_Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Psychology Database (Alumni)</collection><collection>ProQuest Pharma Collection</collection><collection>Technology Research Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Psychology Database</collection><collection>Nursing & Allied Health Premium</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest One Psychology</collection><collection>ProQuest Central Basic</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Psychopharmacologia</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>EICHHAMMER, Peter</au><au>LANGGUTH, Berthold</au><au>WIEGAND, Rainer</au><au>KHARRAZ, Alexander</au><au>FRICK, Ulrich</au><au>HAJAK, Göran</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Allelic variation in the serotonin transporter promoter affects neuromodulatory effects of a selective serotonin transporter reuptake inhibitor (SSRI)</atitle><jtitle>Psychopharmacologia</jtitle><addtitle>Psychopharmacology (Berl)</addtitle><date>2003-03-01</date><risdate>2003</risdate><volume>166</volume><issue>3</issue><spage>294</spage><epage>297</epage><pages>294-297</pages><issn>0033-3158</issn><eissn>1432-2072</eissn><coden>PSYPAG</coden><abstract>Antidepressant efficacy of selective serotonin reuptake inhibitors (SSRIs) has been shown to depend on functional polymorphisms within the promoter region of the serotonin transporter gene (5-HTTLPR). This gene gives rise to a biallelic polymorphism designated long (l) and short (s). Homozygosity for the long variant (ll-genotype) is associated with a two times more efficient 5-HT uptake compared to the s/l- or s/s-genotype. Paired pulse transcranial magnetic stimulation is a feasible tool in detecting changes of motor cortex excitability induced by SSRIs.
Our study aimed to measure neuromodulatory effects of SSRIs on cortical excitability in healthy volunteers characterized by distinct genotypes of the 5-HTTLPR.
Cortical excitability was determined in eight genetically defined subjects pre- and post-ingestion of 60 mg citalopram.
Subjects with the ll-genotype of the 5-HTTLPR showed a significant enhancement of a particular component of motor cortex excitability (intracortical inhibition) as compared to volunteers without the ll-genotype.
Distinct neuromodulatory effects after intake of citalopram based on allelic variations of the 5-HTTLPR may explain variable response of patients treated with SSRIs.</abstract><cop>Berlin</cop><pub>Springer</pub><pmid>12563545</pmid><doi>10.1007/s00213-002-1370-1</doi><tpages>4</tpages></addata></record> |
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| subjects | Adult Alleles Biological and medical sciences Carrier Proteins - genetics Citalopram - blood Citalopram - pharmacology Electrophysiology Genotype Humans Magnetic Resonance Imaging Medical sciences Membrane Glycoproteins - genetics Membrane Transport Proteins Motor Cortex - anatomy & histology Motor Cortex - drug effects Nerve Tissue Proteins Nervous System - drug effects Neuropharmacology Pharmacology. Drug treatments Polymorphism, Genetic - genetics Promoter Regions, Genetic - genetics Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer..., (alzheimer disease) Psychology. Psychoanalysis. Psychiatry Psychopharmacology Reflex, Startle - drug effects Serotonin Plasma Membrane Transport Proteins Serotonin Uptake Inhibitors - blood Serotonin Uptake Inhibitors - pharmacology |
| title | Allelic variation in the serotonin transporter promoter affects neuromodulatory effects of a selective serotonin transporter reuptake inhibitor (SSRI) |
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