Effects of AICAR and exercise on insulin-stimulated glucose uptake, signaling, and GLUT-4 content in rat muscles
1 Medical Research Laboratory and Medical Department M (Endocrinology and Diabetes), Aarhus University Hospital, Aarhus Kommunehospital, and 2 Department of Clinical Pharmacology, University of Aarhus, DK-8000 Aarhus C, Denmark Physical activity is known to increase insulin action in skeletal musc...
Gespeichert in:
| Veröffentlicht in: | Journal of applied physiology (1985) 2003-04, Vol.94 (4), p.1373-1379 |
|---|---|
| Hauptverfasser: | , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 1379 |
|---|---|
| container_issue | 4 |
| container_start_page | 1373 |
| container_title | Journal of applied physiology (1985) |
| container_volume | 94 |
| creator | Jessen, Niels Pold, Rasmus Buhl, Esben S Jensen, Lasse S Schmitz, Ole Lund, Sten |
| description | 1 Medical Research Laboratory and Medical Department
M (Endocrinology and Diabetes), Aarhus University Hospital, Aarhus
Kommunehospital, and 2 Department of Clinical
Pharmacology, University of Aarhus, DK-8000 Aarhus C,
Denmark
Physical activity is known
to increase insulin action in skeletal muscle, and data have indicated
that 5'-AMP-activated protein kinase (AMPK) is involved in the
molecular mechanisms behind this beneficial effect.
5-Aminoimidazole-4-carboxamide-1- - D -ribofuranoside (AICAR) can be used as a pharmacological tool to repetitively activate
AMPK, and the objective of this study was to explore whether the
increase in insulin-stimulated glucose uptake after either long-term
exercise or chronic AICAR administration was followed by
fiber-type-specific changes in insulin signaling and/or changes in
GLUT-4 expression. Wistar rats were allocated into three groups: an
exercise group trained on treadmill for 5 days, an AICAR group exposed
to daily subcutaneous injections of AICAR, and a sedentary control
group. AMPK activity, insulin-stimulated glucose transport, insulin
signaling, and GLUT-4 expression were determined in muscles
characterized by different fiber type compositions. Both exercised and
AICAR-injected animals displayed a fiber-type-specific increase in
glucose transport with the most marked increase in muscles with a high
content of type IIb fibers. This increase was accompanied by a
concomitant increase in GLUT-4 expression. Insulin signaling as
assessed by phosphatidylinositol 3-kinase and PKB/Akt activity was
enhanced only after AICAR administration and in a
non-fiber-type-specific manner. In conclusion, chronic AICAR
administration and long-term exercise both improve insulin-stimulated glucose transport in skeletal muscle in a fiber-type-specific way, and
this is associated with an increase in GLUT-4 content.
glucose transport; AMP-activated protein kinase; skeletal muscle; insulin signaling; muscle fiber type |
| doi_str_mv | 10.1152/japplphysiol.00250.2002 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_highw</sourceid><recordid>TN_cdi_proquest_miscellaneous_73093436</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>73093436</sourcerecordid><originalsourceid>FETCH-LOGICAL-c510t-507355a46ccf3db3f3dc2515ab355c989c0c795bf5b29a4de335b13b283f7233</originalsourceid><addsrcrecordid>eNp1kV2L1DAUhoMo7rj6FzQIyl5sx3w208tl2Q9hQJDxOqRp0smYNrVJ2Z1_b7pTXBG8yYGc533PSV4APmC0xpiTLwc1DH7YH6MLfo0Q4WhNcnkBVrlLClwi_BKsNoKjQvCNOANvYjwghBnj-DU4w4RVJaZiBYYba41OEQYLr75eX32Hqm-geTSjdtHA0EPXx8m7vojJdZNXyTSw9ZMOuTsNSf00lzC6tleZaS-f1HfbH7uCQR36ZPqUDeCoEuymqL2Jb8Erq3w075Z6Dna3N7vr-2L77S7P3xaaY5QKjgTlXLFSa0ubmuZDE465qvO1rjaVRlpUvLa8JpVijaGU15jWZEOtIJSeg88n22EMvyYTk-xc1MZ71ZswRSkoqiijZQY__gMewjTm50RJCMFVVW5mN3GC9BhiHI2Vw-g6NR4lRnIORP4diHwKRM6BZOX7xX6qO9M865YEMvBpAVTUyttR9fnnnzlWsrISLHPsxO1du39wo5HLtNAe5e3k_c48pnmNikkmZ2c5NDbLLv4vy7T8g9PfEWC4LQ</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>222199683</pqid></control><display><type>article</type><title>Effects of AICAR and exercise on insulin-stimulated glucose uptake, signaling, and GLUT-4 content in rat muscles</title><source>MEDLINE</source><source>American Physiological Society</source><source>EZB-FREE-00999 freely available EZB journals</source><source>Alma/SFX Local Collection</source><creator>Jessen, Niels ; Pold, Rasmus ; Buhl, Esben S ; Jensen, Lasse S ; Schmitz, Ole ; Lund, Sten</creator><creatorcontrib>Jessen, Niels ; Pold, Rasmus ; Buhl, Esben S ; Jensen, Lasse S ; Schmitz, Ole ; Lund, Sten</creatorcontrib><description>1 Medical Research Laboratory and Medical Department
M (Endocrinology and Diabetes), Aarhus University Hospital, Aarhus
Kommunehospital, and 2 Department of Clinical
Pharmacology, University of Aarhus, DK-8000 Aarhus C,
Denmark
Physical activity is known
to increase insulin action in skeletal muscle, and data have indicated
that 5'-AMP-activated protein kinase (AMPK) is involved in the
molecular mechanisms behind this beneficial effect.
5-Aminoimidazole-4-carboxamide-1- - D -ribofuranoside (AICAR) can be used as a pharmacological tool to repetitively activate
AMPK, and the objective of this study was to explore whether the
increase in insulin-stimulated glucose uptake after either long-term
exercise or chronic AICAR administration was followed by
fiber-type-specific changes in insulin signaling and/or changes in
GLUT-4 expression. Wistar rats were allocated into three groups: an
exercise group trained on treadmill for 5 days, an AICAR group exposed
to daily subcutaneous injections of AICAR, and a sedentary control
group. AMPK activity, insulin-stimulated glucose transport, insulin
signaling, and GLUT-4 expression were determined in muscles
characterized by different fiber type compositions. Both exercised and
AICAR-injected animals displayed a fiber-type-specific increase in
glucose transport with the most marked increase in muscles with a high
content of type IIb fibers. This increase was accompanied by a
concomitant increase in GLUT-4 expression. Insulin signaling as
assessed by phosphatidylinositol 3-kinase and PKB/Akt activity was
enhanced only after AICAR administration and in a
non-fiber-type-specific manner. In conclusion, chronic AICAR
administration and long-term exercise both improve insulin-stimulated glucose transport in skeletal muscle in a fiber-type-specific way, and
this is associated with an increase in GLUT-4 content.
glucose transport; AMP-activated protein kinase; skeletal muscle; insulin signaling; muscle fiber type</description><identifier>ISSN: 8750-7587</identifier><identifier>EISSN: 1522-1601</identifier><identifier>DOI: 10.1152/japplphysiol.00250.2002</identifier><identifier>PMID: 12496137</identifier><identifier>CODEN: JAPHEV</identifier><language>eng</language><publisher>Bethesda, MD: Am Physiological Soc</publisher><subject>Aminoimidazole Carboxamide - analogs & derivatives ; Aminoimidazole Carboxamide - pharmacology ; AMP-Activated Protein Kinases ; Animals ; Biological and medical sciences ; Biological Transport ; Exercise ; Fundamental and applied biological sciences. Psychology ; Glucose - pharmacokinetics ; Glucose Transporter Type 4 ; Guanosine - analogs & derivatives ; Guanosine - pharmacokinetics ; Hypoglycemic Agents - pharmacology ; Immunoblotting ; Insulin ; Insulin - pharmacology ; Insulin Receptor Substrate Proteins ; Intracellular Signaling Peptides and Proteins ; Male ; Monosaccharide Transport Proteins - metabolism ; Motor Activity - physiology ; Multienzyme Complexes - metabolism ; Muscle Proteins ; Muscle, Skeletal - metabolism ; Muscular system ; Phosphatidylinositol 3-Kinases - metabolism ; Phosphoproteins - metabolism ; Phosphorylation ; Protein-Serine-Threonine Kinases - metabolism ; Proteins ; Proto-Oncogene Proteins - metabolism ; Proto-Oncogene Proteins c-akt ; Rats ; Rats, Wistar ; Ribonucleotides - pharmacology ; Rodents ; Signal Transduction - drug effects ; Skeletal system ; Striated muscle. Tendons ; Vertebrates: osteoarticular system, musculoskeletal system</subject><ispartof>Journal of applied physiology (1985), 2003-04, Vol.94 (4), p.1373-1379</ispartof><rights>2003 INIST-CNRS</rights><rights>Copyright American Physiological Society Apr 2003</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c510t-507355a46ccf3db3f3dc2515ab355c989c0c795bf5b29a4de335b13b283f7233</citedby><cites>FETCH-LOGICAL-c510t-507355a46ccf3db3f3dc2515ab355c989c0c795bf5b29a4de335b13b283f7233</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,3026,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=14646974$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/12496137$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Jessen, Niels</creatorcontrib><creatorcontrib>Pold, Rasmus</creatorcontrib><creatorcontrib>Buhl, Esben S</creatorcontrib><creatorcontrib>Jensen, Lasse S</creatorcontrib><creatorcontrib>Schmitz, Ole</creatorcontrib><creatorcontrib>Lund, Sten</creatorcontrib><title>Effects of AICAR and exercise on insulin-stimulated glucose uptake, signaling, and GLUT-4 content in rat muscles</title><title>Journal of applied physiology (1985)</title><addtitle>J Appl Physiol (1985)</addtitle><description>1 Medical Research Laboratory and Medical Department
M (Endocrinology and Diabetes), Aarhus University Hospital, Aarhus
Kommunehospital, and 2 Department of Clinical
Pharmacology, University of Aarhus, DK-8000 Aarhus C,
Denmark
Physical activity is known
to increase insulin action in skeletal muscle, and data have indicated
that 5'-AMP-activated protein kinase (AMPK) is involved in the
molecular mechanisms behind this beneficial effect.
5-Aminoimidazole-4-carboxamide-1- - D -ribofuranoside (AICAR) can be used as a pharmacological tool to repetitively activate
AMPK, and the objective of this study was to explore whether the
increase in insulin-stimulated glucose uptake after either long-term
exercise or chronic AICAR administration was followed by
fiber-type-specific changes in insulin signaling and/or changes in
GLUT-4 expression. Wistar rats were allocated into three groups: an
exercise group trained on treadmill for 5 days, an AICAR group exposed
to daily subcutaneous injections of AICAR, and a sedentary control
group. AMPK activity, insulin-stimulated glucose transport, insulin
signaling, and GLUT-4 expression were determined in muscles
characterized by different fiber type compositions. Both exercised and
AICAR-injected animals displayed a fiber-type-specific increase in
glucose transport with the most marked increase in muscles with a high
content of type IIb fibers. This increase was accompanied by a
concomitant increase in GLUT-4 expression. Insulin signaling as
assessed by phosphatidylinositol 3-kinase and PKB/Akt activity was
enhanced only after AICAR administration and in a
non-fiber-type-specific manner. In conclusion, chronic AICAR
administration and long-term exercise both improve insulin-stimulated glucose transport in skeletal muscle in a fiber-type-specific way, and
this is associated with an increase in GLUT-4 content.
glucose transport; AMP-activated protein kinase; skeletal muscle; insulin signaling; muscle fiber type</description><subject>Aminoimidazole Carboxamide - analogs & derivatives</subject><subject>Aminoimidazole Carboxamide - pharmacology</subject><subject>AMP-Activated Protein Kinases</subject><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Biological Transport</subject><subject>Exercise</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Glucose - pharmacokinetics</subject><subject>Glucose Transporter Type 4</subject><subject>Guanosine - analogs & derivatives</subject><subject>Guanosine - pharmacokinetics</subject><subject>Hypoglycemic Agents - pharmacology</subject><subject>Immunoblotting</subject><subject>Insulin</subject><subject>Insulin - pharmacology</subject><subject>Insulin Receptor Substrate Proteins</subject><subject>Intracellular Signaling Peptides and Proteins</subject><subject>Male</subject><subject>Monosaccharide Transport Proteins - metabolism</subject><subject>Motor Activity - physiology</subject><subject>Multienzyme Complexes - metabolism</subject><subject>Muscle Proteins</subject><subject>Muscle, Skeletal - metabolism</subject><subject>Muscular system</subject><subject>Phosphatidylinositol 3-Kinases - metabolism</subject><subject>Phosphoproteins - metabolism</subject><subject>Phosphorylation</subject><subject>Protein-Serine-Threonine Kinases - metabolism</subject><subject>Proteins</subject><subject>Proto-Oncogene Proteins - metabolism</subject><subject>Proto-Oncogene Proteins c-akt</subject><subject>Rats</subject><subject>Rats, Wistar</subject><subject>Ribonucleotides - pharmacology</subject><subject>Rodents</subject><subject>Signal Transduction - drug effects</subject><subject>Skeletal system</subject><subject>Striated muscle. Tendons</subject><subject>Vertebrates: osteoarticular system, musculoskeletal system</subject><issn>8750-7587</issn><issn>1522-1601</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2003</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kV2L1DAUhoMo7rj6FzQIyl5sx3w208tl2Q9hQJDxOqRp0smYNrVJ2Z1_b7pTXBG8yYGc533PSV4APmC0xpiTLwc1DH7YH6MLfo0Q4WhNcnkBVrlLClwi_BKsNoKjQvCNOANvYjwghBnj-DU4w4RVJaZiBYYba41OEQYLr75eX32Hqm-geTSjdtHA0EPXx8m7vojJdZNXyTSw9ZMOuTsNSf00lzC6tleZaS-f1HfbH7uCQR36ZPqUDeCoEuymqL2Jb8Erq3w075Z6Dna3N7vr-2L77S7P3xaaY5QKjgTlXLFSa0ubmuZDE465qvO1rjaVRlpUvLa8JpVijaGU15jWZEOtIJSeg88n22EMvyYTk-xc1MZ71ZswRSkoqiijZQY__gMewjTm50RJCMFVVW5mN3GC9BhiHI2Vw-g6NR4lRnIORP4diHwKRM6BZOX7xX6qO9M865YEMvBpAVTUyttR9fnnnzlWsrISLHPsxO1du39wo5HLtNAe5e3k_c48pnmNikkmZ2c5NDbLLv4vy7T8g9PfEWC4LQ</recordid><startdate>20030401</startdate><enddate>20030401</enddate><creator>Jessen, Niels</creator><creator>Pold, Rasmus</creator><creator>Buhl, Esben S</creator><creator>Jensen, Lasse S</creator><creator>Schmitz, Ole</creator><creator>Lund, Sten</creator><general>Am Physiological Soc</general><general>American Physiological Society</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>7QR</scope><scope>7TK</scope><scope>7TS</scope><scope>7U7</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>P64</scope><scope>7X8</scope></search><sort><creationdate>20030401</creationdate><title>Effects of AICAR and exercise on insulin-stimulated glucose uptake, signaling, and GLUT-4 content in rat muscles</title><author>Jessen, Niels ; Pold, Rasmus ; Buhl, Esben S ; Jensen, Lasse S ; Schmitz, Ole ; Lund, Sten</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c510t-507355a46ccf3db3f3dc2515ab355c989c0c795bf5b29a4de335b13b283f7233</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2003</creationdate><topic>Aminoimidazole Carboxamide - analogs & derivatives</topic><topic>Aminoimidazole Carboxamide - pharmacology</topic><topic>AMP-Activated Protein Kinases</topic><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Biological Transport</topic><topic>Exercise</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Glucose - pharmacokinetics</topic><topic>Glucose Transporter Type 4</topic><topic>Guanosine - analogs & derivatives</topic><topic>Guanosine - pharmacokinetics</topic><topic>Hypoglycemic Agents - pharmacology</topic><topic>Immunoblotting</topic><topic>Insulin</topic><topic>Insulin - pharmacology</topic><topic>Insulin Receptor Substrate Proteins</topic><topic>Intracellular Signaling Peptides and Proteins</topic><topic>Male</topic><topic>Monosaccharide Transport Proteins - metabolism</topic><topic>Motor Activity - physiology</topic><topic>Multienzyme Complexes - metabolism</topic><topic>Muscle Proteins</topic><topic>Muscle, Skeletal - metabolism</topic><topic>Muscular system</topic><topic>Phosphatidylinositol 3-Kinases - metabolism</topic><topic>Phosphoproteins - metabolism</topic><topic>Phosphorylation</topic><topic>Protein-Serine-Threonine Kinases - metabolism</topic><topic>Proteins</topic><topic>Proto-Oncogene Proteins - metabolism</topic><topic>Proto-Oncogene Proteins c-akt</topic><topic>Rats</topic><topic>Rats, Wistar</topic><topic>Ribonucleotides - pharmacology</topic><topic>Rodents</topic><topic>Signal Transduction - drug effects</topic><topic>Skeletal system</topic><topic>Striated muscle. Tendons</topic><topic>Vertebrates: osteoarticular system, musculoskeletal system</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Jessen, Niels</creatorcontrib><creatorcontrib>Pold, Rasmus</creatorcontrib><creatorcontrib>Buhl, Esben S</creatorcontrib><creatorcontrib>Jensen, Lasse S</creatorcontrib><creatorcontrib>Schmitz, Ole</creatorcontrib><creatorcontrib>Lund, Sten</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Chemoreception Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Physical Education Index</collection><collection>Toxicology Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of applied physiology (1985)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Jessen, Niels</au><au>Pold, Rasmus</au><au>Buhl, Esben S</au><au>Jensen, Lasse S</au><au>Schmitz, Ole</au><au>Lund, Sten</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effects of AICAR and exercise on insulin-stimulated glucose uptake, signaling, and GLUT-4 content in rat muscles</atitle><jtitle>Journal of applied physiology (1985)</jtitle><addtitle>J Appl Physiol (1985)</addtitle><date>2003-04-01</date><risdate>2003</risdate><volume>94</volume><issue>4</issue><spage>1373</spage><epage>1379</epage><pages>1373-1379</pages><issn>8750-7587</issn><eissn>1522-1601</eissn><coden>JAPHEV</coden><abstract>1 Medical Research Laboratory and Medical Department
M (Endocrinology and Diabetes), Aarhus University Hospital, Aarhus
Kommunehospital, and 2 Department of Clinical
Pharmacology, University of Aarhus, DK-8000 Aarhus C,
Denmark
Physical activity is known
to increase insulin action in skeletal muscle, and data have indicated
that 5'-AMP-activated protein kinase (AMPK) is involved in the
molecular mechanisms behind this beneficial effect.
5-Aminoimidazole-4-carboxamide-1- - D -ribofuranoside (AICAR) can be used as a pharmacological tool to repetitively activate
AMPK, and the objective of this study was to explore whether the
increase in insulin-stimulated glucose uptake after either long-term
exercise or chronic AICAR administration was followed by
fiber-type-specific changes in insulin signaling and/or changes in
GLUT-4 expression. Wistar rats were allocated into three groups: an
exercise group trained on treadmill for 5 days, an AICAR group exposed
to daily subcutaneous injections of AICAR, and a sedentary control
group. AMPK activity, insulin-stimulated glucose transport, insulin
signaling, and GLUT-4 expression were determined in muscles
characterized by different fiber type compositions. Both exercised and
AICAR-injected animals displayed a fiber-type-specific increase in
glucose transport with the most marked increase in muscles with a high
content of type IIb fibers. This increase was accompanied by a
concomitant increase in GLUT-4 expression. Insulin signaling as
assessed by phosphatidylinositol 3-kinase and PKB/Akt activity was
enhanced only after AICAR administration and in a
non-fiber-type-specific manner. In conclusion, chronic AICAR
administration and long-term exercise both improve insulin-stimulated glucose transport in skeletal muscle in a fiber-type-specific way, and
this is associated with an increase in GLUT-4 content.
glucose transport; AMP-activated protein kinase; skeletal muscle; insulin signaling; muscle fiber type</abstract><cop>Bethesda, MD</cop><pub>Am Physiological Soc</pub><pmid>12496137</pmid><doi>10.1152/japplphysiol.00250.2002</doi><tpages>7</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 8750-7587 |
| ispartof | Journal of applied physiology (1985), 2003-04, Vol.94 (4), p.1373-1379 |
| issn | 8750-7587 1522-1601 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_73093436 |
| source | MEDLINE; American Physiological Society; EZB-FREE-00999 freely available EZB journals; Alma/SFX Local Collection |
| subjects | Aminoimidazole Carboxamide - analogs & derivatives Aminoimidazole Carboxamide - pharmacology AMP-Activated Protein Kinases Animals Biological and medical sciences Biological Transport Exercise Fundamental and applied biological sciences. Psychology Glucose - pharmacokinetics Glucose Transporter Type 4 Guanosine - analogs & derivatives Guanosine - pharmacokinetics Hypoglycemic Agents - pharmacology Immunoblotting Insulin Insulin - pharmacology Insulin Receptor Substrate Proteins Intracellular Signaling Peptides and Proteins Male Monosaccharide Transport Proteins - metabolism Motor Activity - physiology Multienzyme Complexes - metabolism Muscle Proteins Muscle, Skeletal - metabolism Muscular system Phosphatidylinositol 3-Kinases - metabolism Phosphoproteins - metabolism Phosphorylation Protein-Serine-Threonine Kinases - metabolism Proteins Proto-Oncogene Proteins - metabolism Proto-Oncogene Proteins c-akt Rats Rats, Wistar Ribonucleotides - pharmacology Rodents Signal Transduction - drug effects Skeletal system Striated muscle. Tendons Vertebrates: osteoarticular system, musculoskeletal system |
| title | Effects of AICAR and exercise on insulin-stimulated glucose uptake, signaling, and GLUT-4 content in rat muscles |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-08T19%3A24%3A23IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_highw&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Effects%20of%20AICAR%20and%20exercise%20on%20insulin-stimulated%20glucose%20uptake,%20signaling,%20and%20GLUT-4%20content%20in%20rat%20muscles&rft.jtitle=Journal%20of%20applied%20physiology%20(1985)&rft.au=Jessen,%20Niels&rft.date=2003-04-01&rft.volume=94&rft.issue=4&rft.spage=1373&rft.epage=1379&rft.pages=1373-1379&rft.issn=8750-7587&rft.eissn=1522-1601&rft.coden=JAPHEV&rft_id=info:doi/10.1152/japplphysiol.00250.2002&rft_dat=%3Cproquest_highw%3E73093436%3C/proquest_highw%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=222199683&rft_id=info:pmid/12496137&rfr_iscdi=true |