Antihypertensive activity of the non-peptide angiotensin II receptor antagonist, SK&F 108566, in rats and dogs

The antihypertensive activity of the nonpeptide angiotensin II receptor antagonist, SK&F 108566 (E)-alpha-[[2-butyl-1-[(4-carboxyphenyl)methyl]-1H-imidazol-5- yl]methylene]-2-thiophene propanoic acid), was examined in rats and dogs. SK&F 108566 produced dose-dependent decreases in blood pres...

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Veröffentlicht in:	Naunyn-Schmiedeberg's archives of pharmacology 1992-06, Vol.345 (6), p.673-678
Hauptverfasser:	BROOKS, D. P, FREDRICKSON, T. A, WEINSTOCK, J, RUFFOLO, R. R, EDWARDS, R. M, GELLAI, M
Format:	Artikel
Sprache:	eng
Schlagworte:	Acrylates - pharmacology Angiotensin I - metabolism Angiotensin Receptor Antagonists Animals Antihypertensive agents Antihypertensive Agents - pharmacology Biological and medical sciences Biphenyl Compounds - pharmacology Cardiovascular system Dogs Hemodynamics - drug effects Hypertension - drug therapy Imidazoles - pharmacology Losartan Male Medical sciences Pharmacology. Drug treatments Rats Rats, Inbred Strains Tetrazoles - pharmacology Thiophenes
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