Transforming Growth Factor-β in Leishmanial Infection: A Parasite Escape Mechanism

The course of infection with the protozoan parasite Leishmania is determined in part by their early replication in macrophages, the exclusive host cells for these organisms. Although factors contributing to the survival of Leishmania are not well understood, cytokines influence the course of infecti...

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Veröffentlicht in:	Science (American Association for the Advancement of Science) 1992-07, Vol.257 (5069), p.545-548
Hauptverfasser:	Barral-Netto, Manoel, Barral, Aldina, Brownell, Cari E., Yasir A. W. Skeiky, Ellingsworth, Larry R., Twardzik, Daniel R., Reed, Steven G.
Format:	Artikel
Sprache:	eng
Schlagworte:	Actins - genetics Animals Base Sequence Biological and medical sciences Cytokines Development and progression Disease Susceptibility Experimental protozoal diseases and models Healing Infections Infectious diseases Interferon-gamma - genetics Interleukin-4 - genetics Leishmania - pathogenicity Leishmania - physiology Leishmaniasis Leishmaniasis, Cutaneous - immunology Leishmaniasis, Cutaneous - pathology Leishmaniasis, Cutaneous - physiopathology Lesions Macrophages Macrophages - drug effects Macrophages - parasitology Medical sciences Messenger RNA Mice Mice, Inbred BALB C Mice, Inbred C57BL Molecular Sequence Data Oligodeoxyribonucleotides Parasite hosts Parasites Parasitic diseases Polymerase Chain Reaction - methods Protozoal diseases Transforming Growth Factor beta - genetics Transforming Growth Factor beta - pharmacology Transforming Growth Factor beta - physiology Transforming growth factors
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