Cytosolic Calcium and Insulin Resistance in Elderly Patients With Essential Hypertension
We evaluated insulin sensitivity in normotensive (blood pressure, BP, < 135/85 mm Hg) and hypertensive (BP > 160/90 mm Hg) elderly subjects over 65 years old who were stratified as normal weight (body mass index, BMI, < 27) and obese (BMI > 27). Obese hypertensive individuals demonstrate...
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| Veröffentlicht in: | American journal of hypertension 1992-07, Vol.5 (7), p.459-464 |
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| container_title | American journal of hypertension |
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| creator | Byyny, Richard L. Verde, Mary Lo Lloyd, Susan Mitchell, Wayne Draznin, Boris |
| description | We evaluated insulin sensitivity in normotensive (blood pressure, BP, < 135/85 mm Hg) and hypertensive (BP > 160/90 mm Hg) elderly subjects over 65 years old who were stratified as normal weight (body mass index, BMI, < 27) and obese (BMI > 27). Obese hypertensive individuals demonstrated marked hyperinsulinemia (P < .01) and significantly reduced (P < .05) submaximally stimulated adipocyte 2-deoxyglucose (2-DOG) uptake (abdominal wall fat biopsy). Normal weight hypertensive subjects also demonstrated higher levels of insulinemia and lower insulin-stimulated 2-DOG uptake than nonobese controls. Adipocyte [Ca2+]j levels were elevated in all elderly subjects compared to young individuals (P < .01). Basal and maximally stimulated 2-DOG uptake were similar in all groups. One month of therapy with a calcium channel blocker, 10 mg nitrendipine twice daily, reduced blood pressure in the hypertensive subjects, reduced plasma insulin to control values during an oral glucose tolerance test in obese hypertensive individuals (P < .01), and restored adipocyte 2-DOG uptake at submaximally effective insulin concentration to control values in normal weight and obese hypertensive subjects. |
| doi_str_mv | 10.1093/ajh/5.7.459 |
| format | Article |
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Obese hypertensive individuals demonstrated marked hyperinsulinemia (P < .01) and significantly reduced (P < .05) submaximally stimulated adipocyte 2-deoxyglucose (2-DOG) uptake (abdominal wall fat biopsy). Normal weight hypertensive subjects also demonstrated higher levels of insulinemia and lower insulin-stimulated 2-DOG uptake than nonobese controls. Adipocyte [Ca2+]j levels were elevated in all elderly subjects compared to young individuals (P < .01). Basal and maximally stimulated 2-DOG uptake were similar in all groups. One month of therapy with a calcium channel blocker, 10 mg nitrendipine twice daily, reduced blood pressure in the hypertensive subjects, reduced plasma insulin to control values during an oral glucose tolerance test in obese hypertensive individuals (P < .01), and restored adipocyte 2-DOG uptake at submaximally effective insulin concentration to control values in normal weight and obese hypertensive subjects.]]></description><identifier>ISSN: 0895-7061</identifier><identifier>EISSN: 1941-7225</identifier><identifier>EISSN: 1879-1905</identifier><identifier>DOI: 10.1093/ajh/5.7.459</identifier><identifier>PMID: 1637518</identifier><language>eng</language><publisher>New York, NY: Oxford University Press</publisher><subject>Adipose Tissue - metabolism ; Adipose Tissue - pathology ; Aged ; Aging - metabolism ; Arterial hypertension. Arterial hypotension ; Biological and medical sciences ; Blood and lymphatic vessels ; Blood Glucose - analysis ; Calcium - metabolism ; Cardiology. Vascular system ; Clinical manifestations. Epidemiology. Investigative techniques. Etiology ; Cytosol - metabolism ; cytosolic calcium ; Deoxyglucose - pharmacokinetics ; Glucose Tolerance Test ; Humans ; Hyperinsulinism - complications ; Hypertension ; Hypertension - drug therapy ; Hypertension - metabolism ; Insulin - blood ; Insulin Resistance ; Medical sciences ; Nitrendipine - therapeutic use ; Obesity - complications</subject><ispartof>American journal of hypertension, 1992-07, Vol.5 (7), p.459-464</ispartof><rights>1992 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c351t-1e5f5459b5d23bc7b71063e8193141743ea281d380a739ad6e2b18c59c3ca54a3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27923,27924</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=5432986$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/1637518$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Byyny, Richard L.</creatorcontrib><creatorcontrib>Verde, Mary Lo</creatorcontrib><creatorcontrib>Lloyd, Susan</creatorcontrib><creatorcontrib>Mitchell, Wayne</creatorcontrib><creatorcontrib>Draznin, Boris</creatorcontrib><title>Cytosolic Calcium and Insulin Resistance in Elderly Patients With Essential Hypertension</title><title>American journal of hypertension</title><addtitle>AJH</addtitle><description><![CDATA[We evaluated insulin sensitivity in normotensive (blood pressure, BP, < 135/85 mm Hg) and hypertensive (BP > 160/90 mm Hg) elderly subjects over 65 years old who were stratified as normal weight (body mass index, BMI, < 27) and obese (BMI > 27). Obese hypertensive individuals demonstrated marked hyperinsulinemia (P < .01) and significantly reduced (P < .05) submaximally stimulated adipocyte 2-deoxyglucose (2-DOG) uptake (abdominal wall fat biopsy). Normal weight hypertensive subjects also demonstrated higher levels of insulinemia and lower insulin-stimulated 2-DOG uptake than nonobese controls. Adipocyte [Ca2+]j levels were elevated in all elderly subjects compared to young individuals (P < .01). Basal and maximally stimulated 2-DOG uptake were similar in all groups. One month of therapy with a calcium channel blocker, 10 mg nitrendipine twice daily, reduced blood pressure in the hypertensive subjects, reduced plasma insulin to control values during an oral glucose tolerance test in obese hypertensive individuals (P < .01), and restored adipocyte 2-DOG uptake at submaximally effective insulin concentration to control values in normal weight and obese hypertensive subjects.]]></description><subject>Adipose Tissue - metabolism</subject><subject>Adipose Tissue - pathology</subject><subject>Aged</subject><subject>Aging - metabolism</subject><subject>Arterial hypertension. Arterial hypotension</subject><subject>Biological and medical sciences</subject><subject>Blood and lymphatic vessels</subject><subject>Blood Glucose - analysis</subject><subject>Calcium - metabolism</subject><subject>Cardiology. Vascular system</subject><subject>Clinical manifestations. Epidemiology. Investigative techniques. Etiology</subject><subject>Cytosol - metabolism</subject><subject>cytosolic calcium</subject><subject>Deoxyglucose - pharmacokinetics</subject><subject>Glucose Tolerance Test</subject><subject>Humans</subject><subject>Hyperinsulinism - complications</subject><subject>Hypertension</subject><subject>Hypertension - drug therapy</subject><subject>Hypertension - metabolism</subject><subject>Insulin - blood</subject><subject>Insulin Resistance</subject><subject>Medical sciences</subject><subject>Nitrendipine - therapeutic use</subject><subject>Obesity - complications</subject><issn>0895-7061</issn><issn>1941-7225</issn><issn>1879-1905</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1992</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkMFr2zAUxsXYaNNup50HOoxdhlPJsiTrWEy2FAItJaNhFyHLL1StYqd6Niz__VQS2tPj4_vx8fgR8pWzOWdGXLmnxys51_NKmg9kxk3FC12W8iOZsdrIQjPFz8kF4hNjrFKKn5EzroSWvJ6RTXMYBxxi8LRx0YdpR13f0Zsepxh6eg8YcHS9B5rTInaQ4oHeuTFAPyJ9COMjXSDmEFyky8Me0gg9hqH_TD5tXUT4crqX5M-vxbpZFqvb3zfN9arwQvKx4CC3Mj_eyq4Urdet5kwJqLkRvOK6EuDKmneiZk4L4zoFZctrL40X3snKiUvy47i7T8PLBDjaXUAPMboehgmtFswwZUQGfx5BnwbEBFu7T2Hn0sFyZl892uzRSqttfifT306zU7uD7p09isv991Pv0Lu4TdlRwDdMVqI0tcpYccSyRfj3Vrv0bJXOS3a5-WvNerMSa_1gG_EfC-2KGQ</recordid><startdate>19920701</startdate><enddate>19920701</enddate><creator>Byyny, Richard L.</creator><creator>Verde, Mary Lo</creator><creator>Lloyd, Susan</creator><creator>Mitchell, Wayne</creator><creator>Draznin, Boris</creator><general>Oxford University Press</general><general>Elsevier Science</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19920701</creationdate><title>Cytosolic Calcium and Insulin Resistance in Elderly Patients With Essential Hypertension</title><author>Byyny, Richard L. ; Verde, Mary Lo ; Lloyd, Susan ; Mitchell, Wayne ; Draznin, Boris</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c351t-1e5f5459b5d23bc7b71063e8193141743ea281d380a739ad6e2b18c59c3ca54a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1992</creationdate><topic>Adipose Tissue - metabolism</topic><topic>Adipose Tissue - pathology</topic><topic>Aged</topic><topic>Aging - metabolism</topic><topic>Arterial hypertension. Arterial hypotension</topic><topic>Biological and medical sciences</topic><topic>Blood and lymphatic vessels</topic><topic>Blood Glucose - analysis</topic><topic>Calcium - metabolism</topic><topic>Cardiology. Vascular system</topic><topic>Clinical manifestations. Epidemiology. Investigative techniques. Etiology</topic><topic>Cytosol - metabolism</topic><topic>cytosolic calcium</topic><topic>Deoxyglucose - pharmacokinetics</topic><topic>Glucose Tolerance Test</topic><topic>Humans</topic><topic>Hyperinsulinism - complications</topic><topic>Hypertension</topic><topic>Hypertension - drug therapy</topic><topic>Hypertension - metabolism</topic><topic>Insulin - blood</topic><topic>Insulin Resistance</topic><topic>Medical sciences</topic><topic>Nitrendipine - therapeutic use</topic><topic>Obesity - complications</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Byyny, Richard L.</creatorcontrib><creatorcontrib>Verde, Mary Lo</creatorcontrib><creatorcontrib>Lloyd, Susan</creatorcontrib><creatorcontrib>Mitchell, Wayne</creatorcontrib><creatorcontrib>Draznin, Boris</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>American journal of hypertension</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Byyny, Richard L.</au><au>Verde, Mary Lo</au><au>Lloyd, Susan</au><au>Mitchell, Wayne</au><au>Draznin, Boris</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Cytosolic Calcium and Insulin Resistance in Elderly Patients With Essential Hypertension</atitle><jtitle>American journal of hypertension</jtitle><addtitle>AJH</addtitle><date>1992-07-01</date><risdate>1992</risdate><volume>5</volume><issue>7</issue><spage>459</spage><epage>464</epage><pages>459-464</pages><issn>0895-7061</issn><eissn>1941-7225</eissn><eissn>1879-1905</eissn><abstract><![CDATA[We evaluated insulin sensitivity in normotensive (blood pressure, BP, < 135/85 mm Hg) and hypertensive (BP > 160/90 mm Hg) elderly subjects over 65 years old who were stratified as normal weight (body mass index, BMI, < 27) and obese (BMI > 27). Obese hypertensive individuals demonstrated marked hyperinsulinemia (P < .01) and significantly reduced (P < .05) submaximally stimulated adipocyte 2-deoxyglucose (2-DOG) uptake (abdominal wall fat biopsy). Normal weight hypertensive subjects also demonstrated higher levels of insulinemia and lower insulin-stimulated 2-DOG uptake than nonobese controls. Adipocyte [Ca2+]j levels were elevated in all elderly subjects compared to young individuals (P < .01). Basal and maximally stimulated 2-DOG uptake were similar in all groups. One month of therapy with a calcium channel blocker, 10 mg nitrendipine twice daily, reduced blood pressure in the hypertensive subjects, reduced plasma insulin to control values during an oral glucose tolerance test in obese hypertensive individuals (P < .01), and restored adipocyte 2-DOG uptake at submaximally effective insulin concentration to control values in normal weight and obese hypertensive subjects.]]></abstract><cop>New York, NY</cop><pub>Oxford University Press</pub><pmid>1637518</pmid><doi>10.1093/ajh/5.7.459</doi><tpages>6</tpages></addata></record> |
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| source | MEDLINE; Oxford University Press Journals Digital Archive Legacy |
| subjects | Adipose Tissue - metabolism Adipose Tissue - pathology Aged Aging - metabolism Arterial hypertension. Arterial hypotension Biological and medical sciences Blood and lymphatic vessels Blood Glucose - analysis Calcium - metabolism Cardiology. Vascular system Clinical manifestations. Epidemiology. Investigative techniques. Etiology Cytosol - metabolism cytosolic calcium Deoxyglucose - pharmacokinetics Glucose Tolerance Test Humans Hyperinsulinism - complications Hypertension Hypertension - drug therapy Hypertension - metabolism Insulin - blood Insulin Resistance Medical sciences Nitrendipine - therapeutic use Obesity - complications |
| title | Cytosolic Calcium and Insulin Resistance in Elderly Patients With Essential Hypertension |
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