Dipeptidyl peptidase IV expression in endometrial endometrioid adenocarcinoma and its inverse correlation with tumor grade
Objectives: Dipeptidyl peptidase IV (DPPIV)/CD26 is a cell surface aminopeptidase. This study investigated the expression and localization of DPPIV in endometrial endometrioid adenocarcinomas of different grades. Study Design: Immunohistochemical analysis was performed by using DPPIV and regulated o...
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| Veröffentlicht in: | American journal of obstetrics and gynecology 2003-03, Vol.188 (3), p.670-676 |
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| container_title | American journal of obstetrics and gynecology |
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| creator | Khin, Ei Ei Kikkawa, Fumitaka Ino, Kazuhiko Kajiyama, Hiroaki Suzuki, Takahiro Shibata, Kiyosumi Tamakoshi, Koji Nagasaka, Tetsuro Mizutani, Shigehiko |
| description | Objectives: Dipeptidyl peptidase IV (DPPIV)/CD26 is a cell surface aminopeptidase. This study investigated the expression and localization of DPPIV in endometrial endometrioid adenocarcinomas of different grades. Study Design: Immunohistochemical analysis was performed by using DPPIV and regulated on activation, normal T-cell expressed and secreted (RANTES) specific monoclonal antibodies. Cell proliferation was evaluated by bromodeoxyuridine (BrdU) uptake assay. Results: Immunohistochemical analyses showed that DPPIV was strongly or moderately stained in glandular cells of the normal secretory phase. In endometrial adenocarcinoma, the DPPIV expression decreased with advancing grade (P |
| doi_str_mv | 10.1067/mob.2003.169 |
| format | Article |
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This study investigated the expression and localization of DPPIV in endometrial endometrioid adenocarcinomas of different grades. Study Design: Immunohistochemical analysis was performed by using DPPIV and regulated on activation, normal T-cell expressed and secreted (RANTES) specific monoclonal antibodies. Cell proliferation was evaluated by bromodeoxyuridine (BrdU) uptake assay. Results: Immunohistochemical analyses showed that DPPIV was strongly or moderately stained in glandular cells of the normal secretory phase. In endometrial adenocarcinoma, the DPPIV expression decreased with advancing grade (P <.01). Furthermore, RANTES, one of the possible DPPIV substrates, was highly expressed in all grades of endometrial adenocarcinoma cells. The addition of RANTES to endometrial adenocarcinoma cells increased proliferation in a concentration-dependent manner. Conclusion: DPPIV is expressed in normal endometrial glandular cells, but its expression in endometrial adenocarcinoma is down-regulated with increasing grade. Our data also suggest a regulatory role of this ectoenzyme in neoplastic transformation and progression of endometrial adenocarcinomas possibly by degrading certain bioactive peptides such as RANTES. (Am J Obstet Gynecol 2003;188:670-6.)</description><identifier>ISSN: 0002-9378</identifier><identifier>EISSN: 1097-6868</identifier><identifier>DOI: 10.1067/mob.2003.169</identifier><identifier>PMID: 12634639</identifier><identifier>CODEN: AJOGAH</identifier><language>eng</language><publisher>Philadelphia, PA: Mosby, Inc</publisher><subject>Biological and medical sciences ; Carcinoma, Endometrioid - enzymology ; Carcinoma, Endometrioid - metabolism ; Carcinoma, Endometrioid - pathology ; Cell Division - drug effects ; Cells, Cultured ; Chemokine CCL5 - administration & dosage ; Chemokine CCL5 - metabolism ; Dipeptidyl Peptidase 4 - metabolism ; Dipeptidyl peptidase IV ; Dose-Response Relationship, Drug ; Down-Regulation ; endometrial endometrioid adenocarcinoma ; Endometrial Neoplasms - enzymology ; Endometrial Neoplasms - metabolism ; Endometrial Neoplasms - pathology ; Female ; Female genital diseases ; Gynecology. Andrology. Obstetrics ; Humans ; Immunohistochemistry ; Medical sciences ; Osmolar Concentration ; RANTES ; Tumors</subject><ispartof>American journal of obstetrics and gynecology, 2003-03, Vol.188 (3), p.670-676</ispartof><rights>2003</rights><rights>2003 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c364t-c3ae19a74c7ef85562398c1fb5965d82ad0fb99dbcd0d0f182f6046ed2025b273</citedby><cites>FETCH-LOGICAL-c364t-c3ae19a74c7ef85562398c1fb5965d82ad0fb99dbcd0d0f182f6046ed2025b273</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1067/mob.2003.169$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=14660007$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/12634639$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Khin, Ei Ei</creatorcontrib><creatorcontrib>Kikkawa, Fumitaka</creatorcontrib><creatorcontrib>Ino, Kazuhiko</creatorcontrib><creatorcontrib>Kajiyama, Hiroaki</creatorcontrib><creatorcontrib>Suzuki, Takahiro</creatorcontrib><creatorcontrib>Shibata, Kiyosumi</creatorcontrib><creatorcontrib>Tamakoshi, Koji</creatorcontrib><creatorcontrib>Nagasaka, Tetsuro</creatorcontrib><creatorcontrib>Mizutani, Shigehiko</creatorcontrib><title>Dipeptidyl peptidase IV expression in endometrial endometrioid adenocarcinoma and its inverse correlation with tumor grade</title><title>American journal of obstetrics and gynecology</title><addtitle>Am J Obstet Gynecol</addtitle><description>Objectives: Dipeptidyl peptidase IV (DPPIV)/CD26 is a cell surface aminopeptidase. This study investigated the expression and localization of DPPIV in endometrial endometrioid adenocarcinomas of different grades. Study Design: Immunohistochemical analysis was performed by using DPPIV and regulated on activation, normal T-cell expressed and secreted (RANTES) specific monoclonal antibodies. Cell proliferation was evaluated by bromodeoxyuridine (BrdU) uptake assay. Results: Immunohistochemical analyses showed that DPPIV was strongly or moderately stained in glandular cells of the normal secretory phase. In endometrial adenocarcinoma, the DPPIV expression decreased with advancing grade (P <.01). Furthermore, RANTES, one of the possible DPPIV substrates, was highly expressed in all grades of endometrial adenocarcinoma cells. The addition of RANTES to endometrial adenocarcinoma cells increased proliferation in a concentration-dependent manner. Conclusion: DPPIV is expressed in normal endometrial glandular cells, but its expression in endometrial adenocarcinoma is down-regulated with increasing grade. Our data also suggest a regulatory role of this ectoenzyme in neoplastic transformation and progression of endometrial adenocarcinomas possibly by degrading certain bioactive peptides such as RANTES. (Am J Obstet Gynecol 2003;188:670-6.)</description><subject>Biological and medical sciences</subject><subject>Carcinoma, Endometrioid - enzymology</subject><subject>Carcinoma, Endometrioid - metabolism</subject><subject>Carcinoma, Endometrioid - pathology</subject><subject>Cell Division - drug effects</subject><subject>Cells, Cultured</subject><subject>Chemokine CCL5 - administration & dosage</subject><subject>Chemokine CCL5 - metabolism</subject><subject>Dipeptidyl Peptidase 4 - metabolism</subject><subject>Dipeptidyl peptidase IV</subject><subject>Dose-Response Relationship, Drug</subject><subject>Down-Regulation</subject><subject>endometrial endometrioid adenocarcinoma</subject><subject>Endometrial Neoplasms - enzymology</subject><subject>Endometrial Neoplasms - metabolism</subject><subject>Endometrial Neoplasms - pathology</subject><subject>Female</subject><subject>Female genital diseases</subject><subject>Gynecology. Andrology. Obstetrics</subject><subject>Humans</subject><subject>Immunohistochemistry</subject><subject>Medical sciences</subject><subject>Osmolar Concentration</subject><subject>RANTES</subject><subject>Tumors</subject><issn>0002-9378</issn><issn>1097-6868</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2003</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNptkc9v2yAYhtG0ak3T3XaeuKynJgNsYzhO6U-pUi_drgjD543JBg9I2u6vL1Yi5dILvEjP9-rTA0JfKFlTwtvvY-jWjJBqTbn8gBaUyHbFBRcf0YIQwlayasUpOkvp7_xkkn1Cp5TxquaVXKD_V26CKTv7OuB90Anw_S8ML1OElFzw2HkM3oYRcnR6OObgLNYWfDA6GufDqLH2FrucysgOYikyIUYYdJ5rnl3-g_N2DBH_jmXuHJ30ekjw-XAv0c-b66fN3erh8fZ-8-NhZSpe53JqoFK3tWmhF03DWSWFoX3XSN5YwbQlfSel7YwlJVLBek5qDpYR1nSsrZboYt87xfBvCymr0SUDw6A9hG1SbUUkaYQo4OUeNDGkFKFXU3Sjjq-KEjW7VsW1ml2r4rrgXw-9224Ee4QPcgvw7QDoZPTQR-2NS0eu5rx8ybwg33NQLOwcRJWMA2_AuggmKxvc-xu8Ad01nLA</recordid><startdate>20030301</startdate><enddate>20030301</enddate><creator>Khin, Ei Ei</creator><creator>Kikkawa, Fumitaka</creator><creator>Ino, Kazuhiko</creator><creator>Kajiyama, Hiroaki</creator><creator>Suzuki, Takahiro</creator><creator>Shibata, Kiyosumi</creator><creator>Tamakoshi, Koji</creator><creator>Nagasaka, Tetsuro</creator><creator>Mizutani, Shigehiko</creator><general>Mosby, Inc</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20030301</creationdate><title>Dipeptidyl peptidase IV expression in endometrial endometrioid adenocarcinoma and its inverse correlation with tumor grade</title><author>Khin, Ei Ei ; Kikkawa, Fumitaka ; Ino, Kazuhiko ; Kajiyama, Hiroaki ; Suzuki, Takahiro ; Shibata, Kiyosumi ; Tamakoshi, Koji ; Nagasaka, Tetsuro ; Mizutani, Shigehiko</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c364t-c3ae19a74c7ef85562398c1fb5965d82ad0fb99dbcd0d0f182f6046ed2025b273</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2003</creationdate><topic>Biological and medical sciences</topic><topic>Carcinoma, Endometrioid - enzymology</topic><topic>Carcinoma, Endometrioid - metabolism</topic><topic>Carcinoma, Endometrioid - pathology</topic><topic>Cell Division - drug effects</topic><topic>Cells, Cultured</topic><topic>Chemokine CCL5 - administration & dosage</topic><topic>Chemokine CCL5 - metabolism</topic><topic>Dipeptidyl Peptidase 4 - metabolism</topic><topic>Dipeptidyl peptidase IV</topic><topic>Dose-Response Relationship, Drug</topic><topic>Down-Regulation</topic><topic>endometrial endometrioid adenocarcinoma</topic><topic>Endometrial Neoplasms - enzymology</topic><topic>Endometrial Neoplasms - metabolism</topic><topic>Endometrial Neoplasms - pathology</topic><topic>Female</topic><topic>Female genital diseases</topic><topic>Gynecology. Andrology. Obstetrics</topic><topic>Humans</topic><topic>Immunohistochemistry</topic><topic>Medical sciences</topic><topic>Osmolar Concentration</topic><topic>RANTES</topic><topic>Tumors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Khin, Ei Ei</creatorcontrib><creatorcontrib>Kikkawa, Fumitaka</creatorcontrib><creatorcontrib>Ino, Kazuhiko</creatorcontrib><creatorcontrib>Kajiyama, Hiroaki</creatorcontrib><creatorcontrib>Suzuki, Takahiro</creatorcontrib><creatorcontrib>Shibata, Kiyosumi</creatorcontrib><creatorcontrib>Tamakoshi, Koji</creatorcontrib><creatorcontrib>Nagasaka, Tetsuro</creatorcontrib><creatorcontrib>Mizutani, Shigehiko</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>American journal of obstetrics and gynecology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Khin, Ei Ei</au><au>Kikkawa, Fumitaka</au><au>Ino, Kazuhiko</au><au>Kajiyama, Hiroaki</au><au>Suzuki, Takahiro</au><au>Shibata, Kiyosumi</au><au>Tamakoshi, Koji</au><au>Nagasaka, Tetsuro</au><au>Mizutani, Shigehiko</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Dipeptidyl peptidase IV expression in endometrial endometrioid adenocarcinoma and its inverse correlation with tumor grade</atitle><jtitle>American journal of obstetrics and gynecology</jtitle><addtitle>Am J Obstet Gynecol</addtitle><date>2003-03-01</date><risdate>2003</risdate><volume>188</volume><issue>3</issue><spage>670</spage><epage>676</epage><pages>670-676</pages><issn>0002-9378</issn><eissn>1097-6868</eissn><coden>AJOGAH</coden><abstract>Objectives: Dipeptidyl peptidase IV (DPPIV)/CD26 is a cell surface aminopeptidase. This study investigated the expression and localization of DPPIV in endometrial endometrioid adenocarcinomas of different grades. Study Design: Immunohistochemical analysis was performed by using DPPIV and regulated on activation, normal T-cell expressed and secreted (RANTES) specific monoclonal antibodies. Cell proliferation was evaluated by bromodeoxyuridine (BrdU) uptake assay. Results: Immunohistochemical analyses showed that DPPIV was strongly or moderately stained in glandular cells of the normal secretory phase. In endometrial adenocarcinoma, the DPPIV expression decreased with advancing grade (P <.01). Furthermore, RANTES, one of the possible DPPIV substrates, was highly expressed in all grades of endometrial adenocarcinoma cells. The addition of RANTES to endometrial adenocarcinoma cells increased proliferation in a concentration-dependent manner. Conclusion: DPPIV is expressed in normal endometrial glandular cells, but its expression in endometrial adenocarcinoma is down-regulated with increasing grade. Our data also suggest a regulatory role of this ectoenzyme in neoplastic transformation and progression of endometrial adenocarcinomas possibly by degrading certain bioactive peptides such as RANTES. (Am J Obstet Gynecol 2003;188:670-6.)</abstract><cop>Philadelphia, PA</cop><pub>Mosby, Inc</pub><pmid>12634639</pmid><doi>10.1067/mob.2003.169</doi><tpages>7</tpages></addata></record> |
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| ispartof | American journal of obstetrics and gynecology, 2003-03, Vol.188 (3), p.670-676 |
| issn | 0002-9378 1097-6868 |
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| subjects | Biological and medical sciences Carcinoma, Endometrioid - enzymology Carcinoma, Endometrioid - metabolism Carcinoma, Endometrioid - pathology Cell Division - drug effects Cells, Cultured Chemokine CCL5 - administration & dosage Chemokine CCL5 - metabolism Dipeptidyl Peptidase 4 - metabolism Dipeptidyl peptidase IV Dose-Response Relationship, Drug Down-Regulation endometrial endometrioid adenocarcinoma Endometrial Neoplasms - enzymology Endometrial Neoplasms - metabolism Endometrial Neoplasms - pathology Female Female genital diseases Gynecology. Andrology. Obstetrics Humans Immunohistochemistry Medical sciences Osmolar Concentration RANTES Tumors |
| title | Dipeptidyl peptidase IV expression in endometrial endometrioid adenocarcinoma and its inverse correlation with tumor grade |
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