A prostacyclin analogue reduces free radical generation in heart-lung transplantation
The mechanism by which prostacyclin acts to prevent in vivo reperfusion injury is still uncertain. This study was therefore undertaken to assess the effect of a stable prostacyclin analogue (OP 41483-α-CD [OP]) on oxygen-derived free radicals after heart-lung transplantation. OP was administered to...
Gespeichert in:
| Veröffentlicht in: | The Annals of thoracic surgery 1992-08, Vol.54 (2), p.327-332 |
|---|---|
| Hauptverfasser: | , , , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 332 |
|---|---|
| container_issue | 2 |
| container_start_page | 327 |
| container_title | The Annals of thoracic surgery |
| container_volume | 54 |
| creator | Takeuchi, Koh Suzuki, Sohei Kako, Norio Kobayashi, Makoto Takahashi, Shoichi Sawada, Mitsuhiro Honma, Takemi Iwabuchi, Satoshi Fukui, Kozo Koyama, Koichi Koie, Hisaaki |
| description | The mechanism by which prostacyclin acts to prevent in vivo reperfusion injury is still uncertain. This study was therefore undertaken to assess the effect of a stable prostacyclin analogue (OP 41483-α-CD [OP]) on oxygen-derived free radicals after heart-lung transplantation. OP was administered to the heart-lung graft through the pulmonary artery for 25 minutes encompassing the reperfusion process. Free radicals were directly measured by electron spin resonance spectroscopy. The radical intensities of pulmonary venous blood were significantly lower in the OP group than in the control group, suggesting that fewer free radicals were generated in the lungs of the OP group. The cardiac and respiratory function were better in the OP group than in the control group. The lung is the primary source of oxygen free radical attack, and the beneficial action of OP on free radical generation is almost exclusively restricted to the lung and does not apply to the heart. This result suggested that OP probably is effective in inhibiting free radical generation from the endothelium. |
| doi_str_mv | 10.1016/0003-4975(92)91394-O |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_73090273</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>000349759291394O</els_id><sourcerecordid>73090273</sourcerecordid><originalsourceid>FETCH-LOGICAL-c467t-9621069e347ef6d4557c1669a8a25faa0b11b212b987a156d39d7548d6475e773</originalsourceid><addsrcrecordid>eNp9kE1LAzEQhoMoWj_-gcIeRPSwmmTz0VwEEb-g0Is9h2kyWyPb3ZrsCv57U1v05mkY3meGmYeQU0avGWXqhlJalcJoeWn4lWGVEeV0h4yYlLxUXJpdMvpFDshhSu-55TneJ_us4pwxNSKzu2IVu9SD-3JNaAtooekWAxYR_eAwFXXE3IAPDppigS1G6EPXFpl9Q4h92QztougjtGnVQNv_pMdkr4Ym4cm2HpHZ48Pr_XM5mT693N9NSieU7kujOKPKYCU01soLKbVjShkYA5c1AJ0zNueMz81YA5PKV8ZrKcZeCS1R6-qIXGz25h8-Bky9XYbksMmHYDckqytqKNdVBsUGdPnZFLG2qxiWEL8so3Zt065V2bUqa7j9sWmneexsu3-YL9H_DW305fx8m0PKfupswYX0i0khqRivz7zdYJhdfAaMNrmArUMfIrre-i78f8c3bA2QVA</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>73090273</pqid></control><display><type>article</type><title>A prostacyclin analogue reduces free radical generation in heart-lung transplantation</title><source>MEDLINE</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>Alma/SFX Local Collection</source><creator>Takeuchi, Koh ; Suzuki, Sohei ; Kako, Norio ; Kobayashi, Makoto ; Takahashi, Shoichi ; Sawada, Mitsuhiro ; Honma, Takemi ; Iwabuchi, Satoshi ; Fukui, Kozo ; Koyama, Koichi ; Koie, Hisaaki</creator><creatorcontrib>Takeuchi, Koh ; Suzuki, Sohei ; Kako, Norio ; Kobayashi, Makoto ; Takahashi, Shoichi ; Sawada, Mitsuhiro ; Honma, Takemi ; Iwabuchi, Satoshi ; Fukui, Kozo ; Koyama, Koichi ; Koie, Hisaaki</creatorcontrib><description>The mechanism by which prostacyclin acts to prevent in vivo reperfusion injury is still uncertain. This study was therefore undertaken to assess the effect of a stable prostacyclin analogue (OP 41483-α-CD [OP]) on oxygen-derived free radicals after heart-lung transplantation. OP was administered to the heart-lung graft through the pulmonary artery for 25 minutes encompassing the reperfusion process. Free radicals were directly measured by electron spin resonance spectroscopy. The radical intensities of pulmonary venous blood were significantly lower in the OP group than in the control group, suggesting that fewer free radicals were generated in the lungs of the OP group. The cardiac and respiratory function were better in the OP group than in the control group. The lung is the primary source of oxygen free radical attack, and the beneficial action of OP on free radical generation is almost exclusively restricted to the lung and does not apply to the heart. This result suggested that OP probably is effective in inhibiting free radical generation from the endothelium.</description><identifier>ISSN: 0003-4975</identifier><identifier>EISSN: 1552-6259</identifier><identifier>DOI: 10.1016/0003-4975(92)91394-O</identifier><identifier>PMID: 1322116</identifier><identifier>CODEN: ATHSAK</identifier><language>eng</language><publisher>New York, NY: Elsevier Inc</publisher><subject>Adenosine Diphosphate - metabolism ; Adenosine Monophosphate - metabolism ; Adenosine Triphosphate - metabolism ; alpha-Cyclodextrins ; Animals ; Biological and medical sciences ; Cyclodextrins - pharmacology ; Dogs ; Electron Spin Resonance Spectroscopy ; Epoprostenol - analogs & derivatives ; Epoprostenol - pharmacology ; Free Radicals ; Heart-Lung Transplantation ; Hemodynamics ; Medical sciences ; Miscellaneous ; Myocardium - metabolism ; Pharmacology. Drug treatments</subject><ispartof>The Annals of thoracic surgery, 1992-08, Vol.54 (2), p.327-332</ispartof><rights>1992 The Society of Thoracic Surgeons</rights><rights>1992 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c467t-9621069e347ef6d4557c1669a8a25faa0b11b212b987a156d39d7548d6475e773</citedby><cites>FETCH-LOGICAL-c467t-9621069e347ef6d4557c1669a8a25faa0b11b212b987a156d39d7548d6475e773</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=5450487$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/1322116$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Takeuchi, Koh</creatorcontrib><creatorcontrib>Suzuki, Sohei</creatorcontrib><creatorcontrib>Kako, Norio</creatorcontrib><creatorcontrib>Kobayashi, Makoto</creatorcontrib><creatorcontrib>Takahashi, Shoichi</creatorcontrib><creatorcontrib>Sawada, Mitsuhiro</creatorcontrib><creatorcontrib>Honma, Takemi</creatorcontrib><creatorcontrib>Iwabuchi, Satoshi</creatorcontrib><creatorcontrib>Fukui, Kozo</creatorcontrib><creatorcontrib>Koyama, Koichi</creatorcontrib><creatorcontrib>Koie, Hisaaki</creatorcontrib><title>A prostacyclin analogue reduces free radical generation in heart-lung transplantation</title><title>The Annals of thoracic surgery</title><addtitle>Ann Thorac Surg</addtitle><description>The mechanism by which prostacyclin acts to prevent in vivo reperfusion injury is still uncertain. This study was therefore undertaken to assess the effect of a stable prostacyclin analogue (OP 41483-α-CD [OP]) on oxygen-derived free radicals after heart-lung transplantation. OP was administered to the heart-lung graft through the pulmonary artery for 25 minutes encompassing the reperfusion process. Free radicals were directly measured by electron spin resonance spectroscopy. The radical intensities of pulmonary venous blood were significantly lower in the OP group than in the control group, suggesting that fewer free radicals were generated in the lungs of the OP group. The cardiac and respiratory function were better in the OP group than in the control group. The lung is the primary source of oxygen free radical attack, and the beneficial action of OP on free radical generation is almost exclusively restricted to the lung and does not apply to the heart. This result suggested that OP probably is effective in inhibiting free radical generation from the endothelium.</description><subject>Adenosine Diphosphate - metabolism</subject><subject>Adenosine Monophosphate - metabolism</subject><subject>Adenosine Triphosphate - metabolism</subject><subject>alpha-Cyclodextrins</subject><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Cyclodextrins - pharmacology</subject><subject>Dogs</subject><subject>Electron Spin Resonance Spectroscopy</subject><subject>Epoprostenol - analogs & derivatives</subject><subject>Epoprostenol - pharmacology</subject><subject>Free Radicals</subject><subject>Heart-Lung Transplantation</subject><subject>Hemodynamics</subject><subject>Medical sciences</subject><subject>Miscellaneous</subject><subject>Myocardium - metabolism</subject><subject>Pharmacology. Drug treatments</subject><issn>0003-4975</issn><issn>1552-6259</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1992</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kE1LAzEQhoMoWj_-gcIeRPSwmmTz0VwEEb-g0Is9h2kyWyPb3ZrsCv57U1v05mkY3meGmYeQU0avGWXqhlJalcJoeWn4lWGVEeV0h4yYlLxUXJpdMvpFDshhSu-55TneJ_us4pwxNSKzu2IVu9SD-3JNaAtooekWAxYR_eAwFXXE3IAPDppigS1G6EPXFpl9Q4h92QztougjtGnVQNv_pMdkr4Ym4cm2HpHZ48Pr_XM5mT693N9NSieU7kujOKPKYCU01soLKbVjShkYA5c1AJ0zNueMz81YA5PKV8ZrKcZeCS1R6-qIXGz25h8-Bky9XYbksMmHYDckqytqKNdVBsUGdPnZFLG2qxiWEL8so3Zt065V2bUqa7j9sWmneexsu3-YL9H_DW305fx8m0PKfupswYX0i0khqRivz7zdYJhdfAaMNrmArUMfIrre-i78f8c3bA2QVA</recordid><startdate>19920801</startdate><enddate>19920801</enddate><creator>Takeuchi, Koh</creator><creator>Suzuki, Sohei</creator><creator>Kako, Norio</creator><creator>Kobayashi, Makoto</creator><creator>Takahashi, Shoichi</creator><creator>Sawada, Mitsuhiro</creator><creator>Honma, Takemi</creator><creator>Iwabuchi, Satoshi</creator><creator>Fukui, Kozo</creator><creator>Koyama, Koichi</creator><creator>Koie, Hisaaki</creator><general>Elsevier Inc</general><general>Elsevier Science</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19920801</creationdate><title>A prostacyclin analogue reduces free radical generation in heart-lung transplantation</title><author>Takeuchi, Koh ; Suzuki, Sohei ; Kako, Norio ; Kobayashi, Makoto ; Takahashi, Shoichi ; Sawada, Mitsuhiro ; Honma, Takemi ; Iwabuchi, Satoshi ; Fukui, Kozo ; Koyama, Koichi ; Koie, Hisaaki</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c467t-9621069e347ef6d4557c1669a8a25faa0b11b212b987a156d39d7548d6475e773</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1992</creationdate><topic>Adenosine Diphosphate - metabolism</topic><topic>Adenosine Monophosphate - metabolism</topic><topic>Adenosine Triphosphate - metabolism</topic><topic>alpha-Cyclodextrins</topic><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Cyclodextrins - pharmacology</topic><topic>Dogs</topic><topic>Electron Spin Resonance Spectroscopy</topic><topic>Epoprostenol - analogs & derivatives</topic><topic>Epoprostenol - pharmacology</topic><topic>Free Radicals</topic><topic>Heart-Lung Transplantation</topic><topic>Hemodynamics</topic><topic>Medical sciences</topic><topic>Miscellaneous</topic><topic>Myocardium - metabolism</topic><topic>Pharmacology. Drug treatments</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Takeuchi, Koh</creatorcontrib><creatorcontrib>Suzuki, Sohei</creatorcontrib><creatorcontrib>Kako, Norio</creatorcontrib><creatorcontrib>Kobayashi, Makoto</creatorcontrib><creatorcontrib>Takahashi, Shoichi</creatorcontrib><creatorcontrib>Sawada, Mitsuhiro</creatorcontrib><creatorcontrib>Honma, Takemi</creatorcontrib><creatorcontrib>Iwabuchi, Satoshi</creatorcontrib><creatorcontrib>Fukui, Kozo</creatorcontrib><creatorcontrib>Koyama, Koichi</creatorcontrib><creatorcontrib>Koie, Hisaaki</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>The Annals of thoracic surgery</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Takeuchi, Koh</au><au>Suzuki, Sohei</au><au>Kako, Norio</au><au>Kobayashi, Makoto</au><au>Takahashi, Shoichi</au><au>Sawada, Mitsuhiro</au><au>Honma, Takemi</au><au>Iwabuchi, Satoshi</au><au>Fukui, Kozo</au><au>Koyama, Koichi</au><au>Koie, Hisaaki</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A prostacyclin analogue reduces free radical generation in heart-lung transplantation</atitle><jtitle>The Annals of thoracic surgery</jtitle><addtitle>Ann Thorac Surg</addtitle><date>1992-08-01</date><risdate>1992</risdate><volume>54</volume><issue>2</issue><spage>327</spage><epage>332</epage><pages>327-332</pages><issn>0003-4975</issn><eissn>1552-6259</eissn><coden>ATHSAK</coden><abstract>The mechanism by which prostacyclin acts to prevent in vivo reperfusion injury is still uncertain. This study was therefore undertaken to assess the effect of a stable prostacyclin analogue (OP 41483-α-CD [OP]) on oxygen-derived free radicals after heart-lung transplantation. OP was administered to the heart-lung graft through the pulmonary artery for 25 minutes encompassing the reperfusion process. Free radicals were directly measured by electron spin resonance spectroscopy. The radical intensities of pulmonary venous blood were significantly lower in the OP group than in the control group, suggesting that fewer free radicals were generated in the lungs of the OP group. The cardiac and respiratory function were better in the OP group than in the control group. The lung is the primary source of oxygen free radical attack, and the beneficial action of OP on free radical generation is almost exclusively restricted to the lung and does not apply to the heart. This result suggested that OP probably is effective in inhibiting free radical generation from the endothelium.</abstract><cop>New York, NY</cop><pub>Elsevier Inc</pub><pmid>1322116</pmid><doi>10.1016/0003-4975(92)91394-O</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0003-4975 |
| ispartof | The Annals of thoracic surgery, 1992-08, Vol.54 (2), p.327-332 |
| issn | 0003-4975 1552-6259 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_73090273 |
| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Alma/SFX Local Collection |
| subjects | Adenosine Diphosphate - metabolism Adenosine Monophosphate - metabolism Adenosine Triphosphate - metabolism alpha-Cyclodextrins Animals Biological and medical sciences Cyclodextrins - pharmacology Dogs Electron Spin Resonance Spectroscopy Epoprostenol - analogs & derivatives Epoprostenol - pharmacology Free Radicals Heart-Lung Transplantation Hemodynamics Medical sciences Miscellaneous Myocardium - metabolism Pharmacology. Drug treatments |
| title | A prostacyclin analogue reduces free radical generation in heart-lung transplantation |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-15T05%3A26%3A43IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=A%20prostacyclin%20analogue%20reduces%20free%20radical%20generation%20in%20heart-lung%20transplantation&rft.jtitle=The%20Annals%20of%20thoracic%20surgery&rft.au=Takeuchi,%20Koh&rft.date=1992-08-01&rft.volume=54&rft.issue=2&rft.spage=327&rft.epage=332&rft.pages=327-332&rft.issn=0003-4975&rft.eissn=1552-6259&rft.coden=ATHSAK&rft_id=info:doi/10.1016/0003-4975(92)91394-O&rft_dat=%3Cproquest_cross%3E73090273%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=73090273&rft_id=info:pmid/1322116&rft_els_id=000349759291394O&rfr_iscdi=true |