The role of NMDA glutamate receptors, PKA, MAPK, and CAMKII in the hippocampus in extinction of conditioned fear

Pavlovian conditioning involves the association of initially neutral conditioned stimuli (CS) with unconditioned stimuli (US) that elicit a response. In contextual fear conditioning in rodents, the CS is the context of a training apparatus and the US is a foot shock. Retrieval of memory of the train...

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Veröffentlicht in:Hippocampus 2003, Vol.13 (1), p.53-58
Hauptverfasser: Szapiro, German, Vianna, Monica R.M., McGaugh, James L., Medina, Jorge H., Izquierdo, Ivan
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container_issue 1
container_start_page 53
container_title Hippocampus
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creator Szapiro, German
Vianna, Monica R.M.
McGaugh, James L.
Medina, Jorge H.
Izquierdo, Ivan
description Pavlovian conditioning involves the association of initially neutral conditioned stimuli (CS) with unconditioned stimuli (US) that elicit a response. In contextual fear conditioning in rodents, the CS is the context of a training apparatus and the US is a foot shock. Retrieval of memory of the training is tested by presenting the CS alone. But a retrieval test also initiates extinction of the conditioned response. That is, presentation of the CS alone results in new learning, i.e., the CS no longer predicts the US. Here we report that extinction is triggered by two hippocampal signaling pathways underlying retrieval (the cAMP‐dependent protein kinase and the mitogen‐activated protein kinase pathways) and two other mechanisms that become activated at the same time and are not necessary for retrieval (N‐methyl‐D‐aspartate glutamatergic receptors and the calcium/calmodulin‐dependent protein kinase II signaling pathway). Thus, the molecular mechanisms underlying acquisition and/or consolidation of the memory for extinction are similar to those described for the acquisition and/or consolidation of the original contextual fear. Hippocampus 2003;13:53–58. © 2003 Wiley‐Liss, Inc.
doi_str_mv 10.1002/hipo.10043
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inhibitors</subject><subject>Receptors, N-Methyl-D-Aspartate - metabolism</subject><subject>Synapses - drug effects</subject><subject>Synapses - metabolism</subject><subject>Synaptic Transmission - drug effects</subject><subject>Synaptic Transmission - physiology</subject><issn>1050-9631</issn><issn>1098-1063</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2003</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kE9v1DAQxS1ERUvphQ-AfOKANmUcO3FyTLfQrna33cNWHC3Hf6ghiYOdiPbbk7AL3DjNzNPvvZEeQm8JXBKA9OOj6_28MfoCnREoi4RATl_OewZJmVNyil7H-A2AkAzgFTolaZ5mLONnqN8_Ghx8Y7C3-G57XeGvzTjIVg6TbJTpBx_iAu_W1QJvq916gWWn8bLarlcr7Do8TPbpf--VbPsxzpJ5GlynBue7OVP5Trv5MBpbI8MbdGJlE83FcZ6jh8-f9svbZHN_s1pWm0SxtKRJrSnnnGW6yIkEq5nOJIM6t0BqpmkxzZRyxi1Tup7kAjinNrVEp1CkRNFz9P6Q2wf_YzRxEK2LyjSN7Iwfo-AUSoCcTeCHA6iCjzEYK_rgWhmeBQEx9yvmfsXvfif43TF1rFuj_6HHQieAHICfrjHP_4kSt6vd_Z_Q5OBxcTBPfz0yfBc5pzwTX-5uRMk25dXymoo9_QVC7pJp</recordid><startdate>2003</startdate><enddate>2003</enddate><creator>Szapiro, German</creator><creator>Vianna, Monica R.M.</creator><creator>McGaugh, James L.</creator><creator>Medina, Jorge H.</creator><creator>Izquierdo, Ivan</creator><general>Wiley Subscription Services, Inc., A Wiley Company</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>2003</creationdate><title>The role of NMDA glutamate receptors, PKA, MAPK, and CAMKII in the hippocampus in extinction of conditioned fear</title><author>Szapiro, German ; 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subjects Animals
avoidance training
CA1 region
Calcium-Calmodulin-Dependent Protein Kinase Type 2
Calcium-Calmodulin-Dependent Protein Kinases - antagonists & inhibitors
Calcium-Calmodulin-Dependent Protein Kinases - metabolism
Conditioning (Psychology) - drug effects
Conditioning (Psychology) - physiology
Cyclic AMP-Dependent Protein Kinases - antagonists & inhibitors
Cyclic AMP-Dependent Protein Kinases - metabolism
Enzyme Inhibitors - pharmacology
Excitatory Amino Acid Antagonists - pharmacology
Extinction, Psychological - drug effects
Extinction, Psychological - physiology
Fear - drug effects
Fear - physiology
Hippocampus - drug effects
Hippocampus - metabolism
Learning - drug effects
Learning - physiology
Male
MAP Kinase Signaling System - drug effects
MAP Kinase Signaling System - physiology
Memory - drug effects
Memory - physiology
memory consolidation
memory retrieval
protein kinases
Rats
Rats, Wistar
Receptors, N-Methyl-D-Aspartate - antagonists & inhibitors
Receptors, N-Methyl-D-Aspartate - metabolism
Synapses - drug effects
Synapses - metabolism
Synaptic Transmission - drug effects
Synaptic Transmission - physiology
title The role of NMDA glutamate receptors, PKA, MAPK, and CAMKII in the hippocampus in extinction of conditioned fear
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