Molecular structure and genetic stability of human hypoxanthine phosphoribosyltransferase ( HPRT) gene duplications

We have determined the genetic stability of three independent intragenic human HPRT gene duplications and the structure of each duplication at the nucleotide sequence level. Two of the duplications were isolated as spontaneous mutations from the HL60 human myeloid leukemia cell line, while the third...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Genomics (San Diego, Calif.) Calif.), 1992-07, Vol.13 (3), p.788-796
Hauptverfasser:	Monnat, Raymond J., Chiaverotti, Teresa A., Hackmann, Alden F.M., Maresh, Grace A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Base Sequence Biological and medical sciences Classical genetics, quantitative genetics, hybrids DNA - genetics DNA Mutational Analysis duplication Fundamental and applied biological sciences. Psychology genes Genetics of eukaryotes. Biological and molecular evolution Human Humans hypoxanthine phosphoribosyltransferase Hypoxanthine Phosphoribosyltransferase - genetics Lesch-Nyhan syndrome Lesch-Nyhan Syndrome - enzymology Lesch-Nyhan Syndrome - genetics man Models, Genetic Molecular Sequence Data Multigene Family RNA, Messenger - genetics stability Tumor Cells, Cultured - enzymology
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!