Plasma plasminogen activator inhibitor activity and tissue plasminogen activator levels in patients with unstable angina and those with coronary spastic angina
Plasminogen activator inhibitor (PAI) activity and tissue plasminogen activator (TPA) antigen were measured in venous samples in 14 patients with unstable angina consisting of eight patients with organic stenosed coronary arteries and six patients with coronary spastic angina (unstable angina group)...
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| Veröffentlicht in: | The American heart journal 1992-08, Vol.124 (2), p.314-319 |
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| container_title | The American heart journal |
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| creator | Masuda, Takenobu Yasue, Hirofumi Ogawa, Hisao Misumi, Ikuo Sakamoto, Tomohiro Okubo, Hiroto Miyao, Yuji Kato, Hideji |
| description | Plasminogen activator inhibitor (PAI) activity and tissue plasminogen activator (TPA) antigen were measured in venous samples in 14 patients with unstable angina consisting of eight patients with organic stenosed coronary arteries and six patients with coronary spastic angina (unstable angina group); in 14 patients with stable exertional angina (stable exertional angina group); and in 14 patients with chest pain syndrome (chest pain syndrome group). The plasma levels of PAI activity were higher (
p < 0.01) in the unstable angina group than in the stable exertional angina group and the chest pain syndrome group (12.3 ± 1.0 versus 5.1 ± 0.7 and 4.8 ± 0.6 IU/ml). The plasma levels of TPA antigen were also higher (
p < 0.05) in the unstable angina group than in the stable exertional angina group and the chest pain syndrome group (10.2 ± 1.3 versus 6.5 ± 0.8 and 6.0 ± 0.7 ng/ml). There were no significant differences in PAI activity and TPA antigen levels between the stable exertional angina group and the chest pain syndrome group. Furthermore, both PAI activity and TPA antigen levels in the unstable angina group decreased to the levels in the stable exertional angina group and the chest pain syndrome group after treatment (
p < 0.01). In conclusion, the increased plasma PAI activity in patients with unstable angina and in those with coronary spastic angina indicates that the fibrinolytic system is impaired in these patients. |
| doi_str_mv | 10.1016/0002-8703(92)90592-J |
| format | Article |
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p < 0.01) in the unstable angina group than in the stable exertional angina group and the chest pain syndrome group (12.3 ± 1.0 versus 5.1 ± 0.7 and 4.8 ± 0.6 IU/ml). The plasma levels of TPA antigen were also higher (
p < 0.05) in the unstable angina group than in the stable exertional angina group and the chest pain syndrome group (10.2 ± 1.3 versus 6.5 ± 0.8 and 6.0 ± 0.7 ng/ml). There were no significant differences in PAI activity and TPA antigen levels between the stable exertional angina group and the chest pain syndrome group. Furthermore, both PAI activity and TPA antigen levels in the unstable angina group decreased to the levels in the stable exertional angina group and the chest pain syndrome group after treatment (
p < 0.01). In conclusion, the increased plasma PAI activity in patients with unstable angina and in those with coronary spastic angina indicates that the fibrinolytic system is impaired in these patients.</description><identifier>ISSN: 0002-8703</identifier><identifier>EISSN: 1097-6744</identifier><identifier>DOI: 10.1016/0002-8703(92)90592-J</identifier><identifier>PMID: 1636575</identifier><language>eng</language><publisher>United States: Mosby, Inc</publisher><subject>Angina, Unstable - blood ; Chest Pain - blood ; Coronary Angiography ; Coronary Vasospasm - blood ; Enzyme-Linked Immunosorbent Assay ; Female ; Fibrinolysis - physiology ; Humans ; Male ; Middle Aged ; Plasminogen Inactivators - metabolism ; Syndrome ; Tissue Plasminogen Activator - metabolism</subject><ispartof>The American heart journal, 1992-08, Vol.124 (2), p.314-319</ispartof><rights>1992</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c357t-b626a066ac02f4caecb59e72aaf4d1821909e8936ba66d7ca5796ed218df63da3</citedby><cites>FETCH-LOGICAL-c357t-b626a066ac02f4caecb59e72aaf4d1821909e8936ba66d7ca5796ed218df63da3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/0002-8703(92)90592-J$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3536,27903,27904,45974</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/1636575$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Masuda, Takenobu</creatorcontrib><creatorcontrib>Yasue, Hirofumi</creatorcontrib><creatorcontrib>Ogawa, Hisao</creatorcontrib><creatorcontrib>Misumi, Ikuo</creatorcontrib><creatorcontrib>Sakamoto, Tomohiro</creatorcontrib><creatorcontrib>Okubo, Hiroto</creatorcontrib><creatorcontrib>Miyao, Yuji</creatorcontrib><creatorcontrib>Kato, Hideji</creatorcontrib><title>Plasma plasminogen activator inhibitor activity and tissue plasminogen activator levels in patients with unstable angina and those with coronary spastic angina</title><title>The American heart journal</title><addtitle>Am Heart J</addtitle><description>Plasminogen activator inhibitor (PAI) activity and tissue plasminogen activator (TPA) antigen were measured in venous samples in 14 patients with unstable angina consisting of eight patients with organic stenosed coronary arteries and six patients with coronary spastic angina (unstable angina group); in 14 patients with stable exertional angina (stable exertional angina group); and in 14 patients with chest pain syndrome (chest pain syndrome group). The plasma levels of PAI activity were higher (
p < 0.01) in the unstable angina group than in the stable exertional angina group and the chest pain syndrome group (12.3 ± 1.0 versus 5.1 ± 0.7 and 4.8 ± 0.6 IU/ml). The plasma levels of TPA antigen were also higher (
p < 0.05) in the unstable angina group than in the stable exertional angina group and the chest pain syndrome group (10.2 ± 1.3 versus 6.5 ± 0.8 and 6.0 ± 0.7 ng/ml). There were no significant differences in PAI activity and TPA antigen levels between the stable exertional angina group and the chest pain syndrome group. Furthermore, both PAI activity and TPA antigen levels in the unstable angina group decreased to the levels in the stable exertional angina group and the chest pain syndrome group after treatment (
p < 0.01). In conclusion, the increased plasma PAI activity in patients with unstable angina and in those with coronary spastic angina indicates that the fibrinolytic system is impaired in these patients.</description><subject>Angina, Unstable - blood</subject><subject>Chest Pain - blood</subject><subject>Coronary Angiography</subject><subject>Coronary Vasospasm - blood</subject><subject>Enzyme-Linked Immunosorbent Assay</subject><subject>Female</subject><subject>Fibrinolysis - physiology</subject><subject>Humans</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Plasminogen Inactivators - metabolism</subject><subject>Syndrome</subject><subject>Tissue Plasminogen Activator - metabolism</subject><issn>0002-8703</issn><issn>1097-6744</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1992</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9UU2P1SAUJUYzvhn9B5qwMrqoAm2hbEzMREcnk-hC1-QWbudh-qACfWZ-jX_VdvqiK11d4Hxccg4hzzh7zRmXbxhjouoUq19q8UqzVovq-gHZcaZVJVXTPCS7P5TH5Dzn78tVik6ekTMua9mqdkd-fRkhH4BO6_Ah3mKgYIs_QomJ-rD3vV9P92--3FEIjhaf84z_0Ix4xDEvUjpB8RhKpj992dM55AL9iIvDrQ-wGe1jxg22McUA6Y7mCXLx9kR7Qh4NMGZ8epoX5NuH918vP1Y3n68-Xb67qWzdqlL1UkhgUoJlYmgsoO1bjUoADI3jneCaaex0LXuQ0ikLrdISneCdG2TtoL4gLzbfKcUfM-ZiDj5bHEcIGOdsVM06LWq-EJuNaFPMOeFgpuQPy8cNZ2btxayhmzV0o4W578VcL7LnJ_-5P6D7K9qKWPC3G75kh0ePyWS7hGfR-YS2GBf9_xf8BveFoh4</recordid><startdate>19920801</startdate><enddate>19920801</enddate><creator>Masuda, Takenobu</creator><creator>Yasue, Hirofumi</creator><creator>Ogawa, Hisao</creator><creator>Misumi, Ikuo</creator><creator>Sakamoto, Tomohiro</creator><creator>Okubo, Hiroto</creator><creator>Miyao, Yuji</creator><creator>Kato, Hideji</creator><general>Mosby, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19920801</creationdate><title>Plasma plasminogen activator inhibitor activity and tissue plasminogen activator levels in patients with unstable angina and those with coronary spastic angina</title><author>Masuda, Takenobu ; Yasue, Hirofumi ; Ogawa, Hisao ; Misumi, Ikuo ; Sakamoto, Tomohiro ; Okubo, Hiroto ; Miyao, Yuji ; Kato, Hideji</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c357t-b626a066ac02f4caecb59e72aaf4d1821909e8936ba66d7ca5796ed218df63da3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1992</creationdate><topic>Angina, Unstable - blood</topic><topic>Chest Pain - blood</topic><topic>Coronary Angiography</topic><topic>Coronary Vasospasm - blood</topic><topic>Enzyme-Linked Immunosorbent Assay</topic><topic>Female</topic><topic>Fibrinolysis - physiology</topic><topic>Humans</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Plasminogen Inactivators - metabolism</topic><topic>Syndrome</topic><topic>Tissue Plasminogen Activator - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Masuda, Takenobu</creatorcontrib><creatorcontrib>Yasue, Hirofumi</creatorcontrib><creatorcontrib>Ogawa, Hisao</creatorcontrib><creatorcontrib>Misumi, Ikuo</creatorcontrib><creatorcontrib>Sakamoto, Tomohiro</creatorcontrib><creatorcontrib>Okubo, Hiroto</creatorcontrib><creatorcontrib>Miyao, Yuji</creatorcontrib><creatorcontrib>Kato, Hideji</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>The American heart journal</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Masuda, Takenobu</au><au>Yasue, Hirofumi</au><au>Ogawa, Hisao</au><au>Misumi, Ikuo</au><au>Sakamoto, Tomohiro</au><au>Okubo, Hiroto</au><au>Miyao, Yuji</au><au>Kato, Hideji</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Plasma plasminogen activator inhibitor activity and tissue plasminogen activator levels in patients with unstable angina and those with coronary spastic angina</atitle><jtitle>The American heart journal</jtitle><addtitle>Am Heart J</addtitle><date>1992-08-01</date><risdate>1992</risdate><volume>124</volume><issue>2</issue><spage>314</spage><epage>319</epage><pages>314-319</pages><issn>0002-8703</issn><eissn>1097-6744</eissn><abstract>Plasminogen activator inhibitor (PAI) activity and tissue plasminogen activator (TPA) antigen were measured in venous samples in 14 patients with unstable angina consisting of eight patients with organic stenosed coronary arteries and six patients with coronary spastic angina (unstable angina group); in 14 patients with stable exertional angina (stable exertional angina group); and in 14 patients with chest pain syndrome (chest pain syndrome group). The plasma levels of PAI activity were higher (
p < 0.01) in the unstable angina group than in the stable exertional angina group and the chest pain syndrome group (12.3 ± 1.0 versus 5.1 ± 0.7 and 4.8 ± 0.6 IU/ml). The plasma levels of TPA antigen were also higher (
p < 0.05) in the unstable angina group than in the stable exertional angina group and the chest pain syndrome group (10.2 ± 1.3 versus 6.5 ± 0.8 and 6.0 ± 0.7 ng/ml). There were no significant differences in PAI activity and TPA antigen levels between the stable exertional angina group and the chest pain syndrome group. Furthermore, both PAI activity and TPA antigen levels in the unstable angina group decreased to the levels in the stable exertional angina group and the chest pain syndrome group after treatment (
p < 0.01). In conclusion, the increased plasma PAI activity in patients with unstable angina and in those with coronary spastic angina indicates that the fibrinolytic system is impaired in these patients.</abstract><cop>United States</cop><pub>Mosby, Inc</pub><pmid>1636575</pmid><doi>10.1016/0002-8703(92)90592-J</doi><tpages>6</tpages></addata></record> |
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| ispartof | The American heart journal, 1992-08, Vol.124 (2), p.314-319 |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Angina, Unstable - blood Chest Pain - blood Coronary Angiography Coronary Vasospasm - blood Enzyme-Linked Immunosorbent Assay Female Fibrinolysis - physiology Humans Male Middle Aged Plasminogen Inactivators - metabolism Syndrome Tissue Plasminogen Activator - metabolism |
| title | Plasma plasminogen activator inhibitor activity and tissue plasminogen activator levels in patients with unstable angina and those with coronary spastic angina |
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