Comparative study of the lubricant performance of Compritol ® HD5 ATO and Compritol ® 888 ATO: effect of polyethylene glycol behenate on lubricant capacity
The aim of this paper is to study the lubricant capacity of Compritol HD5 ATO, a glyceryl and polyethylene glycol dibehenate, obtained by atomization. This material is compared to Compritol 888 ATO, constituted only by glyceryl dibehenate. First, this study verifies that Compritol HD5 ATO and Compri...
Gespeichert in:
| Veröffentlicht in: | International journal of pharmaceutics 2003-03, Vol.254 (2), p.263-269 |
|---|---|
| Hauptverfasser: | , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 269 |
|---|---|
| container_issue | 2 |
| container_start_page | 263 |
| container_title | International journal of pharmaceutics |
| container_volume | 254 |
| creator | N’Diaye, A. Jannin, V. Bérard, V. Andrès, C. Pourcelot, Y. |
| description | The aim of this paper is to study the lubricant capacity of Compritol HD5 ATO, a glyceryl and polyethylene glycol dibehenate, obtained by atomization. This material is compared to Compritol 888 ATO, constituted only by glyceryl dibehenate. First, this study verifies that Compritol HD5 ATO and Compritol 888 ATO present the same granular characteristics and that their mixes with Lactopress present no structural differences. Secondly, in term of compressibility and cohesiveness, the use of Compritol 888 ATO or Compritol HD5 ATO with Lactopress does not involve any significant modification. Finally, the minor difference of lubricant capacity between Compritol HD5 ATO and Compritol 888 ATO has no consequence in compression practice. The presence of polyethylene glycol behenate does not decrease the glyceryl dibehenate compression functionality. This study concludes that Compritol HD5 ATO could be a very interesting excipient because it associates the glyceryl dibehenate lubricant capacity with the polyethylene glycol behenate-specific capacity in terms of dissolution enhancement. |
| doi_str_mv | 10.1016/S0378-5173(03)00027-9 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_73088871</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0378517303000279</els_id><sourcerecordid>73088871</sourcerecordid><originalsourceid>FETCH-LOGICAL-c391t-a0c15cfe60093fa56440d87baae027dca172bf10e6a558e4c0c9e7788a0868e3</originalsourceid><addsrcrecordid>eNqFkUuO1DAURS0EoouGJYA8AcEgYMeJ7fQEtYpPI7XUA2puvTjPlFE-he20lMWwBRbBynCoEg0jJEsevHPf515CnnL2mjMu33xmQumi5kq8ZOIVY6xURXOPbLhWohCVkvfJ5g9yRh7F-DVDsuTiITnjpSxFycoN-b6dhgMESP4WaUxzt9DJ0bRH2s9t8BbGRA8Y3BQGGC2uxVURfJp6-vMHvXpX08vdDYWx-7egtV4LFxSdQ5tW4WHqF0z7pccR6Zd-sZlscY8jpNx4_GuihQNYn5bH5IGDPuKT039Odh_e77ZXxfXNx0_by-vCioanApjltXUoGWuEg1pWFeu0agEw29JZ4KpsHWcooa41VpbZBpXSGpiWGsU5eXFsewjTtxljMoOPFvseRpzmaJRg-RzFM1gfQRumGAM6kw8eICyGM7PGYn7HYlbPDctvjcU0WffsNGBuB-zuVKccMvD8BEC00LuQzfbxjquk5A2rM_f2yGF249ZjMNF6zMF0PmSXTTf5_6zyC9GorB0</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>73088871</pqid></control><display><type>article</type><title>Comparative study of the lubricant performance of Compritol ® HD5 ATO and Compritol ® 888 ATO: effect of polyethylene glycol behenate on lubricant capacity</title><source>MEDLINE</source><source>Elsevier ScienceDirect Journals</source><creator>N’Diaye, A. ; Jannin, V. ; Bérard, V. ; Andrès, C. ; Pourcelot, Y.</creator><creatorcontrib>N’Diaye, A. ; Jannin, V. ; Bérard, V. ; Andrès, C. ; Pourcelot, Y.</creatorcontrib><description>The aim of this paper is to study the lubricant capacity of Compritol HD5 ATO, a glyceryl and polyethylene glycol dibehenate, obtained by atomization. This material is compared to Compritol 888 ATO, constituted only by glyceryl dibehenate. First, this study verifies that Compritol HD5 ATO and Compritol 888 ATO present the same granular characteristics and that their mixes with Lactopress present no structural differences. Secondly, in term of compressibility and cohesiveness, the use of Compritol 888 ATO or Compritol HD5 ATO with Lactopress does not involve any significant modification. Finally, the minor difference of lubricant capacity between Compritol HD5 ATO and Compritol 888 ATO has no consequence in compression practice. The presence of polyethylene glycol behenate does not decrease the glyceryl dibehenate compression functionality. This study concludes that Compritol HD5 ATO could be a very interesting excipient because it associates the glyceryl dibehenate lubricant capacity with the polyethylene glycol behenate-specific capacity in terms of dissolution enhancement.</description><identifier>ISSN: 0378-5173</identifier><identifier>EISSN: 1873-3476</identifier><identifier>DOI: 10.1016/S0378-5173(03)00027-9</identifier><identifier>PMID: 12623202</identifier><identifier>CODEN: IJPHDE</identifier><language>eng</language><publisher>Amsterdam: Elsevier B.V</publisher><subject>Biological and medical sciences ; Chemistry, Pharmaceutical ; Compressive Strength ; Compritol ; Fatty Acids - chemistry ; General pharmacology ; Glycerol - analogs & derivatives ; Glycerol - chemistry ; Glyceryl dibehenate ; Lactose ; Lubricant capacity ; Lubrication ; Medical sciences ; Microscopy, Electron, Scanning ; Particle Size ; Pharmaceutical technology. Pharmaceutical industry ; Pharmacology. Drug treatments ; Polyethylene glycol ; Polyethylene Glycols - chemistry ; Powder compression ; Tablets ; Tensile Strength</subject><ispartof>International journal of pharmaceutics, 2003-03, Vol.254 (2), p.263-269</ispartof><rights>2003 Elsevier Science B.V.</rights><rights>2003 INIST-CNRS</rights><rights>Copyright 2003 Elsevier Science B.V.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c391t-a0c15cfe60093fa56440d87baae027dca172bf10e6a558e4c0c9e7788a0868e3</citedby><cites>FETCH-LOGICAL-c391t-a0c15cfe60093fa56440d87baae027dca172bf10e6a558e4c0c9e7788a0868e3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0378517303000279$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3536,27903,27904,65309</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=14661905$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/12623202$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>N’Diaye, A.</creatorcontrib><creatorcontrib>Jannin, V.</creatorcontrib><creatorcontrib>Bérard, V.</creatorcontrib><creatorcontrib>Andrès, C.</creatorcontrib><creatorcontrib>Pourcelot, Y.</creatorcontrib><title>Comparative study of the lubricant performance of Compritol ® HD5 ATO and Compritol ® 888 ATO: effect of polyethylene glycol behenate on lubricant capacity</title><title>International journal of pharmaceutics</title><addtitle>Int J Pharm</addtitle><description>The aim of this paper is to study the lubricant capacity of Compritol HD5 ATO, a glyceryl and polyethylene glycol dibehenate, obtained by atomization. This material is compared to Compritol 888 ATO, constituted only by glyceryl dibehenate. First, this study verifies that Compritol HD5 ATO and Compritol 888 ATO present the same granular characteristics and that their mixes with Lactopress present no structural differences. Secondly, in term of compressibility and cohesiveness, the use of Compritol 888 ATO or Compritol HD5 ATO with Lactopress does not involve any significant modification. Finally, the minor difference of lubricant capacity between Compritol HD5 ATO and Compritol 888 ATO has no consequence in compression practice. The presence of polyethylene glycol behenate does not decrease the glyceryl dibehenate compression functionality. This study concludes that Compritol HD5 ATO could be a very interesting excipient because it associates the glyceryl dibehenate lubricant capacity with the polyethylene glycol behenate-specific capacity in terms of dissolution enhancement.</description><subject>Biological and medical sciences</subject><subject>Chemistry, Pharmaceutical</subject><subject>Compressive Strength</subject><subject>Compritol</subject><subject>Fatty Acids - chemistry</subject><subject>General pharmacology</subject><subject>Glycerol - analogs & derivatives</subject><subject>Glycerol - chemistry</subject><subject>Glyceryl dibehenate</subject><subject>Lactose</subject><subject>Lubricant capacity</subject><subject>Lubrication</subject><subject>Medical sciences</subject><subject>Microscopy, Electron, Scanning</subject><subject>Particle Size</subject><subject>Pharmaceutical technology. Pharmaceutical industry</subject><subject>Pharmacology. Drug treatments</subject><subject>Polyethylene glycol</subject><subject>Polyethylene Glycols - chemistry</subject><subject>Powder compression</subject><subject>Tablets</subject><subject>Tensile Strength</subject><issn>0378-5173</issn><issn>1873-3476</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2003</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkUuO1DAURS0EoouGJYA8AcEgYMeJ7fQEtYpPI7XUA2puvTjPlFE-he20lMWwBRbBynCoEg0jJEsevHPf515CnnL2mjMu33xmQumi5kq8ZOIVY6xURXOPbLhWohCVkvfJ5g9yRh7F-DVDsuTiITnjpSxFycoN-b6dhgMESP4WaUxzt9DJ0bRH2s9t8BbGRA8Y3BQGGC2uxVURfJp6-vMHvXpX08vdDYWx-7egtV4LFxSdQ5tW4WHqF0z7pccR6Zd-sZlscY8jpNx4_GuihQNYn5bH5IGDPuKT039Odh_e77ZXxfXNx0_by-vCioanApjltXUoGWuEg1pWFeu0agEw29JZ4KpsHWcooa41VpbZBpXSGpiWGsU5eXFsewjTtxljMoOPFvseRpzmaJRg-RzFM1gfQRumGAM6kw8eICyGM7PGYn7HYlbPDctvjcU0WffsNGBuB-zuVKccMvD8BEC00LuQzfbxjquk5A2rM_f2yGF249ZjMNF6zMF0PmSXTTf5_6zyC9GorB0</recordid><startdate>20030326</startdate><enddate>20030326</enddate><creator>N’Diaye, A.</creator><creator>Jannin, V.</creator><creator>Bérard, V.</creator><creator>Andrès, C.</creator><creator>Pourcelot, Y.</creator><general>Elsevier B.V</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20030326</creationdate><title>Comparative study of the lubricant performance of Compritol ® HD5 ATO and Compritol ® 888 ATO: effect of polyethylene glycol behenate on lubricant capacity</title><author>N’Diaye, A. ; Jannin, V. ; Bérard, V. ; Andrès, C. ; Pourcelot, Y.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c391t-a0c15cfe60093fa56440d87baae027dca172bf10e6a558e4c0c9e7788a0868e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2003</creationdate><topic>Biological and medical sciences</topic><topic>Chemistry, Pharmaceutical</topic><topic>Compressive Strength</topic><topic>Compritol</topic><topic>Fatty Acids - chemistry</topic><topic>General pharmacology</topic><topic>Glycerol - analogs & derivatives</topic><topic>Glycerol - chemistry</topic><topic>Glyceryl dibehenate</topic><topic>Lactose</topic><topic>Lubricant capacity</topic><topic>Lubrication</topic><topic>Medical sciences</topic><topic>Microscopy, Electron, Scanning</topic><topic>Particle Size</topic><topic>Pharmaceutical technology. Pharmaceutical industry</topic><topic>Pharmacology. Drug treatments</topic><topic>Polyethylene glycol</topic><topic>Polyethylene Glycols - chemistry</topic><topic>Powder compression</topic><topic>Tablets</topic><topic>Tensile Strength</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>N’Diaye, A.</creatorcontrib><creatorcontrib>Jannin, V.</creatorcontrib><creatorcontrib>Bérard, V.</creatorcontrib><creatorcontrib>Andrès, C.</creatorcontrib><creatorcontrib>Pourcelot, Y.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>International journal of pharmaceutics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>N’Diaye, A.</au><au>Jannin, V.</au><au>Bérard, V.</au><au>Andrès, C.</au><au>Pourcelot, Y.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Comparative study of the lubricant performance of Compritol ® HD5 ATO and Compritol ® 888 ATO: effect of polyethylene glycol behenate on lubricant capacity</atitle><jtitle>International journal of pharmaceutics</jtitle><addtitle>Int J Pharm</addtitle><date>2003-03-26</date><risdate>2003</risdate><volume>254</volume><issue>2</issue><spage>263</spage><epage>269</epage><pages>263-269</pages><issn>0378-5173</issn><eissn>1873-3476</eissn><coden>IJPHDE</coden><abstract>The aim of this paper is to study the lubricant capacity of Compritol HD5 ATO, a glyceryl and polyethylene glycol dibehenate, obtained by atomization. This material is compared to Compritol 888 ATO, constituted only by glyceryl dibehenate. First, this study verifies that Compritol HD5 ATO and Compritol 888 ATO present the same granular characteristics and that their mixes with Lactopress present no structural differences. Secondly, in term of compressibility and cohesiveness, the use of Compritol 888 ATO or Compritol HD5 ATO with Lactopress does not involve any significant modification. Finally, the minor difference of lubricant capacity between Compritol HD5 ATO and Compritol 888 ATO has no consequence in compression practice. The presence of polyethylene glycol behenate does not decrease the glyceryl dibehenate compression functionality. This study concludes that Compritol HD5 ATO could be a very interesting excipient because it associates the glyceryl dibehenate lubricant capacity with the polyethylene glycol behenate-specific capacity in terms of dissolution enhancement.</abstract><cop>Amsterdam</cop><pub>Elsevier B.V</pub><pmid>12623202</pmid><doi>10.1016/S0378-5173(03)00027-9</doi><tpages>7</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0378-5173 |
| ispartof | International journal of pharmaceutics, 2003-03, Vol.254 (2), p.263-269 |
| issn | 0378-5173 1873-3476 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_73088871 |
| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Biological and medical sciences Chemistry, Pharmaceutical Compressive Strength Compritol Fatty Acids - chemistry General pharmacology Glycerol - analogs & derivatives Glycerol - chemistry Glyceryl dibehenate Lactose Lubricant capacity Lubrication Medical sciences Microscopy, Electron, Scanning Particle Size Pharmaceutical technology. Pharmaceutical industry Pharmacology. Drug treatments Polyethylene glycol Polyethylene Glycols - chemistry Powder compression Tablets Tensile Strength |
| title | Comparative study of the lubricant performance of Compritol ® HD5 ATO and Compritol ® 888 ATO: effect of polyethylene glycol behenate on lubricant capacity |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-27T04%3A11%3A34IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Comparative%20study%20of%20the%20lubricant%20performance%20of%20Compritol%20%C2%AE%20HD5%20ATO%20and%20Compritol%20%C2%AE%20888%20ATO:%20effect%20of%20polyethylene%20glycol%20behenate%20on%20lubricant%20capacity&rft.jtitle=International%20journal%20of%20pharmaceutics&rft.au=N%E2%80%99Diaye,%20A.&rft.date=2003-03-26&rft.volume=254&rft.issue=2&rft.spage=263&rft.epage=269&rft.pages=263-269&rft.issn=0378-5173&rft.eissn=1873-3476&rft.coden=IJPHDE&rft_id=info:doi/10.1016/S0378-5173(03)00027-9&rft_dat=%3Cproquest_cross%3E73088871%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=73088871&rft_id=info:pmid/12623202&rft_els_id=S0378517303000279&rfr_iscdi=true |