Placental Insufficiency Leads to Development of Hypertension in Growth-Restricted Offspring

ABSTRACT—Low birth weight is a suggested risk factor for the development of hypertension. The purpose of the present study was to determine whether a model of intrauterine growth restriction produced in response to placental insufficiency in the pregnant rat was associated with marked elevations in...

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Veröffentlicht in:	Hypertension (Dallas, Tex. 1979) Tex. 1979), 2003-03, Vol.41 (3), p.457-462
1. Verfasser:	Alexander, Barbara T
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Arterial hypertension. Arterial hypotension Biological and medical sciences Birth Weight Blood and lymphatic vessels Blood Pressure Body Weight Cardiology. Vascular system Disease Susceptibility Experimental diseases Female Fetal Growth Retardation - complications Glomerular Filtration Rate Hypertension - etiology Hypertension - pathology Hypertension - physiopathology Kidney - physiopathology Male Medical sciences Organ Size Placental Insufficiency - complications Pregnancy Rats Rats, Sprague-Dawley
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Zusammenfassung:	ABSTRACT—Low birth weight is a suggested risk factor for the development of hypertension. The purpose of the present study was to determine whether a model of intrauterine growth restriction produced in response to placental insufficiency in the pregnant rat was associated with marked elevations in blood pressure. Reduced uterine perfusion initiated in late gestation resulted in low-birth-weight offspring (5.8±0.1 versus 6.6±0.2 g, P
ISSN:	0194-911X 1524-4563
DOI:	10.1161/01.HYP.0000053448.95913.3D