Interleukin-6 inhibits hepatic growth hormone signaling via upregulation of Cis and Socs-3

Cytokines may cause an acquired growth hormone (GH) resistance in patients with inflammatory diseases. Anabolic effects of GH are mediated through activation of STAT5 transcription factors. We have reported that TNF-alpha suppresses hepatic GH receptor (GHR) gene expression, whereas the cytokine-ind...

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Veröffentlicht in:	American journal of physiology: Gastrointestinal and liver physiology 2003-04, Vol.284 (4), p.G646-G654
Hauptverfasser:	Denson, Lee A, Held, Matthew A, Menon, Ram K, Frank, Stuart J, Parlow, Albert F, Arnold, Dodie L
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antigens, CD - metabolism DNA-Binding Proteins - genetics DNA-Binding Proteins - metabolism Gene Expression - physiology Growth Hormone - pharmacology Immediate-Early Proteins - genetics Interleukin-6 - genetics Interleukin-6 - metabolism Lipopolysaccharides - pharmacology Liver - growth & development Liver - metabolism Male Mice Mice, Inbred C57BL Mice, Mutant Strains Milk Proteins Proteins - genetics Receptors, Tumor Necrosis Factor - metabolism Receptors, Tumor Necrosis Factor, Type I Repressor Proteins RNA, Messenger - analysis Signal Transduction - drug effects Signal Transduction - physiology STAT3 Transcription Factor STAT5 Transcription Factor Suppressor of Cytokine Signaling 3 Protein Suppressor of Cytokine Signaling Proteins Trans-Activators - genetics Trans-Activators - metabolism Transcription Factors Tumor Necrosis Factor-alpha - metabolism Up-Regulation - physiology
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