Chiral separation by high performance liquid chromatography. I. Review on indirect separation of enantiomers as diastereomeric derivatives using ultraviolet, fluorescence and electrochemical detection
The increased attention on the therapeutic implications of stereoisomerism has provided an impetus for the development of analytical methods for enantiomeric separation. The indirect method of separation of enantiomers as diastereomers using high performance liquid chromatography (HPLC) has emerged...
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| Veröffentlicht in: | Biomedical chromatography 1992-07, Vol.6 (4), p.163-167 |
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| container_title | Biomedical chromatography |
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| creator | Srinivas, Nuggehally R. Igwemezie, Linus N. |
| description | The increased attention on the therapeutic implications of stereoisomerism has provided an impetus for the development of analytical methods for enantiomeric separation. The indirect method of separation of enantiomers as diastereomers using high performance liquid chromatography (HPLC) has emerged as an efficient and versatile approach. This is due mainly to the availability of numerous chiral derivatization reagents (CDRs). This article reviews CDRs useful for the development of an indirect HPLC method using ultraviolet, fluoresence and electrochemical detection. In addition, factors crucial for the development of the indirect method are discussed. |
| doi_str_mv | 10.1002/bmc.1130060402 |
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| ispartof | Biomedical chromatography, 1992-07, Vol.6 (4), p.163-167 |
| issn | 0269-3879 1099-0801 |
| language | eng |
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| source | MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | Chromatography, High Pressure Liquid - methods Electrochemistry Spectrometry, Fluorescence Spectrophotometry, Ultraviolet Stereoisomerism |
| title | Chiral separation by high performance liquid chromatography. I. Review on indirect separation of enantiomers as diastereomeric derivatives using ultraviolet, fluorescence and electrochemical detection |
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