Voxel-based morphometry in hypocretin-deficient narcolepsy

Recent studies suggest that narcolepsy is caused by degeneration of hypocretin (orexin) producing neurons. To find evidence for this hypothesis, we aimed to detect structural changes in the hypothalamus and/or hypocretin projection areas of patients with narcolepsy. We used voxel-based morphometry (...

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Veröffentlicht in:	Sleep (New York, N.Y.) N.Y.), 2003-02, Vol.26 (1), p.44-46
Hauptverfasser:	OVEREEM, Sebastiaan, STEENS, Stefan C. A, GOOD, Catriona D, FERRARI, Michel D, MIGNOT, Emmanuel, FRACKOWIAK, Richard S. J, VAN BUCHEM, Mark A, LAMMERS, Gert Jan
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Biological and medical sciences Brain - anatomy & histology Carrier Proteins Disorders of higher nervous function. Focal brain diseases. Central vestibular syndrome and deafness. Brain stem syndromes Female Humans Hypothalamus - metabolism Intracellular Signaling Peptides and Proteins Magnetic Resonance Imaging Male Medical sciences Middle Aged Narcolepsy - metabolism Nervous system (semeiology, syndromes) Neurology Neurons - metabolism Neuropeptides - deficiency Orexins
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