Structural Basis for the Antibiotic Activity of Ketolides and Azalides

The azalide azithromycin and the ketolide ABT-773, which were derived by chemical modifications of erythromycin, exhibit elevated activity against a number of penicillin- and macrolide-resistant pathogenic bacteria. Analysis of the crystal structures of the large ribosomal subunit from Deinococcus r...

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Veröffentlicht in:	Structure (London) 2003-03, Vol.11 (3), p.329-338
Hauptverfasser:	Schlünzen, Frank, Harms, Jörg M, Franceschi, Francois, Hansen, Harly A.S, Bartels, Heike, Zarivach, Raz, Yonath, Ada
Format:	Artikel
Sprache:	eng
Schlagworte:	Anti-Bacterial Agents - chemistry Anti-Bacterial Agents - metabolism antibiotics azalides azithromycin Azithromycin - chemistry Azithromycin - metabolism Erythromycin - analogs & derivatives Erythromycin - chemistry Erythromycin - metabolism Ketolides peptidyl transferase center ribosome Ribosomes - metabolism RNA, Ribosomal Structure-Activity Relationship
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