Activation of calcium-dependent calmodulin by calcium(II)3(3,5-diisopropylsalicylate)6(H2O)6 decreases thrombin receptor activating peptide-induced P-selectin expression

We examined the influence of 3,5-diisopropylsalicylic acid (3,5-DIPS) and calcium(II)3(3,5-diisopropylsalicylate)6 (H2O)6 [Ca(II)3(3,5-DIPS)6], a new activator of calcium-dependent calmodulin-triggered nitric oxide synthase, on thrombin-induced platelet P-selectin expression. Citrated whole blood sa...

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Veröffentlicht in:	Blood coagulation & fibrinolysis 2003-02, Vol.14 (2), p.131-138
Hauptverfasser:	Homoncik, Monika, Jilma, Bernd, Donham, Douglas C, Frossard, Martin, Keuzer, Claudia, Sorenson, John RJ
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine Diphosphate - pharmacology Adult Biological and medical sciences Blood coagulation. Blood cells Blood Platelets - drug effects Blood Platelets - metabolism Calcium - chemistry Calcium - pharmacology Calmodulin - drug effects Calmodulin - metabolism Cross-Sectional Studies Dose-Response Relationship, Drug Enzyme Inhibitors - pharmacology Female Flow Cytometry Fundamental and applied biological sciences. Psychology Humans In Vitro Techniques Male Molecular and cellular biology Molsidomine - analogs & derivatives Molsidomine - pharmacology Nitric Oxide Synthase - antagonists & inhibitors omega-N-Methylarginine - pharmacology P-Selectin - blood P-Selectin - drug effects P-Selectin - metabolism Peptide Fragments - pharmacology Platelet Platelet Aggregation Inhibitors - pharmacology Salicylates - chemistry Salicylates - pharmacology
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