Antitumor Activity of Novel Deoxoartemisinin Monomers, Dimers, and Trimer

The first primary amines 9 and bromoalkyl analogues 7 of deoxoartemisinin with nonacetal functionality at C-12 are prepared as versatile intermediates for the synthesis of various derivatives. Eight C-12 nonacetal type dimers and one trimer of deoxoartemisinin were prepared using novel chemistry. Di...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Journal of medicinal chemistry 2003-03, Vol.46 (6), p.987-994
Hauptverfasser:	Jung, Mankil, Lee, Sangmin, Ham, Jungyeob, Lee, Kyunghoon, Kim, Hanjo, Kim, Soo Kie
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antineoplastic agents Antineoplastic Agents - chemical synthesis Antineoplastic Agents - chemistry Antineoplastic Agents - pharmacology Artemisinins - chemical synthesis Artemisinins - chemistry Artemisinins - pharmacology Biological and medical sciences Drug Screening Assays, Antitumor General aspects Humans Medical sciences Mice Pharmacology. Drug treatments Polymers Sesquiterpenes - chemical synthesis Sesquiterpenes - chemistry Sesquiterpenes - pharmacology Structure-Activity Relationship Tumor Cells, Cultured
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!