CD8 lymphocytosis and pseudotumoral splenomegaly in HIV infection

Three patients infected with human immunodeficiency virus (HIV) presented with pseudotumoral splenomegaly, CD8 lymphocytosis (3·5-5·1 × 10 9/l), and hypergammaglobulinaemia. Spleen and bone marrow showed diffuse CD8 lymphocyte and plasma-cell infiltration. Amplification of the T-cell-receptor gamma...

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Veröffentlicht in:The Lancet (British edition) 1992-07, Vol.340 (8813), p.207-208
Hauptverfasser: Oksenhendler, E., Seligmann, M., Clauvel, J-P., Gorochov, G., d'Agay, M.F., Autran, Brigitte
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container_end_page 208
container_issue 8813
container_start_page 207
container_title The Lancet (British edition)
container_volume 340
creator Oksenhendler, E.
Seligmann, M.
Clauvel, J-P.
Gorochov, G.
d'Agay, M.F.
Autran, Brigitte
description Three patients infected with human immunodeficiency virus (HIV) presented with pseudotumoral splenomegaly, CD8 lymphocytosis (3·5-5·1 × 10 9/l), and hypergammaglobulinaemia. Spleen and bone marrow showed diffuse CD8 lymphocyte and plasma-cell infiltration. Amplification of the T-cell-receptor gamma chain gene did not reveal any clonal T-cell population. Phenotypic analysis showed a predominance of CD8/CD57 suppressor T cells with expression of activation markers (DR and CD38). No cytotoxic T lymphocytes specific for H IV could be detected. The three patients shared the HLA haplotype A1, B8, DR3. The association with this haplotype suggests a genetically determined host immune response to HIV.
doi_str_mv 10.1016/0140-6736(92)90471-E
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subjects Acquired immune deficiency syndrome
Acquired Immunodeficiency Syndrome - complications
Acquired Immunodeficiency Syndrome - immunology
Adult
AIDS
AIDS/HIV
Biological and medical sciences
Bone marrow
CD8 Antigens - immunology
CD8 Antigens - isolation & purification
Female
Genetics
Homosexuality
Humans
Immune response
Immunity (Disease)
Immunity, Cellular
Immunodeficiencies
Immunodeficiencies. Immunoglobulinopathies
Immunopathology
Lymphocytes
Lymphocytosis - complications
Lymphocytosis - immunology
Male
Medical research
Medical sciences
Opportunistic Infections - complications
Opportunistic Infections - immunology
Phenotype
Splenomegaly - complications
Viruses
title CD8 lymphocytosis and pseudotumoral splenomegaly in HIV infection
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