Inhibition of actin polymerization by peroxynitrite modulates neutrophil functional responses

Peroxynitrite, a potent oxidant generated in inflammatory tissues, can nitrate tyrosine residues on a variety of proteins. Based on previous studies suggesting that actin might be a potential target for peroxynitrite‐mediated nitration in neutrophils, we investigated the effects of peroxynitrite on...

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Veröffentlicht in:	Journal of leukocyte biology 2003-03, Vol.73 (3), p.344-355
Hauptverfasser:	Clements, Mark K., Siemsen, Daniel W., Swain, Steve D., Hanson, Angela J., Nelson‐Overton, Laura K., Rohn, Troy T., Quinn, Mark T.
Format:	Artikel
Sprache:	eng
Schlagworte:	Actins - antagonists & inhibitors Actins - metabolism Chemotaxis - drug effects cytoskeleton Dimerization Dose-Response Relationship, Drug Humans Molsidomine - analogs & derivatives Molsidomine - pharmacology NADPH oxidase Neutrophil Activation Neutrophils - drug effects Neutrophils - physiology Neutrophils - ultrastructure Nitric Oxide Donors nitrotyrosine Peroxynitrous Acid - pharmacology Phagocytosis - drug effects polymorphonuclear leukocytes Reactive Oxygen Species - metabolism Respiratory Burst - drug effects Tyrosine - analogs & derivatives Tyrosine - analysis
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