Specificity of human immunodeficiency virus-1 reverse transcriptase-associated ribonuclease H in removal of the minus-strand primer, tRNA(Lys3)

We have examined the specificity of human immunodeficiency virus-1 (HIV-1) reverse transcriptase-associated RNase H in removing the tRNA(Lys3) (-)-strand primer in vitro using a model substrate. This substrate represents an intermediate in the reverse transcription process where the tRNA(Lys3) prime...

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Veröffentlicht in:	The Journal of biological chemistry 1992-07, Vol.267 (21), p.15071-15079
Hauptverfasser:	Smith, J S, Roth, M J
Format:	Artikel
Sprache:	eng
Schlagworte:	AIDS/HIV Base Sequence Chromatography, Thin Layer DNA, Viral - biosynthesis HIV Long Terminal Repeat HIV Reverse Transcriptase HIV-1 - enzymology HIV-1 - metabolism Molecular Sequence Data Oligonucleotides Plasmids Ribonuclease H - metabolism RNA, Transfer, Lys - metabolism RNA-Directed DNA Polymerase - metabolism Substrate Specificity Transcription, Genetic
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