A Broad-Spectrum Caspase Inhibitor Attenuates Allergic Airway Inflammation in Murine Asthma Model

Asthma is characterized by acute and chronic airway inflammation, and the severity of the airway hyperreactivity correlates with the degree of inflammation. Many of the features of lung inflammation observed in human asthma are reproduced in OVA-sensitized/challenged mice. T lymphocytes, particularl...

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Veröffentlicht in:	The Journal of immunology (1950) 2003-03, Vol.170 (6), p.3386-3391
Hauptverfasser:	Iwata, Akiko, Nishio, Kazumi, Winn, Robert K, Chi, Emil Y, Henderson, William R., Jr, Harlan, John M
Format:	Artikel
Sprache:	eng
Schlagworte:	Aerosols Allergens - administration & dosage Allergens - immunology Amino Acid Chloromethyl Ketones - pharmacology Amino Acid Chloromethyl Ketones - therapeutic use Animals Asthma - enzymology Asthma - immunology Asthma - pathology Bronchial Hyperreactivity - enzymology Bronchial Hyperreactivity - immunology Bronchial Hyperreactivity - pathology Bronchoalveolar Lavage Fluid - chemistry Bronchoalveolar Lavage Fluid - cytology Caspase Inhibitors Cell Movement - drug effects Cell Movement - immunology Cysteine Proteinase Inhibitors - pharmacology Disease Models, Animal Inflammation - enzymology Inflammation - immunology Inflammation - prevention & control Interleukin-4 - metabolism Interleukin-5 - metabolism Intubation, Intratracheal Leukocytes - pathology Lung - enzymology Lung - immunology Lung - pathology Lymphocyte Activation - drug effects Methacholine Chloride - administration & dosage Mice Mice, Inbred BALB C Ovalbumin - administration & dosage Ovalbumin - immunology T-Lymphocytes - drug effects T-Lymphocytes - immunology
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