Kaposi's sarcoma associated herpesvirus G protein-coupled receptor immortalizes human endothelial cells by activation of the VEGF receptor-2/ KDR

The G protein-coupled receptor oncogene ( vGPCR) of the Kaposi's sarcoma (KS) associated herpesvirus (KSHV), an oncovirus implicated in angioproliferative neoplasms, induces angiogenesis by VEGF secretion. Accordingly, we found that expression of vGPCR in human umbilical vein endothelial cells...

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Veröffentlicht in:	Cancer cell 2003-02, Vol.3 (2), p.131-143
Hauptverfasser:	Bais, Carlos, Van Geelen, Albert, Eroles, Pilar, Mutlu, Agata, Chiozzini, Chiara, Dias, Sergio, Silverstein, Roy L, Rafii, Shahin, Mesri, Enrique A
Format:	Artikel
Sprache:	eng
Schlagworte:	Apoptosis Cell Transformation, Neoplastic Cells, Cultured Endothelial Growth Factors - metabolism Endothelium, Vascular - metabolism Endothelium, Vascular - pathology Endothelium, Vascular - virology Herpesvirus 8, Human - pathogenicity Humans Intercellular Signaling Peptides and Proteins - metabolism Lymphokines - metabolism Phosphatidylinositol 3-Kinases - metabolism Phosphorylation Protein-Serine-Threonine Kinases Proto-Oncogene Proteins - metabolism Proto-Oncogene Proteins c-akt Receptors, Chemokine - physiology Retroviridae - genetics Sarcoma, Kaposi - metabolism Sarcoma, Kaposi - pathology Sarcoma, Kaposi - virology Signal Transduction Telomerase - metabolism Telomere - metabolism Umbilical Veins Vascular Endothelial Growth Factor A Vascular Endothelial Growth Factor Receptor-2 - metabolism Vascular Endothelial Growth Factors Viral Proteins - physiology
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