Interleukin-2 (IL-2) induces tyrosine kinase-dependent translocation of active raf-1 from the IL-2 receptor into the cytosol

Stimulation of the interleukin-2 (IL-2) receptor results in phosphorylation and activation of cytosolic Raf-1 serine/threonine kinase. Herein, we report that enzymatically active Raf-1 is physically associated with the IL-2 receptor beta chain (p75) in T-cell blasts. Following stimulation with IL-2,...

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Veröffentlicht in:	The Journal of biological chemistry 1992-08, Vol.267 (22), p.15281-15284
Hauptverfasser:	MASLINSKI, W, REMILLARD, B, TSUDO, M, STROM, T. B
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological and medical sciences Blotting, Western Cell Membrane - metabolism Cell receptors Cell structures and functions Cells, Cultured Cytosol - metabolism Fundamental and applied biological sciences. Psychology Humans Interleukin-2 - metabolism Interleukin-2 - pharmacology Methionine - blood Miscellaneous Models, Biological Molecular and cellular biology Monocytes - immunology Monocytes - metabolism Protein Kinases - blood Protein-Tyrosine Kinases - blood Proto-Oncogene Proteins - blood Proto-Oncogene Proteins c-raf Receptors, Interleukin-2 - metabolism Recombinant Proteins - metabolism Recombinant Proteins - pharmacology
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