A Randomized Trial of Aspirin to Prevent Colorectal Adenomas in Patients with Previous Colorectal Cancer
In this randomized, double-blind trial, daily ingestion of aspirin reduced the incidence of colorectal polyps among patients with previous colorectal cancer. Of 258 patients in the placebo group who underwent colonoscopy, polyps were found in 70, whereas 43 of 259 patients in the aspirin group were...
Gespeichert in:
| Veröffentlicht in: | The New England journal of medicine 2003-03, Vol.348 (10), p.883-890 |
|---|---|
| Hauptverfasser: | , , , , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 890 |
|---|---|
| container_issue | 10 |
| container_start_page | 883 |
| container_title | The New England journal of medicine |
| container_volume | 348 |
| creator | Sandler, Robert S Halabi, Susan Baron, John A Budinger, Susan Paskett, Electra Keresztes, Roger Petrelli, Nicholas Pipas, J. Marc Karp, Daniel D Loprinzi, Charles L Steinbach, Gideon Schilsky, Richard |
| description | In this randomized, double-blind trial, daily ingestion of aspirin reduced the incidence of colorectal polyps among patients with previous colorectal cancer. Of 258 patients in the placebo group who underwent colonoscopy, polyps were found in 70, whereas 43 of 259 patients in the aspirin group were found to have polyps.
There is considerable evidence that aspirin and other nonsteroidal antiinflammatory drugs (NSAIDs) may decrease the risk of colorectal neoplasia.
1
–
3
Experiments in rodents have demonstrated that indomethacin decreases the incidence of carcinogen-induced colonic tumors,
4
and both retrospective and prospective studies found that NSAIDs protect against colorectal cancer in humans.
5
–
9
Moreover, randomized trials demonstrated a decrease in the number and size of adenomas in patients with familial adenomatous polyposis who received celecoxib or sulindac.
10
,
11
It is difficult to show that NSAIDs prevent colorectal cancer because of the long latency period before cancer develops. Because most colorectal cancers arise from . . . |
| doi_str_mv | 10.1056/NEJMoa021633 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_73076235</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>73076235</sourcerecordid><originalsourceid>FETCH-LOGICAL-c516t-ac8a3f2a82810d4d8594813a20db9c7bef626af28edc6ecd46a0debf586ba2e43</originalsourceid><addsrcrecordid>eNpt0DtPwzAQB3ALgaA8NmbkAZgI-BUnHauKp3gJwRxd7IswSuJipyD49BhaCQZuucE_3fn-hOxydsxZrk9uT69uPDDBtZQrZMRzKTOlmF4lI8ZEmaliLDfIZowvLBVX43WywYUWnEsxIs8T-gC99Z37REsfg4OW-oZO4swF19PB0_uAb9gPdOpbH9AMCUws9r6DSJO4h8Gl50jf3fD8g52fx796Cr3BsE3WGmgj7iz7Fnk6O32cXmTXd-eX08l1ZnKuhwxMCbIRUIqSM6tsmY9VySUIZuuxKWpstNDQiBKt0Wis0sAs1k1e6hoEKrlFDhdzZ8G_zjEOVeeiwbaFHtPHqkKyQguZJ3i0gCb4GAM21Sy4DsJHxVn1nWz1N9nE95Zz53WH9hcvo0zgYAkgGmibkM528depvEjFk9tfuK6LVY8v3f_7vgDTEI0d</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>73076235</pqid></control><display><type>article</type><title>A Randomized Trial of Aspirin to Prevent Colorectal Adenomas in Patients with Previous Colorectal Cancer</title><source>MEDLINE</source><source>EZB-FREE-00999 freely available EZB journals</source><source>ProQuest Central UK/Ireland</source><source>New England Journal of Medicine</source><creator>Sandler, Robert S ; Halabi, Susan ; Baron, John A ; Budinger, Susan ; Paskett, Electra ; Keresztes, Roger ; Petrelli, Nicholas ; Pipas, J. Marc ; Karp, Daniel D ; Loprinzi, Charles L ; Steinbach, Gideon ; Schilsky, Richard</creator><creatorcontrib>Sandler, Robert S ; Halabi, Susan ; Baron, John A ; Budinger, Susan ; Paskett, Electra ; Keresztes, Roger ; Petrelli, Nicholas ; Pipas, J. Marc ; Karp, Daniel D ; Loprinzi, Charles L ; Steinbach, Gideon ; Schilsky, Richard</creatorcontrib><description>In this randomized, double-blind trial, daily ingestion of aspirin reduced the incidence of colorectal polyps among patients with previous colorectal cancer. Of 258 patients in the placebo group who underwent colonoscopy, polyps were found in 70, whereas 43 of 259 patients in the aspirin group were found to have polyps.
There is considerable evidence that aspirin and other nonsteroidal antiinflammatory drugs (NSAIDs) may decrease the risk of colorectal neoplasia.
1
–
3
Experiments in rodents have demonstrated that indomethacin decreases the incidence of carcinogen-induced colonic tumors,
4
and both retrospective and prospective studies found that NSAIDs protect against colorectal cancer in humans.
5
–
9
Moreover, randomized trials demonstrated a decrease in the number and size of adenomas in patients with familial adenomatous polyposis who received celecoxib or sulindac.
10
,
11
It is difficult to show that NSAIDs prevent colorectal cancer because of the long latency period before cancer develops. Because most colorectal cancers arise from . . .</description><identifier>ISSN: 0028-4793</identifier><identifier>EISSN: 1533-4406</identifier><identifier>DOI: 10.1056/NEJMoa021633</identifier><identifier>PMID: 12621132</identifier><identifier>CODEN: NEJMAG</identifier><language>eng</language><publisher>Boston, MA: Massachusetts Medical Society</publisher><subject>Adenoma - mortality ; Adenoma - prevention & control ; Adult ; Aged ; Anti-Inflammatory Agents, Non-Steroidal - therapeutic use ; Aspirin - therapeutic use ; Biological and medical sciences ; Colonic Polyps - diagnosis ; Colonic Polyps - prevention & control ; Colonoscopy ; Colorectal Neoplasms - mortality ; Colorectal Neoplasms - prevention & control ; Digestive system ; Disease-Free Survival ; Double-Blind Method ; Female ; Gastroenterology. Liver. Pancreas. Abdomen ; Humans ; Male ; Medical sciences ; Middle Aged ; Multivariate Analysis ; Pharmacology. Drug treatments ; Risk ; Secondary Prevention ; Stomach. Duodenum. Small intestine. Colon. Rectum. Anus ; Tumors</subject><ispartof>The New England journal of medicine, 2003-03, Vol.348 (10), p.883-890</ispartof><rights>Copyright © 2003 Massachusetts Medical Society. All rights reserved.</rights><rights>2003 INIST-CNRS</rights><rights>Copyright 2003 Massachusetts Medical Society</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c516t-ac8a3f2a82810d4d8594813a20db9c7bef626af28edc6ecd46a0debf586ba2e43</citedby><cites>FETCH-LOGICAL-c516t-ac8a3f2a82810d4d8594813a20db9c7bef626af28edc6ecd46a0debf586ba2e43</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.nejm.org/doi/pdf/10.1056/NEJMoa021633$$EPDF$$P50$$Gmms$$H</linktopdf><linktohtml>$$Uhttps://www.nejm.org/doi/full/10.1056/NEJMoa021633$$EHTML$$P50$$Gmms$$H</linktohtml><link.rule.ids>314,780,784,2758,2759,26102,27923,27924,52381,54063,64386</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=14577771$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/12621132$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Sandler, Robert S</creatorcontrib><creatorcontrib>Halabi, Susan</creatorcontrib><creatorcontrib>Baron, John A</creatorcontrib><creatorcontrib>Budinger, Susan</creatorcontrib><creatorcontrib>Paskett, Electra</creatorcontrib><creatorcontrib>Keresztes, Roger</creatorcontrib><creatorcontrib>Petrelli, Nicholas</creatorcontrib><creatorcontrib>Pipas, J. Marc</creatorcontrib><creatorcontrib>Karp, Daniel D</creatorcontrib><creatorcontrib>Loprinzi, Charles L</creatorcontrib><creatorcontrib>Steinbach, Gideon</creatorcontrib><creatorcontrib>Schilsky, Richard</creatorcontrib><title>A Randomized Trial of Aspirin to Prevent Colorectal Adenomas in Patients with Previous Colorectal Cancer</title><title>The New England journal of medicine</title><addtitle>N Engl J Med</addtitle><description>In this randomized, double-blind trial, daily ingestion of aspirin reduced the incidence of colorectal polyps among patients with previous colorectal cancer. Of 258 patients in the placebo group who underwent colonoscopy, polyps were found in 70, whereas 43 of 259 patients in the aspirin group were found to have polyps.
There is considerable evidence that aspirin and other nonsteroidal antiinflammatory drugs (NSAIDs) may decrease the risk of colorectal neoplasia.
1
–
3
Experiments in rodents have demonstrated that indomethacin decreases the incidence of carcinogen-induced colonic tumors,
4
and both retrospective and prospective studies found that NSAIDs protect against colorectal cancer in humans.
5
–
9
Moreover, randomized trials demonstrated a decrease in the number and size of adenomas in patients with familial adenomatous polyposis who received celecoxib or sulindac.
10
,
11
It is difficult to show that NSAIDs prevent colorectal cancer because of the long latency period before cancer develops. Because most colorectal cancers arise from . . .</description><subject>Adenoma - mortality</subject><subject>Adenoma - prevention & control</subject><subject>Adult</subject><subject>Aged</subject><subject>Anti-Inflammatory Agents, Non-Steroidal - therapeutic use</subject><subject>Aspirin - therapeutic use</subject><subject>Biological and medical sciences</subject><subject>Colonic Polyps - diagnosis</subject><subject>Colonic Polyps - prevention & control</subject><subject>Colonoscopy</subject><subject>Colorectal Neoplasms - mortality</subject><subject>Colorectal Neoplasms - prevention & control</subject><subject>Digestive system</subject><subject>Disease-Free Survival</subject><subject>Double-Blind Method</subject><subject>Female</subject><subject>Gastroenterology. Liver. Pancreas. Abdomen</subject><subject>Humans</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Multivariate Analysis</subject><subject>Pharmacology. Drug treatments</subject><subject>Risk</subject><subject>Secondary Prevention</subject><subject>Stomach. Duodenum. Small intestine. Colon. Rectum. Anus</subject><subject>Tumors</subject><issn>0028-4793</issn><issn>1533-4406</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2003</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpt0DtPwzAQB3ALgaA8NmbkAZgI-BUnHauKp3gJwRxd7IswSuJipyD49BhaCQZuucE_3fn-hOxydsxZrk9uT69uPDDBtZQrZMRzKTOlmF4lI8ZEmaliLDfIZowvLBVX43WywYUWnEsxIs8T-gC99Z37REsfg4OW-oZO4swF19PB0_uAb9gPdOpbH9AMCUws9r6DSJO4h8Gl50jf3fD8g52fx796Cr3BsE3WGmgj7iz7Fnk6O32cXmTXd-eX08l1ZnKuhwxMCbIRUIqSM6tsmY9VySUIZuuxKWpstNDQiBKt0Wis0sAs1k1e6hoEKrlFDhdzZ8G_zjEOVeeiwbaFHtPHqkKyQguZJ3i0gCb4GAM21Sy4DsJHxVn1nWz1N9nE95Zz53WH9hcvo0zgYAkgGmibkM528depvEjFk9tfuK6LVY8v3f_7vgDTEI0d</recordid><startdate>20030306</startdate><enddate>20030306</enddate><creator>Sandler, Robert S</creator><creator>Halabi, Susan</creator><creator>Baron, John A</creator><creator>Budinger, Susan</creator><creator>Paskett, Electra</creator><creator>Keresztes, Roger</creator><creator>Petrelli, Nicholas</creator><creator>Pipas, J. Marc</creator><creator>Karp, Daniel D</creator><creator>Loprinzi, Charles L</creator><creator>Steinbach, Gideon</creator><creator>Schilsky, Richard</creator><general>Massachusetts Medical Society</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20030306</creationdate><title>A Randomized Trial of Aspirin to Prevent Colorectal Adenomas in Patients with Previous Colorectal Cancer</title><author>Sandler, Robert S ; Halabi, Susan ; Baron, John A ; Budinger, Susan ; Paskett, Electra ; Keresztes, Roger ; Petrelli, Nicholas ; Pipas, J. Marc ; Karp, Daniel D ; Loprinzi, Charles L ; Steinbach, Gideon ; Schilsky, Richard</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c516t-ac8a3f2a82810d4d8594813a20db9c7bef626af28edc6ecd46a0debf586ba2e43</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2003</creationdate><topic>Adenoma - mortality</topic><topic>Adenoma - prevention & control</topic><topic>Adult</topic><topic>Aged</topic><topic>Anti-Inflammatory Agents, Non-Steroidal - therapeutic use</topic><topic>Aspirin - therapeutic use</topic><topic>Biological and medical sciences</topic><topic>Colonic Polyps - diagnosis</topic><topic>Colonic Polyps - prevention & control</topic><topic>Colonoscopy</topic><topic>Colorectal Neoplasms - mortality</topic><topic>Colorectal Neoplasms - prevention & control</topic><topic>Digestive system</topic><topic>Disease-Free Survival</topic><topic>Double-Blind Method</topic><topic>Female</topic><topic>Gastroenterology. Liver. Pancreas. Abdomen</topic><topic>Humans</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Multivariate Analysis</topic><topic>Pharmacology. Drug treatments</topic><topic>Risk</topic><topic>Secondary Prevention</topic><topic>Stomach. Duodenum. Small intestine. Colon. Rectum. Anus</topic><topic>Tumors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Sandler, Robert S</creatorcontrib><creatorcontrib>Halabi, Susan</creatorcontrib><creatorcontrib>Baron, John A</creatorcontrib><creatorcontrib>Budinger, Susan</creatorcontrib><creatorcontrib>Paskett, Electra</creatorcontrib><creatorcontrib>Keresztes, Roger</creatorcontrib><creatorcontrib>Petrelli, Nicholas</creatorcontrib><creatorcontrib>Pipas, J. Marc</creatorcontrib><creatorcontrib>Karp, Daniel D</creatorcontrib><creatorcontrib>Loprinzi, Charles L</creatorcontrib><creatorcontrib>Steinbach, Gideon</creatorcontrib><creatorcontrib>Schilsky, Richard</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>The New England journal of medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Sandler, Robert S</au><au>Halabi, Susan</au><au>Baron, John A</au><au>Budinger, Susan</au><au>Paskett, Electra</au><au>Keresztes, Roger</au><au>Petrelli, Nicholas</au><au>Pipas, J. Marc</au><au>Karp, Daniel D</au><au>Loprinzi, Charles L</au><au>Steinbach, Gideon</au><au>Schilsky, Richard</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A Randomized Trial of Aspirin to Prevent Colorectal Adenomas in Patients with Previous Colorectal Cancer</atitle><jtitle>The New England journal of medicine</jtitle><addtitle>N Engl J Med</addtitle><date>2003-03-06</date><risdate>2003</risdate><volume>348</volume><issue>10</issue><spage>883</spage><epage>890</epage><pages>883-890</pages><issn>0028-4793</issn><eissn>1533-4406</eissn><coden>NEJMAG</coden><abstract>In this randomized, double-blind trial, daily ingestion of aspirin reduced the incidence of colorectal polyps among patients with previous colorectal cancer. Of 258 patients in the placebo group who underwent colonoscopy, polyps were found in 70, whereas 43 of 259 patients in the aspirin group were found to have polyps.
There is considerable evidence that aspirin and other nonsteroidal antiinflammatory drugs (NSAIDs) may decrease the risk of colorectal neoplasia.
1
–
3
Experiments in rodents have demonstrated that indomethacin decreases the incidence of carcinogen-induced colonic tumors,
4
and both retrospective and prospective studies found that NSAIDs protect against colorectal cancer in humans.
5
–
9
Moreover, randomized trials demonstrated a decrease in the number and size of adenomas in patients with familial adenomatous polyposis who received celecoxib or sulindac.
10
,
11
It is difficult to show that NSAIDs prevent colorectal cancer because of the long latency period before cancer develops. Because most colorectal cancers arise from . . .</abstract><cop>Boston, MA</cop><pub>Massachusetts Medical Society</pub><pmid>12621132</pmid><doi>10.1056/NEJMoa021633</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0028-4793 |
| ispartof | The New England journal of medicine, 2003-03, Vol.348 (10), p.883-890 |
| issn | 0028-4793 1533-4406 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_73076235 |
| source | MEDLINE; EZB-FREE-00999 freely available EZB journals; ProQuest Central UK/Ireland; New England Journal of Medicine |
| subjects | Adenoma - mortality Adenoma - prevention & control Adult Aged Anti-Inflammatory Agents, Non-Steroidal - therapeutic use Aspirin - therapeutic use Biological and medical sciences Colonic Polyps - diagnosis Colonic Polyps - prevention & control Colonoscopy Colorectal Neoplasms - mortality Colorectal Neoplasms - prevention & control Digestive system Disease-Free Survival Double-Blind Method Female Gastroenterology. Liver. Pancreas. Abdomen Humans Male Medical sciences Middle Aged Multivariate Analysis Pharmacology. Drug treatments Risk Secondary Prevention Stomach. Duodenum. Small intestine. Colon. Rectum. Anus Tumors |
| title | A Randomized Trial of Aspirin to Prevent Colorectal Adenomas in Patients with Previous Colorectal Cancer |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-08T18%3A43%3A50IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=A%20Randomized%20Trial%20of%20Aspirin%20to%20Prevent%20Colorectal%20Adenomas%20in%20Patients%20with%20Previous%20Colorectal%20Cancer&rft.jtitle=The%20New%20England%20journal%20of%20medicine&rft.au=Sandler,%20Robert%20S&rft.date=2003-03-06&rft.volume=348&rft.issue=10&rft.spage=883&rft.epage=890&rft.pages=883-890&rft.issn=0028-4793&rft.eissn=1533-4406&rft.coden=NEJMAG&rft_id=info:doi/10.1056/NEJMoa021633&rft_dat=%3Cproquest_cross%3E73076235%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=73076235&rft_id=info:pmid/12621132&rfr_iscdi=true |